Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation

Ivayla Apostolova; Catharina Lange; Anja Mäurer; Per Suppa; Lothar Spies; Michel J Grothe; Till Nierhaus; Jochen B Fiebach; Elisabeth Steinhagen-Thiessen; R Buchert; Alzheimer’s Disease Neuroimaging Initiative

doi:10.1016/j.neurobiolaging.2018.01.002

Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation

Standard

Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation. / Apostolova, Ivayla; Lange, Catharina; Mäurer, Anja; Suppa, Per; Spies, Lothar; Grothe, Michel J; Nierhaus, Till; Fiebach, Jochen B; Steinhagen-Thiessen, Elisabeth; Buchert, R; Alzheimer’s Disease Neuroimaging Initiative.

in: NEUROBIOL AGING, Jahrgang 65, 05.2018, S. 41-50.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Apostolova, I, Lange, C, Mäurer, A, Suppa, P, Spies, L, Grothe, MJ, Nierhaus, T, Fiebach, JB, Steinhagen-Thiessen, E, Buchert, R & Alzheimer’s Disease Neuroimaging Initiative 2018, 'Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation', NEUROBIOL AGING, Jg. 65, S. 41-50. https://doi.org/10.1016/j.neurobiolaging.2018.01.002

APA

Apostolova, I., Lange, C., Mäurer, A., Suppa, P., Spies, L., Grothe, M. J., Nierhaus, T., Fiebach, J. B., Steinhagen-Thiessen, E., Buchert, R., & Alzheimer’s Disease Neuroimaging Initiative (2018). Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation. NEUROBIOL AGING, 65, 41-50. https://doi.org/10.1016/j.neurobiolaging.2018.01.002

Vancouver

Apostolova I, Lange C, Mäurer A, Suppa P, Spies L, Grothe MJ et al. Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation. NEUROBIOL AGING. 2018 Mai;65:41-50. https://doi.org/10.1016/j.neurobiolaging.2018.01.002

Bibtex

@article{8737a8f6b0734ac3860c9f94e0c7e612,

title = "Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation",

abstract = "Structural deterioration and volume loss of the hippocampal formation is observed in many diseases associated with memory decline. Paradoxically, glucose metabolism of the hippocampal formation can be increased at the same time. This might be a consequence of compensatory (beneficial) or maladaptive (detrimental) mechanisms. Aim of this study was to differentiate between compensation and maladaptation by analyzing the association between glucose metabolism in the hippocampal formation measured by positron emission tomography with the glucose analogue 18F-fluorodeoxyglucose and cognitive performance as characterized by the extended Consortium to Establish a Registry for Alzheimer's Disease test battery in a sample of 87 patients (81.8 ± 5.4 years) with mild cognitive impairment or mild dementia and varying etiological diagnoses. Glucose metabolism in the hippocampal formation was negatively correlated with the performance in several cognitive subdomains, most pronounced for verbal semantic fluency, independent of overall neuronal dysfunction, presence of clinical Alzheimer's disease, and overall cognitive performance. This finding provides evidence that increased glucose metabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation rather than a beneficial compensatory reaction. Excess glucose metabolism in the hippocampal formation might be a useful therapeutic target in these patients.",

keywords = "Journal Article",

author = "Ivayla Apostolova and Catharina Lange and Anja M{\"a}urer and Per Suppa and Lothar Spies and Grothe, {Michel J} and Till Nierhaus and Fiebach, {Jochen B} and Elisabeth Steinhagen-Thiessen and R Buchert and {Alzheimer{\textquoteright}s Disease Neuroimaging Initiative}",

year = "2018",

month = may,

doi = "10.1016/j.neurobiolaging.2018.01.002",

language = "English",

volume = "65",

pages = "41--50",

journal = "NEUROBIOL AGING",

issn = "0197-4580",

publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Hypermetabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation

AU - Apostolova, Ivayla

AU - Lange, Catharina

AU - Mäurer, Anja

AU - Suppa, Per

AU - Spies, Lothar

AU - Grothe, Michel J

AU - Nierhaus, Till

AU - Fiebach, Jochen B

AU - Steinhagen-Thiessen, Elisabeth

AU - Buchert, R

AU - Alzheimer’s Disease Neuroimaging Initiative

PY - 2018/5

Y1 - 2018/5

N2 - Structural deterioration and volume loss of the hippocampal formation is observed in many diseases associated with memory decline. Paradoxically, glucose metabolism of the hippocampal formation can be increased at the same time. This might be a consequence of compensatory (beneficial) or maladaptive (detrimental) mechanisms. Aim of this study was to differentiate between compensation and maladaptation by analyzing the association between glucose metabolism in the hippocampal formation measured by positron emission tomography with the glucose analogue 18F-fluorodeoxyglucose and cognitive performance as characterized by the extended Consortium to Establish a Registry for Alzheimer's Disease test battery in a sample of 87 patients (81.8 ± 5.4 years) with mild cognitive impairment or mild dementia and varying etiological diagnoses. Glucose metabolism in the hippocampal formation was negatively correlated with the performance in several cognitive subdomains, most pronounced for verbal semantic fluency, independent of overall neuronal dysfunction, presence of clinical Alzheimer's disease, and overall cognitive performance. This finding provides evidence that increased glucose metabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation rather than a beneficial compensatory reaction. Excess glucose metabolism in the hippocampal formation might be a useful therapeutic target in these patients.

AB - Structural deterioration and volume loss of the hippocampal formation is observed in many diseases associated with memory decline. Paradoxically, glucose metabolism of the hippocampal formation can be increased at the same time. This might be a consequence of compensatory (beneficial) or maladaptive (detrimental) mechanisms. Aim of this study was to differentiate between compensation and maladaptation by analyzing the association between glucose metabolism in the hippocampal formation measured by positron emission tomography with the glucose analogue 18F-fluorodeoxyglucose and cognitive performance as characterized by the extended Consortium to Establish a Registry for Alzheimer's Disease test battery in a sample of 87 patients (81.8 ± 5.4 years) with mild cognitive impairment or mild dementia and varying etiological diagnoses. Glucose metabolism in the hippocampal formation was negatively correlated with the performance in several cognitive subdomains, most pronounced for verbal semantic fluency, independent of overall neuronal dysfunction, presence of clinical Alzheimer's disease, and overall cognitive performance. This finding provides evidence that increased glucose metabolism in the hippocampal formation of cognitively impaired patients indicates detrimental maladaptation rather than a beneficial compensatory reaction. Excess glucose metabolism in the hippocampal formation might be a useful therapeutic target in these patients.

KW - Journal Article

U2 - 10.1016/j.neurobiolaging.2018.01.002

DO - 10.1016/j.neurobiolaging.2018.01.002

M3 - SCORING: Journal article

C2 - 29407465

VL - 65

SP - 41

EP - 50

JO - NEUROBIOL AGING

JF - NEUROBIOL AGING

SN - 0197-4580

ER -