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HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis

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HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis. / Angin, Mathieu; Sharma, Siddhartha; King, Melanie; Murooka, Thomas T; Ghebremichael, Musie; Mempel, Thorsten R; Walker, Bruce D; Bhasin, Manoj K; Addo, Marylyn Martina.

in: J INFECT DIS, Jahrgang 210, Nr. 6, 15.09.2014, S. 899-903.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Angin, M, Sharma, S, King, M, Murooka, TT, Ghebremichael, M, Mempel, TR, Walker, BD, Bhasin, MK & Addo, MM 2014, 'HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis', J INFECT DIS, Jg. 210, Nr. 6, S. 899-903. https://doi.org/10.1093/infdis/jiu188

APA

Angin, M., Sharma, S., King, M., Murooka, T. T., Ghebremichael, M., Mempel, T. R., Walker, B. D., Bhasin, M. K., & Addo, M. M. (2014). HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis. J INFECT DIS, 210(6), 899-903. https://doi.org/10.1093/infdis/jiu188

Vancouver

Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR et al. HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis. J INFECT DIS. 2014 Sep 15;210(6):899-903. https://doi.org/10.1093/infdis/jiu188

Bibtex

@article{c20164a6356647b5a94152fb1b5d0aab,
title = "HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis",
abstract = "The impact of CD4+ regulatory T cells (Tregs) on human immunodeficiency virus type 1 (HIV-1) pathogenesis remains incompletely understood. Although it has been shown that Tregs can be infected with HIV-1, the consequences of infection on a per-cell basis are still unknown. In vitro HIV-GFP infected and noninfected Tregs were isolated by flow-based cell-sorting to investigate Treg suppressive capacity and gene expression profiles. Our data show that HIV-1-infected Tregs were significantly less suppressive than noninfected Tregs and demonstrated down-regulation of genes critical to Treg function. This impaired function may have detrimental consequences for the control of generalized immune activation and accelerate HIV disease progression.",
keywords = "Down-Regulation, Flow Cytometry, Gene Expression Profiling, HIV Infections, HIV-1, Humans, Immunity, Cellular, In Vitro Techniques, T-Lymphocytes, Regulatory",
author = "Mathieu Angin and Siddhartha Sharma and Melanie King and Murooka, {Thomas T} and Musie Ghebremichael and Mempel, {Thorsten R} and Walker, {Bruce D} and Bhasin, {Manoj K} and Addo, {Marylyn Martina}",
note = "{\textcopyright} The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.",
year = "2014",
month = sep,
day = "15",
doi = "10.1093/infdis/jiu188",
language = "English",
volume = "210",
pages = "899--903",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis

AU - Angin, Mathieu

AU - Sharma, Siddhartha

AU - King, Melanie

AU - Murooka, Thomas T

AU - Ghebremichael, Musie

AU - Mempel, Thorsten R

AU - Walker, Bruce D

AU - Bhasin, Manoj K

AU - Addo, Marylyn Martina

N1 - © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

PY - 2014/9/15

Y1 - 2014/9/15

N2 - The impact of CD4+ regulatory T cells (Tregs) on human immunodeficiency virus type 1 (HIV-1) pathogenesis remains incompletely understood. Although it has been shown that Tregs can be infected with HIV-1, the consequences of infection on a per-cell basis are still unknown. In vitro HIV-GFP infected and noninfected Tregs were isolated by flow-based cell-sorting to investigate Treg suppressive capacity and gene expression profiles. Our data show that HIV-1-infected Tregs were significantly less suppressive than noninfected Tregs and demonstrated down-regulation of genes critical to Treg function. This impaired function may have detrimental consequences for the control of generalized immune activation and accelerate HIV disease progression.

AB - The impact of CD4+ regulatory T cells (Tregs) on human immunodeficiency virus type 1 (HIV-1) pathogenesis remains incompletely understood. Although it has been shown that Tregs can be infected with HIV-1, the consequences of infection on a per-cell basis are still unknown. In vitro HIV-GFP infected and noninfected Tregs were isolated by flow-based cell-sorting to investigate Treg suppressive capacity and gene expression profiles. Our data show that HIV-1-infected Tregs were significantly less suppressive than noninfected Tregs and demonstrated down-regulation of genes critical to Treg function. This impaired function may have detrimental consequences for the control of generalized immune activation and accelerate HIV disease progression.

KW - Down-Regulation

KW - Flow Cytometry

KW - Gene Expression Profiling

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Immunity, Cellular

KW - In Vitro Techniques

KW - T-Lymphocytes, Regulatory

U2 - 10.1093/infdis/jiu188

DO - 10.1093/infdis/jiu188

M3 - SCORING: Journal article

C2 - 24664171

VL - 210

SP - 899

EP - 903

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 6

ER -