Hormone production in pituitary adenomas following external irradiation
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Hormone production in pituitary adenomas following external irradiation : an experimental study in rats. / Friedrich, R E; Saeger, W; Laas, R; Friedrich, S B.
in: ANTICANCER RES, Jahrgang 20, Nr. 6D, 2001, S. 5165-70.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Hormone production in pituitary adenomas following external irradiation
T2 - an experimental study in rats
AU - Friedrich, R E
AU - Saeger, W
AU - Laas, R
AU - Friedrich, S B
PY - 2001
Y1 - 2001
N2 - INTRODUCTION: The aim of this study was to investigate the hormone production in pituitary gland tumors following fractionated external irradiation in rats.MATERIALS AND METHODS: Sixty female Wistar rats 3 to 4 month of age at the beginning of the experiments, were subjected to fractionated roentgen-rays exposure, 2 Grays (Gy) daily, either up to 20, 40 or 60 Gy. The animals were sacrificed either 6 month or 1 year after completion of the randomly assigned irradiation protocol.RESULTS: We found 9 pituitary tumors in 60 irradiated rats (15%). All tumors proved to be adenomas. Immunohistochemical analysis of hormone production in remnants of the normal adenohypophysis revealed immunoreactivity for growth hormone (GH), adrenocorticotropic hormone (ACTH), prolactin (PRL), thyroid-stimulating hormone (TSH), and follicle-stimulating hormone (FSH). In adenomas, 4 cases were immunoreactive for TSH, 4 for GH, 2 for PRL, and 2 for FSH. The tumors were not reactive with anti-ACTH and anti-LH (luteinizing hormone).DISCUSSION: We concluded that irradiation accelerates the development of pituitary gland adenomas. In our series these tumors were predominantly incidental findings at necropsies after pre-termed follow-up, with a variety of hormone producing tumor cells. However, 4 of 9 tumors in our study were not producing hormones.
AB - INTRODUCTION: The aim of this study was to investigate the hormone production in pituitary gland tumors following fractionated external irradiation in rats.MATERIALS AND METHODS: Sixty female Wistar rats 3 to 4 month of age at the beginning of the experiments, were subjected to fractionated roentgen-rays exposure, 2 Grays (Gy) daily, either up to 20, 40 or 60 Gy. The animals were sacrificed either 6 month or 1 year after completion of the randomly assigned irradiation protocol.RESULTS: We found 9 pituitary tumors in 60 irradiated rats (15%). All tumors proved to be adenomas. Immunohistochemical analysis of hormone production in remnants of the normal adenohypophysis revealed immunoreactivity for growth hormone (GH), adrenocorticotropic hormone (ACTH), prolactin (PRL), thyroid-stimulating hormone (TSH), and follicle-stimulating hormone (FSH). In adenomas, 4 cases were immunoreactive for TSH, 4 for GH, 2 for PRL, and 2 for FSH. The tumors were not reactive with anti-ACTH and anti-LH (luteinizing hormone).DISCUSSION: We concluded that irradiation accelerates the development of pituitary gland adenomas. In our series these tumors were predominantly incidental findings at necropsies after pre-termed follow-up, with a variety of hormone producing tumor cells. However, 4 of 9 tumors in our study were not producing hormones.
KW - Animals
KW - Female
KW - Growth Hormone
KW - Pituitary Neoplasms
KW - Prolactin
KW - Prolactinoma
KW - Rats
KW - Rats, Wistar
KW - Thyrotropin
M3 - SCORING: Journal article
C2 - 11326689
VL - 20
SP - 5165
EP - 5170
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 6D
ER -