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Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis.

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Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis. / Palioura, Sotiria; Herkel, Johannes; Simonovi, Miljan; Lohse, Ansgar W.; Söll, Dieter.

in: BIOL CHEM, Jahrgang 391, Nr. 7, 7, 2010, S. 771-776.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Palioura, S, Herkel, J, Simonovi, M, Lohse, AW & Söll, D 2010, 'Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis.', BIOL CHEM, Jg. 391, Nr. 7, 7, S. 771-776. <http://www.ncbi.nlm.nih.gov/pubmed/20623998?dopt=Citation>

APA

Palioura, S., Herkel, J., Simonovi, M., Lohse, A. W., & Söll, D. (2010). Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis. BIOL CHEM, 391(7), 771-776. [7]. http://www.ncbi.nlm.nih.gov/pubmed/20623998?dopt=Citation

Vancouver

Palioura S, Herkel J, Simonovi M, Lohse AW, Söll D. Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis. BIOL CHEM. 2010;391(7):771-776. 7.

Bibtex

@article{336694db01354c6c8fc30e70e33adaae,
title = "Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis.",
abstract = "Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec). The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. Here we review the discovery of human SepSecS and the current understanding of the immunogenicity of SLA/LP in autoimmune hepatitis.",
author = "Sotiria Palioura and Johannes Herkel and Miljan Simonovi and Lohse, {Ansgar W.} and Dieter S{\"o}ll",
year = "2010",
language = "Deutsch",
volume = "391",
pages = "771--776",
journal = "BIOL CHEM",
issn = "1431-6730",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "7",

}

RIS

TY - JOUR

T1 - Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis.

AU - Palioura, Sotiria

AU - Herkel, Johannes

AU - Simonovi, Miljan

AU - Lohse, Ansgar W.

AU - Söll, Dieter

PY - 2010

Y1 - 2010

N2 - Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec). The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. Here we review the discovery of human SepSecS and the current understanding of the immunogenicity of SLA/LP in autoimmune hepatitis.

AB - Selenocysteine, the 21st genetically encoded amino acid, is the major form of the antioxidant trace element selenium in the human body. In eukaryotes and archaea its synthesis proceeds through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of selenocysteine formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec). The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis. Here we review the discovery of human SepSecS and the current understanding of the immunogenicity of SLA/LP in autoimmune hepatitis.

M3 - SCORING: Zeitschriftenaufsatz

VL - 391

SP - 771

EP - 776

JO - BIOL CHEM

JF - BIOL CHEM

SN - 1431-6730

IS - 7

M1 - 7

ER -