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Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.

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Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. / Lugthart, Sanne; Cheok, Meyling H; Boer, den; Monique, L; Yang, Wenjian; Holleman, Amy; Cheng, Cheng; Pui, Ching-Hon; Janka-Schaub, Gritta; Janka-Schaub, Gritta E; Pieters, Rob; Evans, William E.

in: CANCER CELL, Jahrgang 7, Nr. 4, 4, 2005, S. 375-386.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lugthart, S, Cheok, MH, Boer, D, Monique, L, Yang, W, Holleman, A, Cheng, C, Pui, C-H, Janka-Schaub, G, Janka-Schaub, GE, Pieters, R & Evans, WE 2005, 'Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.', CANCER CELL, Jg. 7, Nr. 4, 4, S. 375-386. <http://www.ncbi.nlm.nih.gov/pubmed/15837626?dopt=Citation>

APA

Lugthart, S., Cheok, M. H., Boer, D., Monique, L., Yang, W., Holleman, A., Cheng, C., Pui, C-H., Janka-Schaub, G., Janka-Schaub, G. E., Pieters, R., & Evans, W. E. (2005). Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. CANCER CELL, 7(4), 375-386. [4]. http://www.ncbi.nlm.nih.gov/pubmed/15837626?dopt=Citation

Vancouver

Lugthart S, Cheok MH, Boer D, Monique L, Yang W, Holleman A et al. Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. CANCER CELL. 2005;7(4):375-386. 4.

Bibtex

@article{49c698ebea5449f2acc95a8ec9759d43,
title = "Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.",
abstract = "Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients and used a genome-wide approach to identify 45 genes differentially expressed in ALL exhibiting crossresistance to prednisolone, vincristine, asparaginase, and daunorubicin. We also identified a distinct phenotype of discordant resistance to asparaginase and vincristine and 139 genes whose expression was associated with this novel phenotype. The expression of these genes discriminated treatment outcome in two independent patient populations, identifying a subset of patients with a markedly inferior outcome (37% +/- 13% 5 year DFS).",
author = "Sanne Lugthart and Cheok, {Meyling H} and den Boer and L Monique and Wenjian Yang and Amy Holleman and Cheng Cheng and Ching-Hon Pui and Gritta Janka-Schaub and Janka-Schaub, {Gritta E} and Rob Pieters and Evans, {William E}",
year = "2005",
language = "Deutsch",
volume = "7",
pages = "375--386",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.

AU - Lugthart, Sanne

AU - Cheok, Meyling H

AU - Boer, den

AU - Monique, L

AU - Yang, Wenjian

AU - Holleman, Amy

AU - Cheng, Cheng

AU - Pui, Ching-Hon

AU - Janka-Schaub, Gritta

AU - Janka-Schaub, Gritta E

AU - Pieters, Rob

AU - Evans, William E

PY - 2005

Y1 - 2005

N2 - Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients and used a genome-wide approach to identify 45 genes differentially expressed in ALL exhibiting crossresistance to prednisolone, vincristine, asparaginase, and daunorubicin. We also identified a distinct phenotype of discordant resistance to asparaginase and vincristine and 139 genes whose expression was associated with this novel phenotype. The expression of these genes discriminated treatment outcome in two independent patient populations, identifying a subset of patients with a markedly inferior outcome (37% +/- 13% 5 year DFS).

AB - Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients and used a genome-wide approach to identify 45 genes differentially expressed in ALL exhibiting crossresistance to prednisolone, vincristine, asparaginase, and daunorubicin. We also identified a distinct phenotype of discordant resistance to asparaginase and vincristine and 139 genes whose expression was associated with this novel phenotype. The expression of these genes discriminated treatment outcome in two independent patient populations, identifying a subset of patients with a markedly inferior outcome (37% +/- 13% 5 year DFS).

M3 - SCORING: Zeitschriftenaufsatz

VL - 7

SP - 375

EP - 386

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 4

M1 - 4

ER -