History of fatigue in multiple sclerosis is associated with grey matter atrophy
Standard
History of fatigue in multiple sclerosis is associated with grey matter atrophy. / Palotai, Miklos; Nazeri, Aria; Cavallari, Michele; Healy, Brian C; Glanz, Bonnie; Gold, Stefan M; Weiner, Howard L; Chitnis, Tanuja; Guttmann, Charles R G.
in: SCI REP-UK, Jahrgang 9, Nr. 1, 14.10.2019, S. 14781.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - History of fatigue in multiple sclerosis is associated with grey matter atrophy
AU - Palotai, Miklos
AU - Nazeri, Aria
AU - Cavallari, Michele
AU - Healy, Brian C
AU - Glanz, Bonnie
AU - Gold, Stefan M
AU - Weiner, Howard L
AU - Chitnis, Tanuja
AU - Guttmann, Charles R G
PY - 2019/10/14
Y1 - 2019/10/14
N2 - Fatigue in multiple sclerosis (MS) has been associated with brain damage with low replicability. Temporal fatigue fluctuations have not been considered. We assessed whether sustained fatigue (SF) associates more strongly with grey matter (GM) changes than reversible fatigue (RF). Patients were stratified into three groups according to historical fatigue levels: SF (n = 30, i.e. patients who reported fatigue at the latest ≥2 assessments), RF (n = 31, i.e. patients not fatigued at the latest assessment, but reported fatigue previously), and never fatigued (NF, n = 37). Groups were compared for brain GM volume using cross-sectional voxel-based and volumetric analyses of 3T T1-weighted MRI. Confounding effects of depression and related medications were also investigated. SF and RF patients showed similar anatomical distribution of GM atrophy. While we robustly replicated the anatomical patterns of GM atrophy described in previous work, we also found an association between hippocampal atrophy and fatigue. Depression showed confounding effects in frontal, parietal, occipital, accumbal and thalamic regions. Assessed treatments showed confounding effects in frontal, parietal and striatal areas. Our results suggest that history of clinically-relevant fatigue in currently non-fatigued patients is associated with GM atrophy, potentially explaining inconsistent findings of previous studies that stratified patients using a single fatigue assessment.
AB - Fatigue in multiple sclerosis (MS) has been associated with brain damage with low replicability. Temporal fatigue fluctuations have not been considered. We assessed whether sustained fatigue (SF) associates more strongly with grey matter (GM) changes than reversible fatigue (RF). Patients were stratified into three groups according to historical fatigue levels: SF (n = 30, i.e. patients who reported fatigue at the latest ≥2 assessments), RF (n = 31, i.e. patients not fatigued at the latest assessment, but reported fatigue previously), and never fatigued (NF, n = 37). Groups were compared for brain GM volume using cross-sectional voxel-based and volumetric analyses of 3T T1-weighted MRI. Confounding effects of depression and related medications were also investigated. SF and RF patients showed similar anatomical distribution of GM atrophy. While we robustly replicated the anatomical patterns of GM atrophy described in previous work, we also found an association between hippocampal atrophy and fatigue. Depression showed confounding effects in frontal, parietal, occipital, accumbal and thalamic regions. Assessed treatments showed confounding effects in frontal, parietal and striatal areas. Our results suggest that history of clinically-relevant fatigue in currently non-fatigued patients is associated with GM atrophy, potentially explaining inconsistent findings of previous studies that stratified patients using a single fatigue assessment.
U2 - 10.1038/s41598-019-51110-2
DO - 10.1038/s41598-019-51110-2
M3 - SCORING: Journal article
C2 - 31611598
VL - 9
SP - 14781
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -