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Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke

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Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke. / Schwieren, Laura; Jensen, Märit; Schulz, Robert; Lezius, Susanne; Laxy, Elena; Milatz, Magalie; Thomalla, Götz; Böger, Rainer; Gerloff, Christian; Magnus, Tim; Schwedhelm, Edzard; Choe, Chi-Un.

in: LIFE-BASEL, Jahrgang 13, Nr. 7, 1590, 20.07.2023.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schwieren, L, Jensen, M, Schulz, R, Lezius, S, Laxy, E, Milatz, M, Thomalla, G, Böger, R, Gerloff, C, Magnus, T, Schwedhelm, E & Choe, C-U 2023, 'Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke', LIFE-BASEL, Jg. 13, Nr. 7, 1590. https://doi.org/10.3390/life13071590

APA

Schwieren, L., Jensen, M., Schulz, R., Lezius, S., Laxy, E., Milatz, M., Thomalla, G., Böger, R., Gerloff, C., Magnus, T., Schwedhelm, E., & Choe, C-U. (2023). Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke. LIFE-BASEL, 13(7), [1590]. https://doi.org/10.3390/life13071590

Vancouver

Schwieren L, Jensen M, Schulz R, Lezius S, Laxy E, Milatz M et al. Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke. LIFE-BASEL. 2023 Jul 20;13(7). 1590. https://doi.org/10.3390/life13071590

Bibtex

@article{067b5871541d447fb78ecbf669273ca4,
title = "Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke",
abstract = "Homoarginine is associated with cardio- and cerebrovascular morbidity and mortality. However, the underlying pathomechanisms remain elusive. Here, we evaluated the association of homoarginine with adverse events (i.e., death, stroke, and myocardial infarction) and carotid intima-media thickness (cIMT) in stroke patients. In the prospective bioMARKers in STROKE (MARK-STROKE) cohort, patients with acute ischemic stroke or transient ischemic attack (TIA) were enrolled. Plasma homoarginine concentrations were analyzed and associated with clinical phenotypes in cross-sectional (374 patients) and prospective (273 patients) analyses. Adjustments for possible confounders were evaluated. A two-fold increase in homoarginine was inversely associated with the National Institutes of Health Stroke Scale (NIHSS) score at admission, cIMT, and prevalent atrial fibrillation (mean factor -0.68 [95% confidence interval (CI): -1.30, -0.07], -0.14 [95% CI: -0.22, -0.05]; and odds ratio 0.57 [95% CI: 0.33, 0.96], respectively). During the follow-up (median 284 [25th, 75th percentile: 198, 431] days), individuals with homoarginine levels in the highest tertile had fewer incident events compared with patients in the lowest homoarginine tertile independent of traditional risk factors (hazard ratio 0.22 [95% CI: 0.08, 0.63]). A lower prevalence of atrial fibrillation and a reduced cIMT pinpointed potential underlying pathomechanisms.",
author = "Laura Schwieren and M{\"a}rit Jensen and Robert Schulz and Susanne Lezius and Elena Laxy and Magalie Milatz and G{\"o}tz Thomalla and Rainer B{\"o}ger and Christian Gerloff and Tim Magnus and Edzard Schwedhelm and Chi-Un Choe",
year = "2023",
month = jul,
day = "20",
doi = "10.3390/life13071590",
language = "English",
volume = "13",
journal = "LIFE-BASEL",
issn = "2075-1729",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "7",

}

RIS

TY - JOUR

T1 - Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke

AU - Schwieren, Laura

AU - Jensen, Märit

AU - Schulz, Robert

AU - Lezius, Susanne

AU - Laxy, Elena

AU - Milatz, Magalie

AU - Thomalla, Götz

AU - Böger, Rainer

AU - Gerloff, Christian

AU - Magnus, Tim

AU - Schwedhelm, Edzard

AU - Choe, Chi-Un

PY - 2023/7/20

Y1 - 2023/7/20

N2 - Homoarginine is associated with cardio- and cerebrovascular morbidity and mortality. However, the underlying pathomechanisms remain elusive. Here, we evaluated the association of homoarginine with adverse events (i.e., death, stroke, and myocardial infarction) and carotid intima-media thickness (cIMT) in stroke patients. In the prospective bioMARKers in STROKE (MARK-STROKE) cohort, patients with acute ischemic stroke or transient ischemic attack (TIA) were enrolled. Plasma homoarginine concentrations were analyzed and associated with clinical phenotypes in cross-sectional (374 patients) and prospective (273 patients) analyses. Adjustments for possible confounders were evaluated. A two-fold increase in homoarginine was inversely associated with the National Institutes of Health Stroke Scale (NIHSS) score at admission, cIMT, and prevalent atrial fibrillation (mean factor -0.68 [95% confidence interval (CI): -1.30, -0.07], -0.14 [95% CI: -0.22, -0.05]; and odds ratio 0.57 [95% CI: 0.33, 0.96], respectively). During the follow-up (median 284 [25th, 75th percentile: 198, 431] days), individuals with homoarginine levels in the highest tertile had fewer incident events compared with patients in the lowest homoarginine tertile independent of traditional risk factors (hazard ratio 0.22 [95% CI: 0.08, 0.63]). A lower prevalence of atrial fibrillation and a reduced cIMT pinpointed potential underlying pathomechanisms.

AB - Homoarginine is associated with cardio- and cerebrovascular morbidity and mortality. However, the underlying pathomechanisms remain elusive. Here, we evaluated the association of homoarginine with adverse events (i.e., death, stroke, and myocardial infarction) and carotid intima-media thickness (cIMT) in stroke patients. In the prospective bioMARKers in STROKE (MARK-STROKE) cohort, patients with acute ischemic stroke or transient ischemic attack (TIA) were enrolled. Plasma homoarginine concentrations were analyzed and associated with clinical phenotypes in cross-sectional (374 patients) and prospective (273 patients) analyses. Adjustments for possible confounders were evaluated. A two-fold increase in homoarginine was inversely associated with the National Institutes of Health Stroke Scale (NIHSS) score at admission, cIMT, and prevalent atrial fibrillation (mean factor -0.68 [95% confidence interval (CI): -1.30, -0.07], -0.14 [95% CI: -0.22, -0.05]; and odds ratio 0.57 [95% CI: 0.33, 0.96], respectively). During the follow-up (median 284 [25th, 75th percentile: 198, 431] days), individuals with homoarginine levels in the highest tertile had fewer incident events compared with patients in the lowest homoarginine tertile independent of traditional risk factors (hazard ratio 0.22 [95% CI: 0.08, 0.63]). A lower prevalence of atrial fibrillation and a reduced cIMT pinpointed potential underlying pathomechanisms.

U2 - 10.3390/life13071590

DO - 10.3390/life13071590

M3 - SCORING: Journal article

C2 - 37511965

VL - 13

JO - LIFE-BASEL

JF - LIFE-BASEL

SN - 2075-1729

IS - 7

M1 - 1590

ER -