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Humanized mouse models for organ-specific autoimmune diseases.

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Humanized mouse models for organ-specific autoimmune diseases. / Friese, Manuel A.; Jensen, Lise T; Willcox, Nick; Fugger, Lars.

in: CURR OPIN IMMUNOL, Jahrgang 18, Nr. 6, 6, 2006, S. 704-709.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Friese, MA, Jensen, LT, Willcox, N & Fugger, L 2006, 'Humanized mouse models for organ-specific autoimmune diseases.', CURR OPIN IMMUNOL, Jg. 18, Nr. 6, 6, S. 704-709. <http://www.ncbi.nlm.nih.gov/pubmed/17008081?dopt=Citation>

APA

Friese, M. A., Jensen, L. T., Willcox, N., & Fugger, L. (2006). Humanized mouse models for organ-specific autoimmune diseases. CURR OPIN IMMUNOL, 18(6), 704-709. [6]. http://www.ncbi.nlm.nih.gov/pubmed/17008081?dopt=Citation

Vancouver

Friese MA, Jensen LT, Willcox N, Fugger L. Humanized mouse models for organ-specific autoimmune diseases. CURR OPIN IMMUNOL. 2006;18(6):704-709. 6.

Bibtex

@article{444be6cb48294137ae48142b7145ee64,
title = "Humanized mouse models for organ-specific autoimmune diseases.",
abstract = "Murine models for human autoimmune diseases are an essential tool for studying pathogenesis and for identifying new therapeutic targets. Mice are not the natural disease host, and conventional models have proved to be poor predictors of efficacy and safety in recent trials aiming to translate drug and biologic treatments to humans. Evidently, further steps towards recapitulating human diseases are urgently needed, for example using transgenic predisposing human HLA allele(s) plus T-cell receptor(s) implicated in a representative patient's autoimmune disease. The latest development - humanizing most of the immune system by transplanting human hematopoietic stem cells into severely immunodeficient mice - should lead to even better modeling.",
author = "Friese, {Manuel A.} and Jensen, {Lise T} and Nick Willcox and Lars Fugger",
year = "2006",
language = "Deutsch",
volume = "18",
pages = "704--709",
number = "6",

}

RIS

TY - JOUR

T1 - Humanized mouse models for organ-specific autoimmune diseases.

AU - Friese, Manuel A.

AU - Jensen, Lise T

AU - Willcox, Nick

AU - Fugger, Lars

PY - 2006

Y1 - 2006

N2 - Murine models for human autoimmune diseases are an essential tool for studying pathogenesis and for identifying new therapeutic targets. Mice are not the natural disease host, and conventional models have proved to be poor predictors of efficacy and safety in recent trials aiming to translate drug and biologic treatments to humans. Evidently, further steps towards recapitulating human diseases are urgently needed, for example using transgenic predisposing human HLA allele(s) plus T-cell receptor(s) implicated in a representative patient's autoimmune disease. The latest development - humanizing most of the immune system by transplanting human hematopoietic stem cells into severely immunodeficient mice - should lead to even better modeling.

AB - Murine models for human autoimmune diseases are an essential tool for studying pathogenesis and for identifying new therapeutic targets. Mice are not the natural disease host, and conventional models have proved to be poor predictors of efficacy and safety in recent trials aiming to translate drug and biologic treatments to humans. Evidently, further steps towards recapitulating human diseases are urgently needed, for example using transgenic predisposing human HLA allele(s) plus T-cell receptor(s) implicated in a representative patient's autoimmune disease. The latest development - humanizing most of the immune system by transplanting human hematopoietic stem cells into severely immunodeficient mice - should lead to even better modeling.

M3 - SCORING: Zeitschriftenaufsatz

VL - 18

SP - 704

EP - 709

IS - 6

M1 - 6

ER -