Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events

Caoimhe E O'Brien; Bing Zhai; Mihaela Ola; Sean A Bergin; Eoin Ó Cinnéide; Ísla O'Connor; Thierry Rolling; Edwin Miranda; N Esther Babady; Tobias M Hohl; Geraldine Butler

doi:10.1093/g3journal/jkab367

Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events

Standard

Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events. / O'Brien, Caoimhe E; Zhai, Bing; Ola, Mihaela; Bergin, Sean A; Ó Cinnéide, Eoin; O'Connor, Ísla; Rolling, Thierry; Miranda, Edwin; Babady, N Esther; Hohl, Tobias M; Butler, Geraldine.

in: G3-GENES GENOM GENET, Jahrgang 12, Nr. 1, jkab367, 04.01.2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

O'Brien, CE, Zhai, B, Ola, M, Bergin, SA, Ó Cinnéide, E, O'Connor, Í, Rolling, T, Miranda, E, Babady, NE, Hohl, TM & Butler, G 2022, 'Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events', G3-GENES GENOM GENET, Jg. 12, Nr. 1, jkab367. https://doi.org/10.1093/g3journal/jkab367

APA

O'Brien, C. E., Zhai, B., Ola, M., Bergin, S. A., Ó Cinnéide, E., O'Connor, Í., Rolling, T., Miranda, E., Babady, N. E., Hohl, T. M., & Butler, G. (2022). Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events. G3-GENES GENOM GENET, 12(1), [jkab367]. https://doi.org/10.1093/g3journal/jkab367

Vancouver

O'Brien CE, Zhai B, Ola M, Bergin SA, Ó Cinnéide E, O'Connor Í et al. Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events. G3-GENES GENOM GENET. 2022 Jan 4;12(1). jkab367. https://doi.org/10.1093/g3journal/jkab367

Bibtex

@article{d1a3888beb5244caa42fd14f468b2f44,

title = "Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events",

abstract = "Candida metapsilosis is a member of the Candida parapsilosis species complex, a group of opportunistic human pathogens. Of all the members of this complex, C. metapsilosis is the least virulent, and accounts for a small proportion of invasive Candida infections. Previous studies established that all C. metapsilosis isolates are hybrids, originating from a single hybridization event between two lineages, parent A and parent B. Here, we use MinION and Illumina sequencing to characterize a C. metapsilosis isolate that originated from a separate hybridization. One of the parents of the new isolate is very closely related to parent A. However, the other parent (parent C) is not the same as parent B. Unlike C. metapsilosis AB isolates, the C. metapsilosis AC isolate has not undergone introgression at the mating type-like locus. In addition, the A and C haplotypes are not fully collinear. The C. metapsilosis AC isolate has undergone loss of heterozygosity with a preference for haplotype A, indicating that this isolate is in the early stages of genome stabilization.",

author = "O'Brien, {Caoimhe E} and Bing Zhai and Mihaela Ola and Bergin, {Sean A} and {{\'O} Cinn{\'e}ide}, Eoin and {\'I}sla O'Connor and Thierry Rolling and Edwin Miranda and Babady, {N Esther} and Hohl, {Tobias M} and Geraldine Butler",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.",

year = "2022",

month = jan,

day = "4",

doi = "10.1093/g3journal/jkab367",

language = "English",

volume = "12",

journal = "G3-GENES GENOM GENET",

issn = "2160-1836",

publisher = "Genetics Society of America",

number = "1",

}

RIS

TY - JOUR

T1 - Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events

AU - O'Brien, Caoimhe E

AU - Zhai, Bing

AU - Ola, Mihaela

AU - Bergin, Sean A

AU - Ó Cinnéide, Eoin

AU - O'Connor, Ísla

AU - Rolling, Thierry

AU - Miranda, Edwin

AU - Babady, N Esther

AU - Hohl, Tobias M

AU - Butler, Geraldine

PY - 2022/1/4

Y1 - 2022/1/4

N2 - Candida metapsilosis is a member of the Candida parapsilosis species complex, a group of opportunistic human pathogens. Of all the members of this complex, C. metapsilosis is the least virulent, and accounts for a small proportion of invasive Candida infections. Previous studies established that all C. metapsilosis isolates are hybrids, originating from a single hybridization event between two lineages, parent A and parent B. Here, we use MinION and Illumina sequencing to characterize a C. metapsilosis isolate that originated from a separate hybridization. One of the parents of the new isolate is very closely related to parent A. However, the other parent (parent C) is not the same as parent B. Unlike C. metapsilosis AB isolates, the C. metapsilosis AC isolate has not undergone introgression at the mating type-like locus. In addition, the A and C haplotypes are not fully collinear. The C. metapsilosis AC isolate has undergone loss of heterozygosity with a preference for haplotype A, indicating that this isolate is in the early stages of genome stabilization.

AB - Candida metapsilosis is a member of the Candida parapsilosis species complex, a group of opportunistic human pathogens. Of all the members of this complex, C. metapsilosis is the least virulent, and accounts for a small proportion of invasive Candida infections. Previous studies established that all C. metapsilosis isolates are hybrids, originating from a single hybridization event between two lineages, parent A and parent B. Here, we use MinION and Illumina sequencing to characterize a C. metapsilosis isolate that originated from a separate hybridization. One of the parents of the new isolate is very closely related to parent A. However, the other parent (parent C) is not the same as parent B. Unlike C. metapsilosis AB isolates, the C. metapsilosis AC isolate has not undergone introgression at the mating type-like locus. In addition, the A and C haplotypes are not fully collinear. The C. metapsilosis AC isolate has undergone loss of heterozygosity with a preference for haplotype A, indicating that this isolate is in the early stages of genome stabilization.

U2 - 10.1093/g3journal/jkab367

DO - 10.1093/g3journal/jkab367

M3 - SCORING: Journal article

C2 - 34791169

VL - 12

JO - G3-GENES GENOM GENET

JF - G3-GENES GENOM GENET

SN - 2160-1836

IS - 1

M1 - jkab367

ER -