HLA and alveolar echinococcosis.
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HLA and alveolar echinococcosis. / Eiermann, Thomas; Bettens, F; Tiberghien, P; Schmitz, K; Beurton, I; Bresson-Hadni, S; Ammann, R W; Goldmann, S F; Vuitton, D A; Gottstein, B; Kern, P.
in: TISSUE ANTIGENS, Jahrgang 52, Nr. 2, 2, 1998, S. 124-129.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - HLA and alveolar echinococcosis.
AU - Eiermann, Thomas
AU - Bettens, F
AU - Tiberghien, P
AU - Schmitz, K
AU - Beurton, I
AU - Bresson-Hadni, S
AU - Ammann, R W
AU - Goldmann, S F
AU - Vuitton, D A
AU - Gottstein, B
AU - Kern, P
PY - 1998
Y1 - 1998
N2 - Evidence in animal intermediate hosts that susceptibility to larval infection with Echinococcus multilocularis is restricted to individual host factors prompted us to investigate the susceptibility markers in humans. Because antigens of the extracellular parasite E. multilocularis are possibly presented by MHC molecules in a restricted way, we speculated that MHC polymorphism may influence resistance of the host towards infection and course of disease. We studied HLA-A, -B, -DRB1, -DQB1 and -DPB1 polymorphism in 151 patients with alveolar echinococcosis. Patients with an observation period of more than 2 years were grouped according to the clinical follow-up into cured (no recurrence following surgery) patients and patients with regressive or progressive forms of disease during benzimidazole chemotherapy. By comparing phenotypic frequency between patients with alveolar echinococcosis and healthy controls, HLA-DRB1*11 was associated with a reduced risk for disease development (odds ratio=0.55, 95% confidence interval=0.34-0.88; P=0.01). HLA-DQB1*02 was more frequent in patients with progressive disease when compared with patients with regressive disease (54.3% vs 28.3%, P=0.02). The result suggests that HLA-DRB1*11 might confer protection against alveolar echinococcosis and that HLA-DQB1*02 may indicate a risk for progressive disease development. The findings may facilitate the search for immunodominant T-cell epitopes of E. multilocularis.
AB - Evidence in animal intermediate hosts that susceptibility to larval infection with Echinococcus multilocularis is restricted to individual host factors prompted us to investigate the susceptibility markers in humans. Because antigens of the extracellular parasite E. multilocularis are possibly presented by MHC molecules in a restricted way, we speculated that MHC polymorphism may influence resistance of the host towards infection and course of disease. We studied HLA-A, -B, -DRB1, -DQB1 and -DPB1 polymorphism in 151 patients with alveolar echinococcosis. Patients with an observation period of more than 2 years were grouped according to the clinical follow-up into cured (no recurrence following surgery) patients and patients with regressive or progressive forms of disease during benzimidazole chemotherapy. By comparing phenotypic frequency between patients with alveolar echinococcosis and healthy controls, HLA-DRB1*11 was associated with a reduced risk for disease development (odds ratio=0.55, 95% confidence interval=0.34-0.88; P=0.01). HLA-DQB1*02 was more frequent in patients with progressive disease when compared with patients with regressive disease (54.3% vs 28.3%, P=0.02). The result suggests that HLA-DRB1*11 might confer protection against alveolar echinococcosis and that HLA-DQB1*02 may indicate a risk for progressive disease development. The findings may facilitate the search for immunodominant T-cell epitopes of E. multilocularis.
KW - Animals
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Polymorphism, Genetic
KW - Cohort Studies
KW - Phenotype
KW - Biological Markers
KW - Antigens, Helminth/immunology
KW - Echinococcosis/immunology
KW - Echinococcus
KW - HLA-DQ Antigens/genetics/immunology
KW - HLA-DQ beta-Chains
KW - HLA-DR Antigens/genetics/immunology
KW - HLA-DRB1 Chains
KW - Histocompatibility Antigens Class I/genetics/immunology
KW - Histocompatibility Antigens Class II/genetics/immunology
KW - Pulmonary Alveoli/immunology/parasitology
KW - Animals
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Polymorphism, Genetic
KW - Cohort Studies
KW - Phenotype
KW - Biological Markers
KW - Antigens, Helminth/immunology
KW - Echinococcosis/immunology
KW - Echinococcus
KW - HLA-DQ Antigens/genetics/immunology
KW - HLA-DQ beta-Chains
KW - HLA-DR Antigens/genetics/immunology
KW - HLA-DRB1 Chains
KW - Histocompatibility Antigens Class I/genetics/immunology
KW - Histocompatibility Antigens Class II/genetics/immunology
KW - Pulmonary Alveoli/immunology/parasitology
M3 - SCORING: Journal article
VL - 52
SP - 124
EP - 129
JO - TISSUE ANTIGENS
JF - TISSUE ANTIGENS
SN - 0001-2815
IS - 2
M1 - 2
ER -
