Human γδ TCR Repertoires in Health and Disease
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Human γδ TCR Repertoires in Health and Disease. / Fichtner, Alina Suzann; Ravens, Sarina; Prinz, Immo.
in: CELLS-BASEL, Jahrgang 9, Nr. 4, 800, 26.03.2020.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Human γδ TCR Repertoires in Health and Disease
AU - Fichtner, Alina Suzann
AU - Ravens, Sarina
AU - Prinz, Immo
PY - 2020/3/26
Y1 - 2020/3/26
N2 - The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ T cell receptor diversity builds on specific monoclonal antibodies that discriminate between the two major subsets, namely Vδ2+ and Vδ1+ T cells. Of those two subsets, Vδ2+ T cells seem to better fit into a role of innate T cells with semi-invariant TCR usage, as compared to an adaptive-like biology of some Vδ1+ subsets. Yet, this distinction into innate-like Vδ2+ and adaptive-like Vδ1+ γδ T cells does not quite recapitulate the full diversity of γδ T cell subsets, ligands and interaction modes. Here, we review how the recent introduction of high-throughput TCR repertoire sequencing has boosted our knowledge of γδ T cell repertoire diversity beyond Vδ2+ and Vδ1+ T cells. We discuss the current understanding of clonal composition and the dynamics of human γδ TCR repertoires in health and disease.
AB - The T cell receptor (TCR) repertoires of γδ T cells are very different to those of αβ T cells. While the theoretical TCR repertoire diversity of γδ T cells is estimated to exceed the diversity of αβ T cells by far, γδ T cells are still understood as more invariant T cells that only use a limited set of γδ TCRs. Most of our current knowledge of human γδ T cell receptor diversity builds on specific monoclonal antibodies that discriminate between the two major subsets, namely Vδ2+ and Vδ1+ T cells. Of those two subsets, Vδ2+ T cells seem to better fit into a role of innate T cells with semi-invariant TCR usage, as compared to an adaptive-like biology of some Vδ1+ subsets. Yet, this distinction into innate-like Vδ2+ and adaptive-like Vδ1+ γδ T cells does not quite recapitulate the full diversity of γδ T cell subsets, ligands and interaction modes. Here, we review how the recent introduction of high-throughput TCR repertoire sequencing has boosted our knowledge of γδ T cell repertoire diversity beyond Vδ2+ and Vδ1+ T cells. We discuss the current understanding of clonal composition and the dynamics of human γδ TCR repertoires in health and disease.
KW - Disease
KW - Embryonic Development
KW - Health
KW - Humans
KW - Infections/immunology
KW - Receptors, Antigen, T-Cell, gamma-delta/metabolism
KW - T-Lymphocyte Subsets/immunology
U2 - 10.3390/cells9040800
DO - 10.3390/cells9040800
M3 - SCORING: Review article
C2 - 32225004
VL - 9
JO - CELLS-BASEL
JF - CELLS-BASEL
SN - 2073-4409
IS - 4
M1 - 800
ER -