High surgical volume is associated with a lower rate of secondary therapy after radical prostatectomy for localized prostate cancer.
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High surgical volume is associated with a lower rate of secondary therapy after radical prostatectomy for localized prostate cancer. / Jeldres, Claudio; Nazareno, Suardi; Capitanio, Umberto; Montorsi, Francesco; Shariat, Shahrokh F; Perrotte, Paul; Peloquin, Francois; Pharand, Daniel; Graefen, Markus; Karakiewicz, Pierre I.
in: BJU INT, Jahrgang 102, Nr. 4, 4, 2008, S. 463-467.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - High surgical volume is associated with a lower rate of secondary therapy after radical prostatectomy for localized prostate cancer.
AU - Jeldres, Claudio
AU - Nazareno, Suardi
AU - Capitanio, Umberto
AU - Montorsi, Francesco
AU - Shariat, Shahrokh F
AU - Perrotte, Paul
AU - Peloquin, Francois
AU - Pharand, Daniel
AU - Graefen, Markus
AU - Karakiewicz, Pierre I
PY - 2008
Y1 - 2008
N2 - OBJECTIVE: To assess the relationship between surgical volume (SV), defined as the number of radical prostatectomies (RPs) within a calendar year, and the time to secondary therapy (ST) after RP, as this might represent an important determinant of cancer control. PATIENTS AND METHODS: The study included 7937 men treated with RP by 130 urologists between 1989 and 2000. Radiotherapy or any form of hormonal manipulation represented ST. Univariable and multivariable Cox regression analyses was used to evaluate the time to ST after RP. RESULTS: SV was an independent (P = 0.02) predictor of ST-free survival after RP, and the multivariable rate of ST sharply decreased with increasing SV. CONCLUSIONS: The use of ST is inversely proportional to SV of up to 24 RPs per year. A higher annual SV might be indicative of less restrictive use of RP in high-risk patients who eventually require combined treatments.
AB - OBJECTIVE: To assess the relationship between surgical volume (SV), defined as the number of radical prostatectomies (RPs) within a calendar year, and the time to secondary therapy (ST) after RP, as this might represent an important determinant of cancer control. PATIENTS AND METHODS: The study included 7937 men treated with RP by 130 urologists between 1989 and 2000. Radiotherapy or any form of hormonal manipulation represented ST. Univariable and multivariable Cox regression analyses was used to evaluate the time to ST after RP. RESULTS: SV was an independent (P = 0.02) predictor of ST-free survival after RP, and the multivariable rate of ST sharply decreased with increasing SV. CONCLUSIONS: The use of ST is inversely proportional to SV of up to 24 RPs per year. A higher annual SV might be indicative of less restrictive use of RP in high-risk patients who eventually require combined treatments.
M3 - SCORING: Zeitschriftenaufsatz
VL - 102
SP - 463
EP - 467
JO - BJU INT
JF - BJU INT
SN - 1464-4096
IS - 4
M1 - 4
ER -