IFN-γ release assay versus tuberculin skin test for monitoring TB infection in healthcare workers

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IFN-γ release assay versus tuberculin skin test for monitoring TB infection in healthcare workers. / Nienhaus, Albert; Ringshausen, Felix C; Costa, José Torres; Schablon, Anja; Tripodi, Dominique.

in: EXPERT REV ANTI-INFE, Jahrgang 11, Nr. 1, 01.01.2013, S. 37-48.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{d468dcbe1cb64f64aafe2c4a0f0b4512,
title = "IFN-γ release assay versus tuberculin skin test for monitoring TB infection in healthcare workers",
abstract = "Healthcare workers (HCW) are a risk group for TB. Even in countries with low TB incidence, the risk of TB in HCW is elevated for a wide range of tasks in healthcare, and the prevention of nosocomial infection of HCW remains as a challenge. IFN-γ release assays (IGRA) facilitate the screening of HCW for latent TB infection. In comparison with the tuberculin skin test, the IGRA reduces the number of x-rays and the amount of chemoprevention needed. However, a borderline zone should be introduced for the interpretation of IGRA results in the serial testing of HCW. More data on disease progression depending on conversion and reversion in IGRA is needed and a better test, which is able to distinguish recent from remote latent TB infection, would be desirable in the future.",
keywords = "Health Personnel, Humans, Interferon-gamma Release Tests, Mass Screening, Mycobacterium tuberculosis, Tuberculin Test, Tuberculosis",
author = "Albert Nienhaus and Ringshausen, {Felix C} and Costa, {Jos{\'e} Torres} and Anja Schablon and Dominique Tripodi",
year = "2013",
month = jan,
day = "1",
doi = "10.1586/eri.12.150",
language = "English",
volume = "11",
pages = "37--48",
journal = "EXPERT REV ANTI-INFE",
issn = "1478-7210",
publisher = "EXPERT REVIEWS",
number = "1",

}

RIS

TY - JOUR

T1 - IFN-γ release assay versus tuberculin skin test for monitoring TB infection in healthcare workers

AU - Nienhaus, Albert

AU - Ringshausen, Felix C

AU - Costa, José Torres

AU - Schablon, Anja

AU - Tripodi, Dominique

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Healthcare workers (HCW) are a risk group for TB. Even in countries with low TB incidence, the risk of TB in HCW is elevated for a wide range of tasks in healthcare, and the prevention of nosocomial infection of HCW remains as a challenge. IFN-γ release assays (IGRA) facilitate the screening of HCW for latent TB infection. In comparison with the tuberculin skin test, the IGRA reduces the number of x-rays and the amount of chemoprevention needed. However, a borderline zone should be introduced for the interpretation of IGRA results in the serial testing of HCW. More data on disease progression depending on conversion and reversion in IGRA is needed and a better test, which is able to distinguish recent from remote latent TB infection, would be desirable in the future.

AB - Healthcare workers (HCW) are a risk group for TB. Even in countries with low TB incidence, the risk of TB in HCW is elevated for a wide range of tasks in healthcare, and the prevention of nosocomial infection of HCW remains as a challenge. IFN-γ release assays (IGRA) facilitate the screening of HCW for latent TB infection. In comparison with the tuberculin skin test, the IGRA reduces the number of x-rays and the amount of chemoprevention needed. However, a borderline zone should be introduced for the interpretation of IGRA results in the serial testing of HCW. More data on disease progression depending on conversion and reversion in IGRA is needed and a better test, which is able to distinguish recent from remote latent TB infection, would be desirable in the future.

KW - Health Personnel

KW - Humans

KW - Interferon-gamma Release Tests

KW - Mass Screening

KW - Mycobacterium tuberculosis

KW - Tuberculin Test

KW - Tuberculosis

U2 - 10.1586/eri.12.150

DO - 10.1586/eri.12.150

M3 - SCORING: Journal article

C2 - 23428101

VL - 11

SP - 37

EP - 48

JO - EXPERT REV ANTI-INFE

JF - EXPERT REV ANTI-INFE

SN - 1478-7210

IS - 1

ER -