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Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.

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Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. / Rosenkranz, Daniela; Weyer, Sascha; Tolosa, Eva; Gaenslen, Alexandra; Berg, Daniela; Leyhe, Thomas; Gasser, Thomas; Stoltze, Lars.

in: J NEUROIMMUNOL, Jahrgang 188, Nr. 1-2, 1-2, 2007, S. 117-127.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rosenkranz, D, Weyer, S, Tolosa, E, Gaenslen, A, Berg, D, Leyhe, T, Gasser, T & Stoltze, L 2007, 'Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.', J NEUROIMMUNOL, Jg. 188, Nr. 1-2, 1-2, S. 117-127. <http://www.ncbi.nlm.nih.gov/pubmed/17582512?dopt=Citation>

APA

Rosenkranz, D., Weyer, S., Tolosa, E., Gaenslen, A., Berg, D., Leyhe, T., Gasser, T., & Stoltze, L. (2007). Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J NEUROIMMUNOL, 188(1-2), 117-127. [1-2]. http://www.ncbi.nlm.nih.gov/pubmed/17582512?dopt=Citation

Vancouver

Rosenkranz D, Weyer S, Tolosa E, Gaenslen A, Berg D, Leyhe T et al. Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J NEUROIMMUNOL. 2007;188(1-2):117-127. 1-2.

Bibtex

@article{d335f04836b34f6eb969d7f82aa56249,
title = "Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.",
abstract = "The involvement of regulatory T cells (Treg) in autoimmune-disease development has been demonstrated. However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. Alzheimer (AD) and Parkinson disease (PD), are related to protein-misfolding and are accompanied by neuroinflammation. Since, it has been hypothesized that the neuroinflammation attempts to prevent disease development, we speculated that changes in Treg might affect any relevant immune mechanism. The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients.",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Age Factors, Case-Control Studies, Forkhead Transcription Factors/metabolism, Aging/*immunology, Alzheimer Disease/*immunology/*pathology, CD4-Positive T-Lymphocytes/physiology, Flow Cytometry/methods, Parkinson Disease/*immunology/*pathology, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory/*physiology, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Age Factors, Case-Control Studies, Forkhead Transcription Factors/metabolism, Aging/*immunology, Alzheimer Disease/*immunology/*pathology, CD4-Positive T-Lymphocytes/physiology, Flow Cytometry/methods, Parkinson Disease/*immunology/*pathology, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory/*physiology",
author = "Daniela Rosenkranz and Sascha Weyer and Eva Tolosa and Alexandra Gaenslen and Daniela Berg and Thomas Leyhe and Thomas Gasser and Lars Stoltze",
year = "2007",
language = "English",
volume = "188",
pages = "117--127",
journal = "J NEUROIMMUNOL",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration.

AU - Rosenkranz, Daniela

AU - Weyer, Sascha

AU - Tolosa, Eva

AU - Gaenslen, Alexandra

AU - Berg, Daniela

AU - Leyhe, Thomas

AU - Gasser, Thomas

AU - Stoltze, Lars

PY - 2007

Y1 - 2007

N2 - The involvement of regulatory T cells (Treg) in autoimmune-disease development has been demonstrated. However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. Alzheimer (AD) and Parkinson disease (PD), are related to protein-misfolding and are accompanied by neuroinflammation. Since, it has been hypothesized that the neuroinflammation attempts to prevent disease development, we speculated that changes in Treg might affect any relevant immune mechanism. The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients.

AB - The involvement of regulatory T cells (Treg) in autoimmune-disease development has been demonstrated. However, their alteration during ageing and age-related diseases has not been thoroughly investigated yet. Alzheimer (AD) and Parkinson disease (PD), are related to protein-misfolding and are accompanied by neuroinflammation. Since, it has been hypothesized that the neuroinflammation attempts to prevent disease development, we speculated that changes in Treg might affect any relevant immune mechanism. The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Age Factors

KW - Case-Control Studies

KW - Forkhead Transcription Factors/metabolism

KW - Aging/immunology

KW - Alzheimer Disease/immunology/pathology

KW - CD4-Positive T-Lymphocytes/physiology

KW - Flow Cytometry/methods

KW - Parkinson Disease/immunology/pathology

KW - T-Lymphocyte Subsets

KW - T-Lymphocytes, Regulatory/physiology

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Age Factors

KW - Case-Control Studies

KW - Forkhead Transcription Factors/metabolism

KW - Aging/immunology

KW - Alzheimer Disease/immunology/pathology

KW - CD4-Positive T-Lymphocytes/physiology

KW - Flow Cytometry/methods

KW - Parkinson Disease/immunology/pathology

KW - T-Lymphocyte Subsets

KW - T-Lymphocytes, Regulatory/physiology

M3 - SCORING: Journal article

VL - 188

SP - 117

EP - 127

JO - J NEUROIMMUNOL

JF - J NEUROIMMUNOL

SN - 0165-5728

IS - 1-2

M1 - 1-2

ER -