High resolution optical mapping of cardiac electrophysiology in pre-clinical models
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High resolution optical mapping of cardiac electrophysiology in pre-clinical models. / O'Shea, Christopher; Winter, James; Kabir, S Nashitha; O'Reilly, Molly; Wells, Simon P; Baines, Olivia; Sommerfeld, Laura C; Correia, Joao; Lei, Ming; Kirchhof, Paulus; Holmes, Andrew P; Fabritz, Larissa; Rajpoot, Kashif; Pavlovic, Davor.
in: SCI DATA, Jahrgang 9, Nr. 1, 135, 31.03.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - High resolution optical mapping of cardiac electrophysiology in pre-clinical models
AU - O'Shea, Christopher
AU - Winter, James
AU - Kabir, S Nashitha
AU - O'Reilly, Molly
AU - Wells, Simon P
AU - Baines, Olivia
AU - Sommerfeld, Laura C
AU - Correia, Joao
AU - Lei, Ming
AU - Kirchhof, Paulus
AU - Holmes, Andrew P
AU - Fabritz, Larissa
AU - Rajpoot, Kashif
AU - Pavlovic, Davor
N1 - © 2022. The Author(s).
PY - 2022/3/31
Y1 - 2022/3/31
N2 - Optical mapping of animal models is a widely used technique in pre-clinical cardiac research. It has several advantages over other methods, including higher spatial resolution, contactless recording and direct visualisation of action potentials and calcium transients. Optical mapping enables simultaneous study of action potential and calcium transient morphology, conduction dynamics, regional heterogeneity, restitution and arrhythmogenesis. In this dataset, we have optically mapped Langendorff perfused isolated whole hearts (mouse and guinea pig) and superfused isolated atria (mouse). Raw datasets (consisting of over 400 files) can be combined with open-source software for processing and analysis. We have generated a comprehensive post-processed dataset characterising the baseline cardiac electrophysiology in these widely used pre-clinical models. This dataset also provides reference information detailing the effect of heart rate, clinically used anti-arrhythmic drugs, ischaemia-reperfusion and sympathetic nervous stimulation on cardiac electrophysiology. The effects of these interventions can be studied in a global or regional manner, enabling new insights into the prevention and initiation of arrhythmia.
AB - Optical mapping of animal models is a widely used technique in pre-clinical cardiac research. It has several advantages over other methods, including higher spatial resolution, contactless recording and direct visualisation of action potentials and calcium transients. Optical mapping enables simultaneous study of action potential and calcium transient morphology, conduction dynamics, regional heterogeneity, restitution and arrhythmogenesis. In this dataset, we have optically mapped Langendorff perfused isolated whole hearts (mouse and guinea pig) and superfused isolated atria (mouse). Raw datasets (consisting of over 400 files) can be combined with open-source software for processing and analysis. We have generated a comprehensive post-processed dataset characterising the baseline cardiac electrophysiology in these widely used pre-clinical models. This dataset also provides reference information detailing the effect of heart rate, clinically used anti-arrhythmic drugs, ischaemia-reperfusion and sympathetic nervous stimulation on cardiac electrophysiology. The effects of these interventions can be studied in a global or regional manner, enabling new insights into the prevention and initiation of arrhythmia.
KW - Action Potentials/physiology
KW - Animals
KW - Arrhythmias, Cardiac/diagnostic imaging
KW - Calcium/physiology
KW - Electrophysiologic Techniques, Cardiac
KW - Heart Rate
KW - Models, Animal
U2 - 10.1038/s41597-022-01253-1
DO - 10.1038/s41597-022-01253-1
M3 - SCORING: Journal article
C2 - 35361792
VL - 9
JO - SCI DATA
JF - SCI DATA
SN - 2052-4463
IS - 1
M1 - 135
ER -
