Histoscanning has low sensitivity and specificity for seminal vesicle invasion

Jonas Schiffmann; Burkhard Beyer; Johannes Fischer; Pierre Tennstedt; Katharina Boehm; Uwe Michl; Markus Graefen; Georg Salomon

doi:10.1016/j.urology.2014.06.050

Histoscanning has low sensitivity and specificity for seminal vesicle invasion

Standard

Histoscanning has low sensitivity and specificity for seminal vesicle invasion. / Schiffmann, Jonas; Beyer, Burkhard; Fischer, Johannes; Tennstedt, Pierre; Boehm, Katharina; Michl, Uwe; Graefen, Markus; Salomon, Georg.

in: UROLOGY, Jahrgang 84, Nr. 5, 01.11.2014, S. 1168-71.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schiffmann, J, Beyer, B, Fischer, J, Tennstedt, P, Boehm, K, Michl, U, Graefen, M & Salomon, G 2014, 'Histoscanning has low sensitivity and specificity for seminal vesicle invasion', UROLOGY, Jg. 84, Nr. 5, S. 1168-71. https://doi.org/10.1016/j.urology.2014.06.050

APA

Schiffmann, J., Beyer, B., Fischer, J., Tennstedt, P., Boehm, K., Michl, U., Graefen, M., & Salomon, G. (2014). Histoscanning has low sensitivity and specificity for seminal vesicle invasion. UROLOGY, 84(5), 1168-71. https://doi.org/10.1016/j.urology.2014.06.050

Vancouver

Schiffmann J, Beyer B, Fischer J, Tennstedt P, Boehm K, Michl U et al. Histoscanning has low sensitivity and specificity for seminal vesicle invasion. UROLOGY. 2014 Nov 1;84(5):1168-71. https://doi.org/10.1016/j.urology.2014.06.050

Bibtex

@article{2b83ccbb51b846c88315d80b359301d4,

title = "Histoscanning has low sensitivity and specificity for seminal vesicle invasion",

abstract = "OBJECTIVE: To examine the accuracy of HistoScanning (HS) in detecting seminal vesicle (SV) invasion (SVI) within prostate cancer (PCa) patients.METHODS: We relied on our prospective institutional database. Patients who received HS before radical prostatectomy were included in the study cohort. An experienced HS examiner retrospectively reanalyzed the HS data blinded to patient characteristics and pathologic results. The HS results for every single SV were compared with the corresponding findings from the final pathologic report after radical prostatectomy. An area under the receiver operating characteristic curve for the prediction of SVI by HS was calculated. Depending on HS signal volume cut-offs (>0, >0.2, and >0.5 mL), the sensitivity, specificity, positive predictive value, and negative predictive value for the prediction of SVI were assessed.RESULTS: Overall, 131 patients and 262 SVs were assessable. Of those, 23 (17.5%) men had SVI, and 39 (14.9%) single SVs were infiltrated by tumor overall. The area under the receiver operating characteristic curve for predicting SVI by HS was 0.54. Depending on the HS signal volume cut-offs (>0, >0.2, and >0.5 mL), the sensitivity, specificity, positive predictive value, and negative predictive value for predicting SVI were 76.9%, 10.8%, 13.1%, and 72.7%; 61.5%, 24.2%, 12.4%, and 78.3%; and 46.2%, 50.2%, 14.0%, and 84.2%, respectively.CONCLUSION: HS results did not allow a reliable prediction of SVI within PCa patients. Despite, the application of HS signal volume cut-offs (>0.2 and >0.5 mL), the prediction of SVI within PCa patients remained insufficient.",

keywords = "Aged, Artifacts, Histological Techniques, Humans, Male, Middle Aged, Neoplasm Invasiveness, Predictive Value of Tests, Prognosis, Prospective Studies, Prostatectomy, Prostatic Neoplasms, ROC Curve, Retrospective Studies, Seminal Vesicles, Sensitivity and Specificity, Treatment Outcome",

author = "Jonas Schiffmann and Burkhard Beyer and Johannes Fischer and Pierre Tennstedt and Katharina Boehm and Uwe Michl and Markus Graefen and Georg Salomon",

year = "2014",

month = nov,

day = "1",

doi = "10.1016/j.urology.2014.06.050",

language = "English",

volume = "84",

pages = "1168--71",

journal = "UROLOGY",

issn = "0090-4295",

publisher = "Elsevier Inc.",

number = "5",

}

RIS

TY - JOUR

T1 - Histoscanning has low sensitivity and specificity for seminal vesicle invasion

AU - Schiffmann, Jonas

AU - Beyer, Burkhard

AU - Fischer, Johannes

AU - Tennstedt, Pierre

AU - Boehm, Katharina

AU - Michl, Uwe

AU - Graefen, Markus

AU - Salomon, Georg

PY - 2014/11/1

Y1 - 2014/11/1

N2 - OBJECTIVE: To examine the accuracy of HistoScanning (HS) in detecting seminal vesicle (SV) invasion (SVI) within prostate cancer (PCa) patients.METHODS: We relied on our prospective institutional database. Patients who received HS before radical prostatectomy were included in the study cohort. An experienced HS examiner retrospectively reanalyzed the HS data blinded to patient characteristics and pathologic results. The HS results for every single SV were compared with the corresponding findings from the final pathologic report after radical prostatectomy. An area under the receiver operating characteristic curve for the prediction of SVI by HS was calculated. Depending on HS signal volume cut-offs (>0, >0.2, and >0.5 mL), the sensitivity, specificity, positive predictive value, and negative predictive value for the prediction of SVI were assessed.RESULTS: Overall, 131 patients and 262 SVs were assessable. Of those, 23 (17.5%) men had SVI, and 39 (14.9%) single SVs were infiltrated by tumor overall. The area under the receiver operating characteristic curve for predicting SVI by HS was 0.54. Depending on the HS signal volume cut-offs (>0, >0.2, and >0.5 mL), the sensitivity, specificity, positive predictive value, and negative predictive value for predicting SVI were 76.9%, 10.8%, 13.1%, and 72.7%; 61.5%, 24.2%, 12.4%, and 78.3%; and 46.2%, 50.2%, 14.0%, and 84.2%, respectively.CONCLUSION: HS results did not allow a reliable prediction of SVI within PCa patients. Despite, the application of HS signal volume cut-offs (>0.2 and >0.5 mL), the prediction of SVI within PCa patients remained insufficient.

AB - OBJECTIVE: To examine the accuracy of HistoScanning (HS) in detecting seminal vesicle (SV) invasion (SVI) within prostate cancer (PCa) patients.METHODS: We relied on our prospective institutional database. Patients who received HS before radical prostatectomy were included in the study cohort. An experienced HS examiner retrospectively reanalyzed the HS data blinded to patient characteristics and pathologic results. The HS results for every single SV were compared with the corresponding findings from the final pathologic report after radical prostatectomy. An area under the receiver operating characteristic curve for the prediction of SVI by HS was calculated. Depending on HS signal volume cut-offs (>0, >0.2, and >0.5 mL), the sensitivity, specificity, positive predictive value, and negative predictive value for the prediction of SVI were assessed.RESULTS: Overall, 131 patients and 262 SVs were assessable. Of those, 23 (17.5%) men had SVI, and 39 (14.9%) single SVs were infiltrated by tumor overall. The area under the receiver operating characteristic curve for predicting SVI by HS was 0.54. Depending on the HS signal volume cut-offs (>0, >0.2, and >0.5 mL), the sensitivity, specificity, positive predictive value, and negative predictive value for predicting SVI were 76.9%, 10.8%, 13.1%, and 72.7%; 61.5%, 24.2%, 12.4%, and 78.3%; and 46.2%, 50.2%, 14.0%, and 84.2%, respectively.CONCLUSION: HS results did not allow a reliable prediction of SVI within PCa patients. Despite, the application of HS signal volume cut-offs (>0.2 and >0.5 mL), the prediction of SVI within PCa patients remained insufficient.

KW - Aged

KW - Artifacts

KW - Histological Techniques

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Invasiveness

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Prostatectomy

KW - Prostatic Neoplasms

KW - ROC Curve

KW - Retrospective Studies

KW - Seminal Vesicles

KW - Sensitivity and Specificity

KW - Treatment Outcome

U2 - 10.1016/j.urology.2014.06.050

DO - 10.1016/j.urology.2014.06.050

M3 - SCORING: Journal article

C2 - 25443925

VL - 84

SP - 1168

EP - 1171

JO - UROLOGY

JF - UROLOGY

SN - 0090-4295

IS - 5

ER -