Hippocampal-prefrontal encoding activation predicts whether words can be successfully recalled or only recognized
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Hippocampal-prefrontal encoding activation predicts whether words can be successfully recalled or only recognized. / Brassen, Stefanie; Weber-Fahr, Wolfgang; Sommer-Blöchl, Tobias; Lehmbeck, Jan T; Braus, Dieter F.
in: BEHAV BRAIN RES, Jahrgang 171, Nr. 2, 10.08.2006, S. 271-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Hippocampal-prefrontal encoding activation predicts whether words can be successfully recalled or only recognized
AU - Brassen, Stefanie
AU - Weber-Fahr, Wolfgang
AU - Sommer-Blöchl, Tobias
AU - Lehmbeck, Jan T
AU - Braus, Dieter F
PY - 2006/8/10
Y1 - 2006/8/10
N2 - The main goal of the present fMRI-study was to identify the neural correlates underlying the successful encoding of words which can subsequently be freely recalled or recognized but not recalled. We were particularly interested in common as well as distinct neural substrates of both retrieval modes. To assess qualitatively differently activated brain areas, categorical subsequent memory analyses were applied. In addition, we used linear parametric modulation to detect brain regions associated with "memory-strength". Our findings suggest that the successful verbal encoding of words, which were recognized but not recalled relies on a subset of the regions engaged during successful encoding of freely recalled words. Furthermore, it seems to be dependent on the magnitude of relational binding in a prefrontal-hippocampal circuit whether a word can subsequently be recalled freely or only recognized.
AB - The main goal of the present fMRI-study was to identify the neural correlates underlying the successful encoding of words which can subsequently be freely recalled or recognized but not recalled. We were particularly interested in common as well as distinct neural substrates of both retrieval modes. To assess qualitatively differently activated brain areas, categorical subsequent memory analyses were applied. In addition, we used linear parametric modulation to detect brain regions associated with "memory-strength". Our findings suggest that the successful verbal encoding of words, which were recognized but not recalled relies on a subset of the regions engaged during successful encoding of freely recalled words. Furthermore, it seems to be dependent on the magnitude of relational binding in a prefrontal-hippocampal circuit whether a word can subsequently be recalled freely or only recognized.
KW - Adult
KW - Brain Mapping
KW - Female
KW - Hippocampus
KW - Humans
KW - Magnetic Resonance Imaging
KW - Mental Recall
KW - Neural Pathways
KW - Prefrontal Cortex
KW - Recognition (Psychology)
KW - Reference Values
KW - Verbal Learning
KW - Comparative Study
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.bbr.2006.04.002
DO - 10.1016/j.bbr.2006.04.002
M3 - SCORING: Journal article
C2 - 16725214
VL - 171
SP - 271
EP - 278
JO - BEHAV BRAIN RES
JF - BEHAV BRAIN RES
SN - 0166-4328
IS - 2
ER -