Hyaluronan in intra-operative edema of NF1-associated neurofibromas.
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Hyaluronan in intra-operative edema of NF1-associated neurofibromas. / Hagel, Christian; Behrens, Timo; Prehm, Peter; Schnabel, Claudia; Glatzel, Markus; Friedrich, Reinhard.
in: NEUROPATHOLOGY, Jahrgang 32, Nr. 4, 4, 2012, S. 406-414.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Hyaluronan in intra-operative edema of NF1-associated neurofibromas.
AU - Hagel, Christian
AU - Behrens, Timo
AU - Prehm, Peter
AU - Schnabel, Claudia
AU - Glatzel, Markus
AU - Friedrich, Reinhard
PY - 2012
Y1 - 2012
N2 - The tumor suppressor disorder neurofibromatosis type 1 (NF1) is associated with development of multiple neurofibromas which may grow intraneurally as plexiform neurofibromas (PNF) or intracutaneously (CNF). Upon surgery neurofibromas may show prominent swelling hindering skin-edge approximation. To assess whether the water binding glycosaminoglycan hyaluronan is involved in intra-operative swelling, 51 neurofibromas from 33 NF1-patients were investigated. Hyaluronan was histologically demonstrated and was quantified by ELISA. Molecular weight of hyaluronan was determined by gel filtration. Further, hyaluronan content was measured in cultivated Schwann cells and fibroblasts. Clinically, 67% of PNF were associated with moderate or severe intra-operative swelling, whereas only 36% of CNF showed this feature. Significantly higher levels of hyaluronan content were found in PNF compared to CNF (P?
AB - The tumor suppressor disorder neurofibromatosis type 1 (NF1) is associated with development of multiple neurofibromas which may grow intraneurally as plexiform neurofibromas (PNF) or intracutaneously (CNF). Upon surgery neurofibromas may show prominent swelling hindering skin-edge approximation. To assess whether the water binding glycosaminoglycan hyaluronan is involved in intra-operative swelling, 51 neurofibromas from 33 NF1-patients were investigated. Hyaluronan was histologically demonstrated and was quantified by ELISA. Molecular weight of hyaluronan was determined by gel filtration. Further, hyaluronan content was measured in cultivated Schwann cells and fibroblasts. Clinically, 67% of PNF were associated with moderate or severe intra-operative swelling, whereas only 36% of CNF showed this feature. Significantly higher levels of hyaluronan content were found in PNF compared to CNF (P?
M3 - SCORING: Journal article
VL - 32
SP - 406
EP - 414
JO - NEUROPATHOLOGY
JF - NEUROPATHOLOGY
SN - 0919-6544
IS - 4
M1 - 4
ER -
