Hyperdynamic circulation in liver cirrhosis
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Hyperdynamic circulation in liver cirrhosis : desensitization of vasoconstrictive receptors by G protein-coupled receptor kinases. / Vashist, Yogesh; Semela, David; Dufour, Jean-François.
in: MED HYPOTHESES, Jahrgang 62, Nr. 1, 2004, S. 82-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Hyperdynamic circulation in liver cirrhosis
T2 - desensitization of vasoconstrictive receptors by G protein-coupled receptor kinases
AU - Vashist, Yogesh
AU - Semela, David
AU - Dufour, Jean-François
PY - 2004
Y1 - 2004
N2 - Liver cirrhosis is complicated by a hyperdynamic circulation characterized by a generalized arterial vasodilatation. This vasodilatation occurs despite high plasma concentration of several potent vasoconstrictive substances like angiotensin, vasopressin, endothelin and norepinephrine. The experimental evidence available shows that compensatory adrenergic and vasoconstrictive signals are not normally transmitted intracellularly. G protein-coupled receptor kinases phosporylate plasma membrane receptors and block the transmission of the signal intracellularly. We hypothesize that these kinases are responsible for the desensitization to vasoconstrictors observed in patients with liver cirrhosis. Pharmacological intervention at this level might be beneficial to treat complications like ascites and variceal bleeding.
AB - Liver cirrhosis is complicated by a hyperdynamic circulation characterized by a generalized arterial vasodilatation. This vasodilatation occurs despite high plasma concentration of several potent vasoconstrictive substances like angiotensin, vasopressin, endothelin and norepinephrine. The experimental evidence available shows that compensatory adrenergic and vasoconstrictive signals are not normally transmitted intracellularly. G protein-coupled receptor kinases phosporylate plasma membrane receptors and block the transmission of the signal intracellularly. We hypothesize that these kinases are responsible for the desensitization to vasoconstrictors observed in patients with liver cirrhosis. Pharmacological intervention at this level might be beneficial to treat complications like ascites and variceal bleeding.
KW - Animals
KW - Humans
KW - Hypertension, Portal
KW - Liver
KW - Liver Cirrhosis
KW - Models, Biological
KW - Pressoreceptors
KW - Protein-Serine-Threonine Kinases
KW - Receptors, G-Protein-Coupled
KW - Splanchnic Circulation
KW - Vasoconstriction
M3 - SCORING: Journal article
C2 - 14729009
VL - 62
SP - 82
EP - 85
JO - MED HYPOTHESES
JF - MED HYPOTHESES
SN - 0306-9877
IS - 1
ER -