Identification of nine new susceptibility loci for endometrial cancer
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Identification of nine new susceptibility loci for endometrial cancer. / O'Mara, Tracy A; Glubb, Dylan M; Amant, Frederic; Annibali, Daniela; Ashton, Katie; Attia, John; Auer, Paul L; Beckmann, Matthias W; Black, Amanda; Bolla, Manjeet K; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Buchanan, Daniel D; Burwinkel, Barbara; Chang-Claude, Jenny; Chanock, Stephen J; Chen, Chu; Chen, Maxine M; Cheng, Timothy H T; Clarke, Christine L; Clendenning, Mark; Cook, Linda S; Couch, Fergus J; Cox, Angela; Crous-Bous, Marta; Czene, Kamila; Day, Felix; Dennis, Joe; Depreeuw, Jeroen; Doherty, Jennifer Anne; Dörk, Thilo; Dowdy, Sean C; Dürst, Matthias; Ekici, Arif B; Fasching, Peter A; Fridley, Brooke L; Friedenreich, Christine M; Fritschi, Lin; Fung, Jenny; García-Closas, Montserrat; Gaudet, Mia M; Giles, Graham G; Goode, Ellen L; Gorman, Maggie; Haiman, Christopher A; Hall, Per; Hankison, Susan E; Healey, Catherine S; Hein, Alexander; Hillemanns, Peter; Hodgson, Shirley; Hoivik, Erling A; Holliday, Elizabeth G; Hopper, John L; Hunter, David J; Jones, Angela; Krakstad, Camilla; Kristensen, Vessela N; Lambrechts, Diether; Marchand, Loic Le; Liang, Xiaolin; Lindblom, Annika; Lissowska, Jolanta; Long, Jirong; Lu, Lingeng; Magliocco, Anthony M; Martin, Lynn; McEvoy, Mark; Meindl, Alfons; Michailidou, Kyriaki; Milne, Roger L; Mints, Miriam; Montgomery, Grant W; Nassir, Rami; Olsson, Håkan; Orlow, Irene; Otton, Geoffrey; Palles, Claire; Perry, John R B; Peto, Julian; Pooler, Loreall; Prescott, Jennifer; Proietto, Tony; Rebbeck, Timothy R; Risch, Harvey A; Rogers, Peter A W; Rübner, Matthias; Runnebaum, Ingo; Sacerdote, Carlotta; Sarto, Gloria E; Schumacher, Fredrick; Scott, Rodney J; Setiawan, V Wendy; Shah, Mitul; Sheng, Xin; Shu, Xiao-Ou; Southey, Melissa C; Swerdlow, Anthony J; Tham, Emma; Trovik, Jone; Turman, Constance; Tyrer, Jonathan P; Vachon, Celine; VanDen Berg, David; Vanderstichele, Adriaan; Wang, Zhaoming; Webb, Penelope M; Wentzensen, Nicolas; Werner, Henrica M J; Winham, Stacey J; Wolk, Alicja; Xia, Lucy; Xiang, Yong-Bing; Yang, Hannah P; Yu, Herbert; Zheng, Wei; Pharoah, Paul D P; Dunning, Alison M; Kraft, Peter; De Vivo, Immaculata; Tomlinson, Ian; Easton, Douglas F; Spurdle, Amanda B; Thompson, Deborah J.
in: NAT COMMUN, Jahrgang 9, Nr. 1, 09.08.2018, S. 3166.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Identification of nine new susceptibility loci for endometrial cancer
AU - O'Mara, Tracy A
AU - Glubb, Dylan M
AU - Amant, Frederic
AU - Annibali, Daniela
AU - Ashton, Katie
AU - Attia, John
AU - Auer, Paul L
AU - Beckmann, Matthias W
AU - Black, Amanda
AU - Bolla, Manjeet K
AU - Brauch, Hiltrud
AU - Brenner, Hermann
AU - Brinton, Louise
AU - Buchanan, Daniel D
AU - Burwinkel, Barbara
AU - Chang-Claude, Jenny
AU - Chanock, Stephen J
AU - Chen, Chu
AU - Chen, Maxine M
AU - Cheng, Timothy H T
AU - Clarke, Christine L
AU - Clendenning, Mark
AU - Cook, Linda S
AU - Couch, Fergus J
AU - Cox, Angela
AU - Crous-Bous, Marta
AU - Czene, Kamila
AU - Day, Felix
AU - Dennis, Joe
AU - Depreeuw, Jeroen
AU - Doherty, Jennifer Anne
AU - Dörk, Thilo
AU - Dowdy, Sean C
AU - Dürst, Matthias
AU - Ekici, Arif B
AU - Fasching, Peter A
AU - Fridley, Brooke L
AU - Friedenreich, Christine M
AU - Fritschi, Lin
AU - Fung, Jenny
AU - García-Closas, Montserrat
AU - Gaudet, Mia M
AU - Giles, Graham G
AU - Goode, Ellen L
AU - Gorman, Maggie
AU - Haiman, Christopher A
AU - Hall, Per
AU - Hankison, Susan E
AU - Healey, Catherine S
AU - Hein, Alexander
AU - Hillemanns, Peter
AU - Hodgson, Shirley
AU - Hoivik, Erling A
AU - Holliday, Elizabeth G
AU - Hopper, John L
AU - Hunter, David J
AU - Jones, Angela
AU - Krakstad, Camilla
AU - Kristensen, Vessela N
AU - Lambrechts, Diether
AU - Marchand, Loic Le
AU - Liang, Xiaolin
AU - Lindblom, Annika
AU - Lissowska, Jolanta
AU - Long, Jirong
AU - Lu, Lingeng
AU - Magliocco, Anthony M
AU - Martin, Lynn
AU - McEvoy, Mark
AU - Meindl, Alfons
AU - Michailidou, Kyriaki
AU - Milne, Roger L
AU - Mints, Miriam
AU - Montgomery, Grant W
AU - Nassir, Rami
AU - Olsson, Håkan
AU - Orlow, Irene
AU - Otton, Geoffrey
AU - Palles, Claire
AU - Perry, John R B
AU - Peto, Julian
AU - Pooler, Loreall
AU - Prescott, Jennifer
AU - Proietto, Tony
AU - Rebbeck, Timothy R
AU - Risch, Harvey A
AU - Rogers, Peter A W
AU - Rübner, Matthias
AU - Runnebaum, Ingo
AU - Sacerdote, Carlotta
AU - Sarto, Gloria E
AU - Schumacher, Fredrick
AU - Scott, Rodney J
AU - Setiawan, V Wendy
AU - Shah, Mitul
AU - Sheng, Xin
AU - Shu, Xiao-Ou
AU - Southey, Melissa C
AU - Swerdlow, Anthony J
AU - Tham, Emma
AU - Trovik, Jone
AU - Turman, Constance
AU - Tyrer, Jonathan P
AU - Vachon, Celine
AU - VanDen Berg, David
AU - Vanderstichele, Adriaan
AU - Wang, Zhaoming
AU - Webb, Penelope M
AU - Wentzensen, Nicolas
AU - Werner, Henrica M J
AU - Winham, Stacey J
AU - Wolk, Alicja
AU - Xia, Lucy
AU - Xiang, Yong-Bing
AU - Yang, Hannah P
AU - Yu, Herbert
AU - Zheng, Wei
AU - Pharoah, Paul D P
AU - Dunning, Alison M
AU - Kraft, Peter
AU - De Vivo, Immaculata
AU - Tomlinson, Ian
AU - Easton, Douglas F
AU - Spurdle, Amanda B
AU - Thompson, Deborah J
PY - 2018/8/9
Y1 - 2018/8/9
N2 - Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
AB - Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.
KW - Journal Article
U2 - 10.1038/s41467-018-05427-7
DO - 10.1038/s41467-018-05427-7
M3 - SCORING: Journal article
C2 - 30093612
VL - 9
SP - 3166
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -