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Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences

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Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. / Kim, Chun; Gajendran, Nadesan; Mittrücker, Hans-Willi; Weiwad, Matthias; Song, Young-Hwa; Hurwitz, Robert; Wilmanns, Matthias; Fischer, Gunter; Kaufmann, Stefan H E.

in: P NATL ACAD SCI USA, Jahrgang 102, Nr. 13, 29.03.2005, S. 4830-5.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kim, C, Gajendran, N, Mittrücker, H-W, Weiwad, M, Song, Y-H, Hurwitz, R, Wilmanns, M, Fischer, G & Kaufmann, SHE 2005, 'Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences', P NATL ACAD SCI USA, Jg. 102, Nr. 13, S. 4830-5. https://doi.org/10.1073/pnas.0500508102

APA

Kim, C., Gajendran, N., Mittrücker, H-W., Weiwad, M., Song, Y-H., Hurwitz, R., Wilmanns, M., Fischer, G., & Kaufmann, S. H. E. (2005). Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. P NATL ACAD SCI USA, 102(13), 4830-5. https://doi.org/10.1073/pnas.0500508102

Vancouver

Kim C, Gajendran N, Mittrücker H-W, Weiwad M, Song Y-H, Hurwitz R et al. Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences. P NATL ACAD SCI USA. 2005 Mär 29;102(13):4830-5. https://doi.org/10.1073/pnas.0500508102

Bibtex

@article{cc23fc775d1b4825b3e06a5a7d4262f3,
title = "Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences",
abstract = "Anthrax caused by Bacillus anthracis represents a major bioterroristic threat. B. anthracis produces lethal toxin (LeTx), a combination of lethal factor (LF) and protective antigen that plays a major role in anthrax pathogenesis. We demonstrate that human neutrophil alpha-defensins are potent inhibitors of LF. The inhibition of LF by human neutrophil protein (HNP-1) was noncompetitive. HNP-1 inhibited cleavage of a mitogen-activated protein kinase kinase and restored impaired mitogen-activated protein kinase signaling in LeTx-treated macrophages. HNP-1 rescued murine macrophages from B. anthracis-induced cytotoxicity, and in vivo treatment with HNP-1-3 protected mice against the fatal consequences of LeTx.",
keywords = "Animals, Antigens, Bacterial, Bacterial Toxins, Female, Furin, Humans, Kinetics, MAP Kinase Kinase 3, Macrophages, Matrix Metalloproteinase Inhibitors, Mice, Mice, Inbred BALB C, Signal Transduction, Spores, Bacterial, Survival Analysis, Tetrazolium Salts, Thiazoles, alpha-Defensins",
author = "Chun Kim and Nadesan Gajendran and Hans-Willi Mittr{\"u}cker and Matthias Weiwad and Young-Hwa Song and Robert Hurwitz and Matthias Wilmanns and Gunter Fischer and Kaufmann, {Stefan H E}",
year = "2005",
month = mar,
day = "29",
doi = "10.1073/pnas.0500508102",
language = "English",
volume = "102",
pages = "4830--5",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "13",

}

RIS

TY - JOUR

T1 - Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences

AU - Kim, Chun

AU - Gajendran, Nadesan

AU - Mittrücker, Hans-Willi

AU - Weiwad, Matthias

AU - Song, Young-Hwa

AU - Hurwitz, Robert

AU - Wilmanns, Matthias

AU - Fischer, Gunter

AU - Kaufmann, Stefan H E

PY - 2005/3/29

Y1 - 2005/3/29

N2 - Anthrax caused by Bacillus anthracis represents a major bioterroristic threat. B. anthracis produces lethal toxin (LeTx), a combination of lethal factor (LF) and protective antigen that plays a major role in anthrax pathogenesis. We demonstrate that human neutrophil alpha-defensins are potent inhibitors of LF. The inhibition of LF by human neutrophil protein (HNP-1) was noncompetitive. HNP-1 inhibited cleavage of a mitogen-activated protein kinase kinase and restored impaired mitogen-activated protein kinase signaling in LeTx-treated macrophages. HNP-1 rescued murine macrophages from B. anthracis-induced cytotoxicity, and in vivo treatment with HNP-1-3 protected mice against the fatal consequences of LeTx.

AB - Anthrax caused by Bacillus anthracis represents a major bioterroristic threat. B. anthracis produces lethal toxin (LeTx), a combination of lethal factor (LF) and protective antigen that plays a major role in anthrax pathogenesis. We demonstrate that human neutrophil alpha-defensins are potent inhibitors of LF. The inhibition of LF by human neutrophil protein (HNP-1) was noncompetitive. HNP-1 inhibited cleavage of a mitogen-activated protein kinase kinase and restored impaired mitogen-activated protein kinase signaling in LeTx-treated macrophages. HNP-1 rescued murine macrophages from B. anthracis-induced cytotoxicity, and in vivo treatment with HNP-1-3 protected mice against the fatal consequences of LeTx.

KW - Animals

KW - Antigens, Bacterial

KW - Bacterial Toxins

KW - Female

KW - Furin

KW - Humans

KW - Kinetics

KW - MAP Kinase Kinase 3

KW - Macrophages

KW - Matrix Metalloproteinase Inhibitors

KW - Mice

KW - Mice, Inbred BALB C

KW - Signal Transduction

KW - Spores, Bacterial

KW - Survival Analysis

KW - Tetrazolium Salts

KW - Thiazoles

KW - alpha-Defensins

U2 - 10.1073/pnas.0500508102

DO - 10.1073/pnas.0500508102

M3 - SCORING: Journal article

C2 - 15772169

VL - 102

SP - 4830

EP - 4835

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 13

ER -