[IgA-mediated auto-immune haemolytic anaemia revealing a hepatitis C virus infection]
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[IgA-mediated auto-immune haemolytic anaemia revealing a hepatitis C virus infection]. / Grimaldi, D; Limal, N; Noizat-Pirenne, F; Janvier, D; Godeau, B; Michel, Melanie.
in: REV MED INTERNE, Jahrgang 29, Nr. 2, 2, 2008, S. 135-138.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - [IgA-mediated auto-immune haemolytic anaemia revealing a hepatitis C virus infection]
AU - Grimaldi, D
AU - Limal, N
AU - Noizat-Pirenne, F
AU - Janvier, D
AU - Godeau, B
AU - Michel, Melanie
PY - 2008
Y1 - 2008
N2 - INTRODUCTION: Confirmation of autoimmune hemolytic anaemia usually relies on the detection of erythrocyte membrane-bound autoantibodies using a direct antiglobulin test. In the rare case of IgA autoantibodies-mediated autoimmune hemolytic anemia, the direct antiglobulin test can be negative, because routinely used polyspecific direct antiglobulin test reagents contain only anti-IgG and anticomplement antibodies. EXEGESIS: We report the case of a 41-year-old woman presenting a severe autoimmune hemolytic anaemia caused by the presence of warm autoantibodies of IgA type that revealed a chronic hepatitis C virus infection. CONCLUSION: A negative direct antiglobulin test does not completely rule out the diagnosis of autoimmune hemolytic anaemia especially in the rare case of IgA mediated immune hemolysis. The diagnosis strategy of autoimmune hemolytic anaemia associated with negative direct antiglobulin test and the potential links between autoimmune hemolytic anaemia and HCV are discussed.
AB - INTRODUCTION: Confirmation of autoimmune hemolytic anaemia usually relies on the detection of erythrocyte membrane-bound autoantibodies using a direct antiglobulin test. In the rare case of IgA autoantibodies-mediated autoimmune hemolytic anemia, the direct antiglobulin test can be negative, because routinely used polyspecific direct antiglobulin test reagents contain only anti-IgG and anticomplement antibodies. EXEGESIS: We report the case of a 41-year-old woman presenting a severe autoimmune hemolytic anaemia caused by the presence of warm autoantibodies of IgA type that revealed a chronic hepatitis C virus infection. CONCLUSION: A negative direct antiglobulin test does not completely rule out the diagnosis of autoimmune hemolytic anaemia especially in the rare case of IgA mediated immune hemolysis. The diagnosis strategy of autoimmune hemolytic anaemia associated with negative direct antiglobulin test and the potential links between autoimmune hemolytic anaemia and HCV are discussed.
M3 - SCORING: Zeitschriftenaufsatz
VL - 29
SP - 135
EP - 138
JO - REV MED INTERNE
JF - REV MED INTERNE
SN - 0248-8663
IS - 2
M1 - 2
ER -
