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Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif

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Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. / Altfeld, Marcus; Livingston, B; Reshamwala, N; Nguyen, P T; Addo, M M; Shea, A; Newman, M; Fikes, J; Sidney, J; Wentworth, P; Chesnut, R; Eldridge, R L; Rosenberg, E S; Robbins, G K; Brander, C; Sax, P E; Boswell, S; Flynn, T; Buchbinder, S; Goulder, P J; Walker, B D; Sette, A; Kalams, S A.

in: J VIROL, Jahrgang 75, Nr. 3, 02.2001, S. 1301-11.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Altfeld, M, Livingston, B, Reshamwala, N, Nguyen, PT, Addo, MM, Shea, A, Newman, M, Fikes, J, Sidney, J, Wentworth, P, Chesnut, R, Eldridge, RL, Rosenberg, ES, Robbins, GK, Brander, C, Sax, PE, Boswell, S, Flynn, T, Buchbinder, S, Goulder, PJ, Walker, BD, Sette, A & Kalams, SA 2001, 'Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif', J VIROL, Jg. 75, Nr. 3, S. 1301-11. https://doi.org/10.1128/JVI.75.3.1301-1311.2001

APA

Altfeld, M., Livingston, B., Reshamwala, N., Nguyen, P. T., Addo, M. M., Shea, A., Newman, M., Fikes, J., Sidney, J., Wentworth, P., Chesnut, R., Eldridge, R. L., Rosenberg, E. S., Robbins, G. K., Brander, C., Sax, P. E., Boswell, S., Flynn, T., Buchbinder, S., ... Kalams, S. A. (2001). Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J VIROL, 75(3), 1301-11. https://doi.org/10.1128/JVI.75.3.1301-1311.2001

Vancouver

Altfeld M, Livingston B, Reshamwala N, Nguyen PT, Addo MM, Shea A et al. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J VIROL. 2001 Feb;75(3):1301-11. https://doi.org/10.1128/JVI.75.3.1301-1311.2001

Bibtex

@article{a0d9bd513d0247cfaf976f5626d5e16b,
title = "Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif",
abstract = "Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and prophylactic HIV-1 vaccines. The identification of virus-specific epitopes that are efficiently recognized by CTL is the first step in the development of future vaccines. Here we describe the immunological characterization of a number of novel HIV-1-specific, HLA-A2-restricted CTL epitopes that share a high degree of conservation within HIV-1 and a strong binding to different alleles of the HLA-A2 superfamily. These novel epitopes include the first reported CTL epitope in the Vpr protein. Two of the novel epitopes were immunodominant among the HLA-A2-restricted CTL responses of individuals with acute and chronic HIV-1 infection. The novel CTL epitopes identified here should be included in future vaccines designed to induce HIV-1-specific CTL responses restricted by the HLA-A2 superfamily and will be important to assess in immunogenicity studies in infected persons and in uninfected recipients of candidate HIV-1 vaccines.",
keywords = "Acquired Immunodeficiency Syndrome/immunology, Binding Sites, Cell Line, Epitopes, T-Lymphocyte, Gene Products, vpr/immunology, HIV-1/immunology, HLA-A2 Antigen/physiology, Humans, T-Lymphocytes, Cytotoxic/immunology, vpr Gene Products, Human Immunodeficiency Virus",
author = "Marcus Altfeld and B Livingston and N Reshamwala and Nguyen, {P T} and Addo, {M M} and A Shea and M Newman and J Fikes and J Sidney and P Wentworth and R Chesnut and Eldridge, {R L} and Rosenberg, {E S} and Robbins, {G K} and C Brander and Sax, {P E} and S Boswell and T Flynn and S Buchbinder and Goulder, {P J} and Walker, {B D} and A Sette and Kalams, {S A}",
year = "2001",
month = feb,
doi = "10.1128/JVI.75.3.1301-1311.2001",
language = "English",
volume = "75",
pages = "1301--11",
journal = "J VIROL",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "3",

}

RIS

TY - JOUR

T1 - Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif

AU - Altfeld, Marcus

AU - Livingston, B

AU - Reshamwala, N

AU - Nguyen, P T

AU - Addo, M M

AU - Shea, A

AU - Newman, M

AU - Fikes, J

AU - Sidney, J

AU - Wentworth, P

AU - Chesnut, R

AU - Eldridge, R L

AU - Rosenberg, E S

AU - Robbins, G K

AU - Brander, C

AU - Sax, P E

AU - Boswell, S

AU - Flynn, T

AU - Buchbinder, S

AU - Goulder, P J

AU - Walker, B D

AU - Sette, A

AU - Kalams, S A

PY - 2001/2

Y1 - 2001/2

N2 - Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and prophylactic HIV-1 vaccines. The identification of virus-specific epitopes that are efficiently recognized by CTL is the first step in the development of future vaccines. Here we describe the immunological characterization of a number of novel HIV-1-specific, HLA-A2-restricted CTL epitopes that share a high degree of conservation within HIV-1 and a strong binding to different alleles of the HLA-A2 superfamily. These novel epitopes include the first reported CTL epitope in the Vpr protein. Two of the novel epitopes were immunodominant among the HLA-A2-restricted CTL responses of individuals with acute and chronic HIV-1 infection. The novel CTL epitopes identified here should be included in future vaccines designed to induce HIV-1-specific CTL responses restricted by the HLA-A2 superfamily and will be important to assess in immunogenicity studies in infected persons and in uninfected recipients of candidate HIV-1 vaccines.

AB - Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and prophylactic HIV-1 vaccines. The identification of virus-specific epitopes that are efficiently recognized by CTL is the first step in the development of future vaccines. Here we describe the immunological characterization of a number of novel HIV-1-specific, HLA-A2-restricted CTL epitopes that share a high degree of conservation within HIV-1 and a strong binding to different alleles of the HLA-A2 superfamily. These novel epitopes include the first reported CTL epitope in the Vpr protein. Two of the novel epitopes were immunodominant among the HLA-A2-restricted CTL responses of individuals with acute and chronic HIV-1 infection. The novel CTL epitopes identified here should be included in future vaccines designed to induce HIV-1-specific CTL responses restricted by the HLA-A2 superfamily and will be important to assess in immunogenicity studies in infected persons and in uninfected recipients of candidate HIV-1 vaccines.

KW - Acquired Immunodeficiency Syndrome/immunology

KW - Binding Sites

KW - Cell Line

KW - Epitopes, T-Lymphocyte

KW - Gene Products, vpr/immunology

KW - HIV-1/immunology

KW - HLA-A2 Antigen/physiology

KW - Humans

KW - T-Lymphocytes, Cytotoxic/immunology

KW - vpr Gene Products, Human Immunodeficiency Virus

U2 - 10.1128/JVI.75.3.1301-1311.2001

DO - 10.1128/JVI.75.3.1301-1311.2001

M3 - SCORING: Journal article

C2 - 11152503

VL - 75

SP - 1301

EP - 1311

JO - J VIROL

JF - J VIROL

SN - 0022-538X

IS - 3

ER -