Hypothalamic-Pituitary-Adrenocortical Axis Activity in Alcohol-Dependent Patients During Treatment with High-Dose Baclofen
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Hypothalamic-Pituitary-Adrenocortical Axis Activity in Alcohol-Dependent Patients During Treatment with High-Dose Baclofen. / Geisel, Olga; Schlemm, Ludwig; Hellweg, Rainer; Wiedemann, Klaus; Müller, Christian A.
in: PHARMACOPSYCHIATRY, Jahrgang 52, Nr. 1, 01.2019, S. 32-37.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Hypothalamic-Pituitary-Adrenocortical Axis Activity in Alcohol-Dependent Patients During Treatment with High-Dose Baclofen
AU - Geisel, Olga
AU - Schlemm, Ludwig
AU - Hellweg, Rainer
AU - Wiedemann, Klaus
AU - Müller, Christian A
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2019/1
Y1 - 2019/1
N2 - AIMS: Activity of the hypothalamic-pituitary-adrenocortical (HPA) axis has been reported to be affected in alcohol use disorder (AUD). It has been suggested that pharmacological relapse prevention in AUD might exert its effects partly by modulation of HPA axis activity. Here, we assessed the effects of high-dose treatment with baclofen on HPA axis activity in alcohol-dependent patients within a 24-week randomized, placebo-controlled trial (BACLAD study).METHODS: Plasma levels of copeptin, adrenocorticotropic hormone (ACTH), and cortisol were measured at 3 timepoints in alcohol-dependent patients during the study. Corresponding plasma levels in healthy controls were assessed once.RESULTS: ACTH blood levels were significantly higher in the group of alcohol-dependent patients compared to controls. In patients receiving individually titrated high-dose baclofen, plasma cortisol levels decreased significantly, whereas no significant alterations were found in the placebo group.CONCLUSIONS: Our study underlines again the role of HPA axis alterations in AUD. Furthermore, a decrease in hormonal stress levels during treatment with high-dose baclofen might contribute to the relapse preventive effects of this compound.
AB - AIMS: Activity of the hypothalamic-pituitary-adrenocortical (HPA) axis has been reported to be affected in alcohol use disorder (AUD). It has been suggested that pharmacological relapse prevention in AUD might exert its effects partly by modulation of HPA axis activity. Here, we assessed the effects of high-dose treatment with baclofen on HPA axis activity in alcohol-dependent patients within a 24-week randomized, placebo-controlled trial (BACLAD study).METHODS: Plasma levels of copeptin, adrenocorticotropic hormone (ACTH), and cortisol were measured at 3 timepoints in alcohol-dependent patients during the study. Corresponding plasma levels in healthy controls were assessed once.RESULTS: ACTH blood levels were significantly higher in the group of alcohol-dependent patients compared to controls. In patients receiving individually titrated high-dose baclofen, plasma cortisol levels decreased significantly, whereas no significant alterations were found in the placebo group.CONCLUSIONS: Our study underlines again the role of HPA axis alterations in AUD. Furthermore, a decrease in hormonal stress levels during treatment with high-dose baclofen might contribute to the relapse preventive effects of this compound.
KW - Journal Article
KW - Pituitary-Adrenal System/drug effects
KW - Double-Blind Method
KW - Humans
KW - Middle Aged
KW - Male
KW - Alcoholism/blood
KW - Hydrocortisone/blood
KW - Baclofen/pharmacology
KW - Young Adult
KW - Glycopeptides/blood
KW - Hypothalamo-Hypophyseal System/drug effects
KW - Adolescent
KW - Adult
KW - Female
KW - Aged
KW - Adrenocorticotropic Hormone/blood
U2 - 10.1055/s-0043-124189
DO - 10.1055/s-0043-124189
M3 - SCORING: Journal article
C2 - 29359279
VL - 52
SP - 32
EP - 37
JO - PHARMACOPSYCHIATRY
JF - PHARMACOPSYCHIATRY
SN - 0176-3679
IS - 1
ER -
