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HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells

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HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells. / Hong, Henoch S; Eberhard, Johanna M; Keudel, Phillip; Bollmann, Benjamin A; Ballmaier, Matthias; Bhatnagar, Nupur; Zielinska-Skowronek, Margot; Schmidt, Reinhold E; Meyer-Olson, Dirk.

in: J VIROL, Jahrgang 84, Nr. 2, 01.2010, S. 1183-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hong, HS, Eberhard, JM, Keudel, P, Bollmann, BA, Ballmaier, M, Bhatnagar, N, Zielinska-Skowronek, M, Schmidt, RE & Meyer-Olson, D 2010, 'HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells', J VIROL, Jg. 84, Nr. 2, S. 1183-8. https://doi.org/10.1128/JVI.01675-09

APA

Hong, H. S., Eberhard, J. M., Keudel, P., Bollmann, B. A., Ballmaier, M., Bhatnagar, N., Zielinska-Skowronek, M., Schmidt, R. E., & Meyer-Olson, D. (2010). HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells. J VIROL, 84(2), 1183-8. https://doi.org/10.1128/JVI.01675-09

Vancouver

Hong HS, Eberhard JM, Keudel P, Bollmann BA, Ballmaier M, Bhatnagar N et al. HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells. J VIROL. 2010 Jan;84(2):1183-8. https://doi.org/10.1128/JVI.01675-09

Bibtex

@article{a61234d0693b446c92f12bc2870c14e5,
title = "HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells",
abstract = "HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(-) and CD57(dim) cells but not of CD57(bright) cells on CD56(dim) CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR(+), Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.",
keywords = "CD56 Antigen/metabolism, CD57 Antigens/metabolism, Cell Differentiation, HIV Infections/immunology, HIV-1/immunology, Humans, Killer Cells, Natural/cytology, Receptors, IgG/metabolism",
author = "Hong, {Henoch S} and Eberhard, {Johanna M} and Phillip Keudel and Bollmann, {Benjamin A} and Matthias Ballmaier and Nupur Bhatnagar and Margot Zielinska-Skowronek and Schmidt, {Reinhold E} and Dirk Meyer-Olson",
year = "2010",
month = jan,
doi = "10.1128/JVI.01675-09",
language = "English",
volume = "84",
pages = "1183--8",
journal = "J VIROL",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "2",

}

RIS

TY - JOUR

T1 - HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells

AU - Hong, Henoch S

AU - Eberhard, Johanna M

AU - Keudel, Phillip

AU - Bollmann, Benjamin A

AU - Ballmaier, Matthias

AU - Bhatnagar, Nupur

AU - Zielinska-Skowronek, Margot

AU - Schmidt, Reinhold E

AU - Meyer-Olson, Dirk

PY - 2010/1

Y1 - 2010/1

N2 - HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(-) and CD57(dim) cells but not of CD57(bright) cells on CD56(dim) CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR(+), Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.

AB - HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(-) and CD57(dim) cells but not of CD57(bright) cells on CD56(dim) CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR(+), Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.

KW - CD56 Antigen/metabolism

KW - CD57 Antigens/metabolism

KW - Cell Differentiation

KW - HIV Infections/immunology

KW - HIV-1/immunology

KW - Humans

KW - Killer Cells, Natural/cytology

KW - Receptors, IgG/metabolism

U2 - 10.1128/JVI.01675-09

DO - 10.1128/JVI.01675-09

M3 - SCORING: Journal article

C2 - 19906929

VL - 84

SP - 1183

EP - 1188

JO - J VIROL

JF - J VIROL

SN - 0022-538X

IS - 2

ER -