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Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations

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Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations. / Kuklik, Pawel; Zeemering, Stef; van Hunnik, Arne; Maesen, Bart; Pison, Laurent; Lau, Dennis H; Maessen, Jos; Podziemski, Piotr; Meyer, Christian; Schaffer, Benjamin; Crijns, Harry; Willems, Stephan; Schotten, Ulrich.

in: IEEE T BIO-MED ENG, Jahrgang 64, Nr. 2, 02.2017, S. 310-318.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kuklik, P, Zeemering, S, van Hunnik, A, Maesen, B, Pison, L, Lau, DH, Maessen, J, Podziemski, P, Meyer, C, Schaffer, B, Crijns, H, Willems, S & Schotten, U 2017, 'Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations', IEEE T BIO-MED ENG, Jg. 64, Nr. 2, S. 310-318. https://doi.org/10.1109/TBME.2016.2554660

APA

Kuklik, P., Zeemering, S., van Hunnik, A., Maesen, B., Pison, L., Lau, D. H., Maessen, J., Podziemski, P., Meyer, C., Schaffer, B., Crijns, H., Willems, S., & Schotten, U. (2017). Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations. IEEE T BIO-MED ENG, 64(2), 310-318. https://doi.org/10.1109/TBME.2016.2554660

Vancouver

Kuklik P, Zeemering S, van Hunnik A, Maesen B, Pison L, Lau DH et al. Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations. IEEE T BIO-MED ENG. 2017 Feb;64(2):310-318. https://doi.org/10.1109/TBME.2016.2554660

Bibtex

@article{706aff6517ab400fabf2a7f2c010bfb2,
title = "Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations",
abstract = "OBJECTIVE: To explore technical challenges of phase singularity (PS) mapping during atrial fibrillation (AF) using direct contact electrograms.METHODS: AF mapping was performed in high-density epicardial recordings of human paroxysmal (PAF) or persistent (PersAF) (N = 20 pts) AF with an array of 16 × 16 electrodes placed on atrial epicardium. PS points were detected using subsets of electrodes forming rings of varying sizes.RESULTS: PS detection using a 2 × 2 electrode ring identified 0.88 ± 1.00 PS/s in PAF group and 3.91 ± 2.51 per s in PersAF group (p < 0.001) in 2.4 × 2.4 cm mapping area. All detected PS had a short lifespan with the longest being 1100 ms (6.8 rotations). Exploration of the PS detection in a numerical model demonstrated that at least eight electrodes are required to avoid frequent false positive PS detection due to chance. Application of a detection grid consisting a double ring of electrodes (2 × 2 and 4 × 4 rings) decreased the number of false positive detections. The double ring was more resilient to electrode swapping (with just three instances of false positives versus 4380 false positives using 2 × 2 ring).CONCLUSIONS: The number of detected rotors critically depends upon the parameters of the detection algorithm, especially the number of electrodes used to detect PS. Based on our results, we recommend double ring comprised of 2 × 2 and 4 × 4 grid of electrodes for robust rotor detection.SIGNIFICANCE: Great methodological care has to be taken before equating detected PS with rotating waves and using PS detection algorithms to guide catheter ablation of AF.",
keywords = "Algorithms, Atrial Fibrillation/physiopathology, Body Surface Potential Mapping/methods, Catheter Ablation/methods, Electrophysiologic Techniques, Cardiac/methods, Humans, Models, Cardiovascular",
author = "Pawel Kuklik and Stef Zeemering and {van Hunnik}, Arne and Bart Maesen and Laurent Pison and Lau, {Dennis H} and Jos Maessen and Piotr Podziemski and Christian Meyer and Benjamin Schaffer and Harry Crijns and Stephan Willems and Ulrich Schotten",
year = "2017",
month = feb,
doi = "10.1109/TBME.2016.2554660",
language = "English",
volume = "64",
pages = "310--318",
journal = "IEEE T BIO-MED ENG",
issn = "0018-9294",
publisher = "IEEE Computer Society",
number = "2",

}

RIS

TY - JOUR

T1 - Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations

AU - Kuklik, Pawel

AU - Zeemering, Stef

AU - van Hunnik, Arne

AU - Maesen, Bart

AU - Pison, Laurent

AU - Lau, Dennis H

AU - Maessen, Jos

AU - Podziemski, Piotr

AU - Meyer, Christian

AU - Schaffer, Benjamin

AU - Crijns, Harry

AU - Willems, Stephan

AU - Schotten, Ulrich

PY - 2017/2

Y1 - 2017/2

N2 - OBJECTIVE: To explore technical challenges of phase singularity (PS) mapping during atrial fibrillation (AF) using direct contact electrograms.METHODS: AF mapping was performed in high-density epicardial recordings of human paroxysmal (PAF) or persistent (PersAF) (N = 20 pts) AF with an array of 16 × 16 electrodes placed on atrial epicardium. PS points were detected using subsets of electrodes forming rings of varying sizes.RESULTS: PS detection using a 2 × 2 electrode ring identified 0.88 ± 1.00 PS/s in PAF group and 3.91 ± 2.51 per s in PersAF group (p < 0.001) in 2.4 × 2.4 cm mapping area. All detected PS had a short lifespan with the longest being 1100 ms (6.8 rotations). Exploration of the PS detection in a numerical model demonstrated that at least eight electrodes are required to avoid frequent false positive PS detection due to chance. Application of a detection grid consisting a double ring of electrodes (2 × 2 and 4 × 4 rings) decreased the number of false positive detections. The double ring was more resilient to electrode swapping (with just three instances of false positives versus 4380 false positives using 2 × 2 ring).CONCLUSIONS: The number of detected rotors critically depends upon the parameters of the detection algorithm, especially the number of electrodes used to detect PS. Based on our results, we recommend double ring comprised of 2 × 2 and 4 × 4 grid of electrodes for robust rotor detection.SIGNIFICANCE: Great methodological care has to be taken before equating detected PS with rotating waves and using PS detection algorithms to guide catheter ablation of AF.

AB - OBJECTIVE: To explore technical challenges of phase singularity (PS) mapping during atrial fibrillation (AF) using direct contact electrograms.METHODS: AF mapping was performed in high-density epicardial recordings of human paroxysmal (PAF) or persistent (PersAF) (N = 20 pts) AF with an array of 16 × 16 electrodes placed on atrial epicardium. PS points were detected using subsets of electrodes forming rings of varying sizes.RESULTS: PS detection using a 2 × 2 electrode ring identified 0.88 ± 1.00 PS/s in PAF group and 3.91 ± 2.51 per s in PersAF group (p < 0.001) in 2.4 × 2.4 cm mapping area. All detected PS had a short lifespan with the longest being 1100 ms (6.8 rotations). Exploration of the PS detection in a numerical model demonstrated that at least eight electrodes are required to avoid frequent false positive PS detection due to chance. Application of a detection grid consisting a double ring of electrodes (2 × 2 and 4 × 4 rings) decreased the number of false positive detections. The double ring was more resilient to electrode swapping (with just three instances of false positives versus 4380 false positives using 2 × 2 ring).CONCLUSIONS: The number of detected rotors critically depends upon the parameters of the detection algorithm, especially the number of electrodes used to detect PS. Based on our results, we recommend double ring comprised of 2 × 2 and 4 × 4 grid of electrodes for robust rotor detection.SIGNIFICANCE: Great methodological care has to be taken before equating detected PS with rotating waves and using PS detection algorithms to guide catheter ablation of AF.

KW - Algorithms

KW - Atrial Fibrillation/physiopathology

KW - Body Surface Potential Mapping/methods

KW - Catheter Ablation/methods

KW - Electrophysiologic Techniques, Cardiac/methods

KW - Humans

KW - Models, Cardiovascular

U2 - 10.1109/TBME.2016.2554660

DO - 10.1109/TBME.2016.2554660

M3 - SCORING: Journal article

C2 - 27101596

VL - 64

SP - 310

EP - 318

JO - IEEE T BIO-MED ENG

JF - IEEE T BIO-MED ENG

SN - 0018-9294

IS - 2

ER -