History of depression but not current depression is associated with signs of atherosclerosis: data from the Gutenberg Health Study
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History of depression but not current depression is associated with signs of atherosclerosis: data from the Gutenberg Health Study. / Beutel, M E; Wiltink, J; Kirschner, Y; Sinning, C; Espinola-Klein, C; Wild, P S; Münzel, T; Blettner, M; Zwiener, I; Lackner, K; Michal, M.
in: PSYCHOL MED, Jahrgang 44, Nr. 5, 04.2014, S. 919-925.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - History of depression but not current depression is associated with signs of atherosclerosis: data from the Gutenberg Health Study
AU - Beutel, M E
AU - Wiltink, J
AU - Kirschner, Y
AU - Sinning, C
AU - Espinola-Klein, C
AU - Wild, P S
AU - Münzel, T
AU - Blettner, M
AU - Zwiener, I
AU - Lackner, K
AU - Michal, M
PY - 2014/4
Y1 - 2014/4
N2 - OBJECTIVES: To test the vascular depression hypothesis in the general population, we analyzed the association between current depression, medical history of depression, cognitive and somatic depressive symptom dimensions and measures of atherosclerosis [intima-media thickness (IMT) and carotid plaques].METHOD: We included a representative sample of 5000 participants from the Gutenberg Health Study (GHS). Depression was assessed by the nine-item Patient Health Questionnaire (PHQ-9), and IMT and carotid plaques were measured at both common carotid arteries using an edge detection system. Regression analyses were performed separately for participants with and without cardiovascular disease, adjusting for medical history, cardiovascular risk factors and psychotropic medication.RESULTS: Contrary to hypotheses, we found no increased IMT for somatic symptoms of depression; the same was true for depression and cognitive symptoms in the fully adjusted model. Only a moderate relationship between medical history of depression and the presence of atherosclerotic plaques was maintained after correction.CONCLUSIONS: The relationship between depression and atherosclerosis may be more complex than previously assumed. Although the vascular depression hypothesis was not supported, our results support the hypothesis that lasting depression leads to arteriosclerosis.
AB - OBJECTIVES: To test the vascular depression hypothesis in the general population, we analyzed the association between current depression, medical history of depression, cognitive and somatic depressive symptom dimensions and measures of atherosclerosis [intima-media thickness (IMT) and carotid plaques].METHOD: We included a representative sample of 5000 participants from the Gutenberg Health Study (GHS). Depression was assessed by the nine-item Patient Health Questionnaire (PHQ-9), and IMT and carotid plaques were measured at both common carotid arteries using an edge detection system. Regression analyses were performed separately for participants with and without cardiovascular disease, adjusting for medical history, cardiovascular risk factors and psychotropic medication.RESULTS: Contrary to hypotheses, we found no increased IMT for somatic symptoms of depression; the same was true for depression and cognitive symptoms in the fully adjusted model. Only a moderate relationship between medical history of depression and the presence of atherosclerotic plaques was maintained after correction.CONCLUSIONS: The relationship between depression and atherosclerosis may be more complex than previously assumed. Although the vascular depression hypothesis was not supported, our results support the hypothesis that lasting depression leads to arteriosclerosis.
KW - Adult
KW - Aged
KW - Atherosclerosis/diagnosis
KW - Carotid Intima-Media Thickness/statistics & numerical data
KW - Carotid Stenosis/epidemiology
KW - Comorbidity
KW - Depression/diagnosis
KW - Female
KW - Germany/epidemiology
KW - Humans
KW - Male
KW - Middle Aged
U2 - 10.1017/S0033291713001542
DO - 10.1017/S0033291713001542
M3 - SCORING: Journal article
C2 - 23822954
VL - 44
SP - 919
EP - 925
JO - PSYCHOL MED
JF - PSYCHOL MED
SN - 0033-2917
IS - 5
ER -