Identification of Kosakonia cowanii as a rare cause of acute cholecystitis:case report and review of the literature
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Identification of Kosakonia cowanii as a rare cause of acute cholecystitis:case report and review of the literature. / Berinson, Benjamin; Bellon, Eugen; Christner, Martin; Both, Anna; Aepfelbacher, Martin; Rohde, Holger.
in: BMC INFECT DIS, Jahrgang 20, Nr. 1, 24.05.2020, S. 366.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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T1 - Identification of Kosakonia cowanii as a rare cause of acute cholecystitis:case report and review of the literature
AU - Berinson, Benjamin
AU - Bellon, Eugen
AU - Christner, Martin
AU - Both, Anna
AU - Aepfelbacher, Martin
AU - Rohde, Holger
PY - 2020/5/24
Y1 - 2020/5/24
N2 - BACKGROUND: Kosakonia cowanii, formerly known as Enterobacter cowanii, is a Gram-negative bacillus belonging to the order Enterobacterales. The species is usually recognized as a plant pathogen and has only anecdotally been encountered as a human pathogen. Here we describe the rare case of a K. cowanii infection presenting as an acute cholecystitis and provide a review of available literature. Evident difficulties in species identification by biochemical profiling suggests that potentially, K. cowanii might represent an underestimated human pathogen.CASE PRESENTATION: A 61-year old immunocompromised man presented to the hospital with fever and pain in the upper right abdomen. Sonography revealed an inflamed gall bladder and several gall stones. A cholecystectomy proved diagnosis of an acute cholecystitis with a partial necrosis of the gall bladder. Surgical specimen grew pure cultures of Gram-negative rods unambiguously identified as K. cowanii by MALDI-TOF, 16S-rRNA analysis and whole genome sequencing.CONCLUSIONS: Reporting cases of Kosakonia species can shed light on the prevalence and clinical importance of this rare cause of human infection. Our case is the first to describe an infection without prior traumatic inoculation of the pathogen from its usual habitat, a plant, to the patient. This raises the question of the route of infections as well as the pathogen's ability to colonize the human gut.
AB - BACKGROUND: Kosakonia cowanii, formerly known as Enterobacter cowanii, is a Gram-negative bacillus belonging to the order Enterobacterales. The species is usually recognized as a plant pathogen and has only anecdotally been encountered as a human pathogen. Here we describe the rare case of a K. cowanii infection presenting as an acute cholecystitis and provide a review of available literature. Evident difficulties in species identification by biochemical profiling suggests that potentially, K. cowanii might represent an underestimated human pathogen.CASE PRESENTATION: A 61-year old immunocompromised man presented to the hospital with fever and pain in the upper right abdomen. Sonography revealed an inflamed gall bladder and several gall stones. A cholecystectomy proved diagnosis of an acute cholecystitis with a partial necrosis of the gall bladder. Surgical specimen grew pure cultures of Gram-negative rods unambiguously identified as K. cowanii by MALDI-TOF, 16S-rRNA analysis and whole genome sequencing.CONCLUSIONS: Reporting cases of Kosakonia species can shed light on the prevalence and clinical importance of this rare cause of human infection. Our case is the first to describe an infection without prior traumatic inoculation of the pathogen from its usual habitat, a plant, to the patient. This raises the question of the route of infections as well as the pathogen's ability to colonize the human gut.
KW - Cholecystectomy
KW - Cholecystitis, Acute/diagnosis
KW - Enterobacteriaceae/genetics
KW - Enterobacteriaceae Infections/diagnosis
KW - Gallbladder/pathology
KW - Gallstones/surgery
KW - Humans
KW - Immunocompromised Host
KW - Male
KW - Middle Aged
KW - Necrosis
KW - RNA, Bacterial/genetics
KW - RNA, Ribosomal, 16S/genetics
KW - Rare Diseases/diagnosis
KW - Treatment Outcome
KW - Whole Genome Sequencing
U2 - 10.1186/s12879-020-05084-6
DO - 10.1186/s12879-020-05084-6
M3 - SCORING: Review article
C2 - 32448208
VL - 20
SP - 366
JO - BMC INFECT DIS
JF - BMC INFECT DIS
SN - 1471-2334
IS - 1
ER -