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Histopathological results of radical prostatectomy specimen of men younger than 50 years of age at the time of surgery: possible implications for prostate cancer screening programs?

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Histopathological results of radical prostatectomy specimen of men younger than 50 years of age at the time of surgery: possible implications for prostate cancer screening programs? / Mehring, Gisa; Tilki, Derya; Heinzer, Hans; Steuber, Thomas; Pose, Randi M; Thederan, Imke; Budäus, Lars; Salomon, Georg; Haese, Alexander; Michl, Uwe; Maurer, Tobias; Huland, Hartwig; Graefen, Markus; Isbarn, Hendrik.

in: WORLD J UROL, Jahrgang 41, Nr. 2, 02.2023, S. 421-425.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mehring, G, Tilki, D, Heinzer, H, Steuber, T, Pose, RM, Thederan, I, Budäus, L, Salomon, G, Haese, A, Michl, U, Maurer, T, Huland, H, Graefen, M & Isbarn, H 2023, 'Histopathological results of radical prostatectomy specimen of men younger than 50 years of age at the time of surgery: possible implications for prostate cancer screening programs?', WORLD J UROL, Jg. 41, Nr. 2, S. 421-425. https://doi.org/10.1007/s00345-023-04287-1

APA

Mehring, G., Tilki, D., Heinzer, H., Steuber, T., Pose, R. M., Thederan, I., Budäus, L., Salomon, G., Haese, A., Michl, U., Maurer, T., Huland, H., Graefen, M., & Isbarn, H. (2023). Histopathological results of radical prostatectomy specimen of men younger than 50 years of age at the time of surgery: possible implications for prostate cancer screening programs? WORLD J UROL, 41(2), 421-425. https://doi.org/10.1007/s00345-023-04287-1

Vancouver

Mehring G, Tilki D, Heinzer H, Steuber T, Pose RM, Thederan I et al. Histopathological results of radical prostatectomy specimen of men younger than 50 years of age at the time of surgery: possible implications for prostate cancer screening programs? WORLD J UROL. 2023 Feb;41(2):421-425. https://doi.org/10.1007/s00345-023-04287-1

Bibtex

@article{36228ba9f0b0495da6330a1358043509,
title = "Histopathological results of radical prostatectomy specimen of men younger than 50 years of age at the time of surgery: possible implications for prostate cancer screening programs?",
abstract = "INTRODUCTION: Prostate cancer (PCa) detection is usually achieved by PSA measurement and, if indicated, further diagnostics. The recent EAU guidelines recommend a first PSA test at the age of 50 years, if no family history of PCa or BRCA2 mutation exists. However, some men might harbor significant PCa at younger age; thus we evaluated the histopathological results of men treated with radical prostatectomy (RP) in their 40 s at our institution.MATERIALS AND METHODS: We relied on the data of all patients who underwent RP in our institution between 1992 and 2020 and were younger than 50 years at the time of surgery. The histopathological results are descriptively presented. Moreover, we tested the effect of a positive family history on the descriptive results.RESULTS: Overall, 1225 patients younger than 50 years underwent RP at our institution. Median age was 47 years. Most patients showed favorable histopathological characteristics. However, 20% of patients had extraprostatic disease (≥ pT3a), 15% had ISUP Gleason grade group ≥ 3, and 7% had positive lymph nodes (pN1). Patients with a known positive family history did not have a higher rate of adverse disease as their counterparts with a negative family history.DISCUSSION: Our data show that the majority of patients who were diagnosed with PCa at a very young age had favorable histopathological RP characteristics. However, a non-negligible proportion of patients already showed locally advanced disease and would have probably benefited from earlier PCa detection. This should be kept in mind when PCa screening recommendations are proposed.",
keywords = "Male, Humans, Middle Aged, Prostatic Neoplasms/pathology, Prostate-Specific Antigen, Early Detection of Cancer, Prostate/pathology, Prostatectomy/methods, Neoplasm Grading",
author = "Gisa Mehring and Derya Tilki and Hans Heinzer and Thomas Steuber and Pose, {Randi M} and Imke Thederan and Lars Bud{\"a}us and Georg Salomon and Alexander Haese and Uwe Michl and Tobias Maurer and Hartwig Huland and Markus Graefen and Hendrik Isbarn",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = feb,
doi = "10.1007/s00345-023-04287-1",
language = "English",
volume = "41",
pages = "421--425",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Histopathological results of radical prostatectomy specimen of men younger than 50 years of age at the time of surgery: possible implications for prostate cancer screening programs?

AU - Mehring, Gisa

AU - Tilki, Derya

AU - Heinzer, Hans

AU - Steuber, Thomas

AU - Pose, Randi M

AU - Thederan, Imke

AU - Budäus, Lars

AU - Salomon, Georg

AU - Haese, Alexander

AU - Michl, Uwe

AU - Maurer, Tobias

AU - Huland, Hartwig

AU - Graefen, Markus

AU - Isbarn, Hendrik

N1 - © 2023. The Author(s).

PY - 2023/2

Y1 - 2023/2

N2 - INTRODUCTION: Prostate cancer (PCa) detection is usually achieved by PSA measurement and, if indicated, further diagnostics. The recent EAU guidelines recommend a first PSA test at the age of 50 years, if no family history of PCa or BRCA2 mutation exists. However, some men might harbor significant PCa at younger age; thus we evaluated the histopathological results of men treated with radical prostatectomy (RP) in their 40 s at our institution.MATERIALS AND METHODS: We relied on the data of all patients who underwent RP in our institution between 1992 and 2020 and were younger than 50 years at the time of surgery. The histopathological results are descriptively presented. Moreover, we tested the effect of a positive family history on the descriptive results.RESULTS: Overall, 1225 patients younger than 50 years underwent RP at our institution. Median age was 47 years. Most patients showed favorable histopathological characteristics. However, 20% of patients had extraprostatic disease (≥ pT3a), 15% had ISUP Gleason grade group ≥ 3, and 7% had positive lymph nodes (pN1). Patients with a known positive family history did not have a higher rate of adverse disease as their counterparts with a negative family history.DISCUSSION: Our data show that the majority of patients who were diagnosed with PCa at a very young age had favorable histopathological RP characteristics. However, a non-negligible proportion of patients already showed locally advanced disease and would have probably benefited from earlier PCa detection. This should be kept in mind when PCa screening recommendations are proposed.

AB - INTRODUCTION: Prostate cancer (PCa) detection is usually achieved by PSA measurement and, if indicated, further diagnostics. The recent EAU guidelines recommend a first PSA test at the age of 50 years, if no family history of PCa or BRCA2 mutation exists. However, some men might harbor significant PCa at younger age; thus we evaluated the histopathological results of men treated with radical prostatectomy (RP) in their 40 s at our institution.MATERIALS AND METHODS: We relied on the data of all patients who underwent RP in our institution between 1992 and 2020 and were younger than 50 years at the time of surgery. The histopathological results are descriptively presented. Moreover, we tested the effect of a positive family history on the descriptive results.RESULTS: Overall, 1225 patients younger than 50 years underwent RP at our institution. Median age was 47 years. Most patients showed favorable histopathological characteristics. However, 20% of patients had extraprostatic disease (≥ pT3a), 15% had ISUP Gleason grade group ≥ 3, and 7% had positive lymph nodes (pN1). Patients with a known positive family history did not have a higher rate of adverse disease as their counterparts with a negative family history.DISCUSSION: Our data show that the majority of patients who were diagnosed with PCa at a very young age had favorable histopathological RP characteristics. However, a non-negligible proportion of patients already showed locally advanced disease and would have probably benefited from earlier PCa detection. This should be kept in mind when PCa screening recommendations are proposed.

KW - Male

KW - Humans

KW - Middle Aged

KW - Prostatic Neoplasms/pathology

KW - Prostate-Specific Antigen

KW - Early Detection of Cancer

KW - Prostate/pathology

KW - Prostatectomy/methods

KW - Neoplasm Grading

U2 - 10.1007/s00345-023-04287-1

DO - 10.1007/s00345-023-04287-1

M3 - SCORING: Journal article

C2 - 36656332

VL - 41

SP - 421

EP - 425

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 2

ER -