PortalPublikationenHypovitaminosis-D and EBV

Hypovitaminosis-D and EBV

Standard

Hypovitaminosis-D and EBV : no interdependence between two MS risk factors in a healthy young UK autumn cohort. / Ramien, Caren; Pachnio, Annette; Sisay, Sofia; Begum, Jusnara; Leese, Alison; Disanto, Giulio; Kuhle, Jens; Giovannoni, Gavin; Rickinson, Alan; Ramagopalan, Sreeram V; Moss, Paul; Meier, Ute-Christiane.

in: MULT SCLER J, Jahrgang 20, Nr. 6, 05.2014, S. 751-3.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ramien, C, Pachnio, A, Sisay, S, Begum, J, Leese, A, Disanto, G, Kuhle, J, Giovannoni, G, Rickinson, A, Ramagopalan, SV, Moss, P & Meier, U-C 2014, 'Hypovitaminosis-D and EBV: no interdependence between two MS risk factors in a healthy young UK autumn cohort', MULT SCLER J, Jg. 20, Nr. 6, S. 751-3. https://doi.org/10.1177/1352458513509507

APA

Ramien, C., Pachnio, A., Sisay, S., Begum, J., Leese, A., Disanto, G., Kuhle, J., Giovannoni, G., Rickinson, A., Ramagopalan, S. V., Moss, P., & Meier, U-C. (2014). Hypovitaminosis-D and EBV: no interdependence between two MS risk factors in a healthy young UK autumn cohort. MULT SCLER J, 20(6), 751-3. https://doi.org/10.1177/1352458513509507

Vancouver

Ramien C, Pachnio A, Sisay S, Begum J, Leese A, Disanto G et al. Hypovitaminosis-D and EBV: no interdependence between two MS risk factors in a healthy young UK autumn cohort. MULT SCLER J. 2014 Mai;20(6):751-3. https://doi.org/10.1177/1352458513509507

Bibtex

@article{b6861108ce8d412b8d6c2596c1a2ee5c,
title = "Hypovitaminosis-D and EBV: no interdependence between two MS risk factors in a healthy young UK autumn cohort",
abstract = "Late Epstein-Barr virus infection and hypovitaminosis-D as environmental risk factors in the pathogenesis of multiple sclerosis are gaining great interest. We, therefore, tested for in-vivo interdependence between Epstein-Barr-virus (EBV)-status and 25-hydroxyvitamin D3 (25(OH)D3) -level in healthy young individuals from a United Kingdom (UK) autumn cohort. EBV-load was measured by quantitative polymerase chain reaction and 25(OH)D3 levels by isotope-dilution liquid chromatography-tandem mass spectrometry. This young, healthy UK autumn cohort showed surprisingly low levels of 25(OH)D3 (mean value: 40.5 nmol/L ± 5.02). Furthermore, we found that low 25(OH)D3 levels did not impact on EBV load and anti-EBV nuclear antigen-1 (EBNA-1) titers. However, we observed a correlation between EBV load and EBNA-1 titers. These observations should be of value in the study of the potential relationship between hypovitaminosis-D and EBV-status in the pathophysiology of multiple sclerosis. ",
keywords = "Adult, Antibodies, Viral/analysis, Avitaminosis/immunology, Cohort Studies, Epstein-Barr Virus Infections/immunology, Epstein-Barr Virus Nuclear Antigens/metabolism, Herpesvirus 4, Human/immunology, Humans, Multiple Sclerosis/immunology, Risk Factors, Seasons, United Kingdom, Vitamin D/metabolism, Young Adult",
author = "Caren Ramien and Annette Pachnio and Sofia Sisay and Jusnara Begum and Alison Leese and Giulio Disanto and Jens Kuhle and Gavin Giovannoni and Alan Rickinson and Ramagopalan, {Sreeram V} and Paul Moss and Ute-Christiane Meier",
year = "2014",
month = may,
doi = "10.1177/1352458513509507",
language = "English",
volume = "20",
pages = "751--3",
journal = "MULT SCLER J",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Hypovitaminosis-D and EBV

T2 - no interdependence between two MS risk factors in a healthy young UK autumn cohort

AU - Ramien, Caren

AU - Pachnio, Annette

AU - Sisay, Sofia

AU - Begum, Jusnara

AU - Leese, Alison

AU - Disanto, Giulio

AU - Kuhle, Jens

AU - Giovannoni, Gavin

AU - Rickinson, Alan

AU - Ramagopalan, Sreeram V

AU - Moss, Paul

AU - Meier, Ute-Christiane

PY - 2014/5

Y1 - 2014/5

N2 - Late Epstein-Barr virus infection and hypovitaminosis-D as environmental risk factors in the pathogenesis of multiple sclerosis are gaining great interest. We, therefore, tested for in-vivo interdependence between Epstein-Barr-virus (EBV)-status and 25-hydroxyvitamin D3 (25(OH)D3) -level in healthy young individuals from a United Kingdom (UK) autumn cohort. EBV-load was measured by quantitative polymerase chain reaction and 25(OH)D3 levels by isotope-dilution liquid chromatography-tandem mass spectrometry. This young, healthy UK autumn cohort showed surprisingly low levels of 25(OH)D3 (mean value: 40.5 nmol/L ± 5.02). Furthermore, we found that low 25(OH)D3 levels did not impact on EBV load and anti-EBV nuclear antigen-1 (EBNA-1) titers. However, we observed a correlation between EBV load and EBNA-1 titers. These observations should be of value in the study of the potential relationship between hypovitaminosis-D and EBV-status in the pathophysiology of multiple sclerosis.

AB - Late Epstein-Barr virus infection and hypovitaminosis-D as environmental risk factors in the pathogenesis of multiple sclerosis are gaining great interest. We, therefore, tested for in-vivo interdependence between Epstein-Barr-virus (EBV)-status and 25-hydroxyvitamin D3 (25(OH)D3) -level in healthy young individuals from a United Kingdom (UK) autumn cohort. EBV-load was measured by quantitative polymerase chain reaction and 25(OH)D3 levels by isotope-dilution liquid chromatography-tandem mass spectrometry. This young, healthy UK autumn cohort showed surprisingly low levels of 25(OH)D3 (mean value: 40.5 nmol/L ± 5.02). Furthermore, we found that low 25(OH)D3 levels did not impact on EBV load and anti-EBV nuclear antigen-1 (EBNA-1) titers. However, we observed a correlation between EBV load and EBNA-1 titers. These observations should be of value in the study of the potential relationship between hypovitaminosis-D and EBV-status in the pathophysiology of multiple sclerosis.

KW - Adult

KW - Antibodies, Viral/analysis

KW - Avitaminosis/immunology

KW - Cohort Studies

KW - Epstein-Barr Virus Infections/immunology

KW - Epstein-Barr Virus Nuclear Antigens/metabolism

KW - Herpesvirus 4, Human/immunology

KW - Humans

KW - Multiple Sclerosis/immunology

KW - Risk Factors

KW - Seasons

KW - United Kingdom

KW - Vitamin D/metabolism

KW - Young Adult

U2 - 10.1177/1352458513509507

DO - 10.1177/1352458513509507

M3 - SCORING: Journal article

C2 - 24192216

VL - 20

SP - 751

EP - 753

JO - MULT SCLER J

JF - MULT SCLER J

SN - 1352-4585

IS - 6

ER -