High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients
Standard
High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients. / El Gammal, Alexander Tarek; Melling, Nathaniel; Reeh, Matthias; Gebauer, Florian; Mann, Oliver; Perez, Daniel; Bockhorn, Maximillian; Bachmann, Kai; Izbicki, Jakob Robert; Grupp, Katharina.
in: EXP MOL PATHOL, Jahrgang 107, 04.2019, S. 51-56.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients
AU - El Gammal, Alexander Tarek
AU - Melling, Nathaniel
AU - Reeh, Matthias
AU - Gebauer, Florian
AU - Mann, Oliver
AU - Perez, Daniel
AU - Bockhorn, Maximillian
AU - Bachmann, Kai
AU - Izbicki, Jakob Robert
AU - Grupp, Katharina
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019/4
Y1 - 2019/4
N2 - Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in esophageal cancers remains unclear. Immunohistochemical RAI3 staining was analyzed on tissue microarrays containing 359 esophageal adenocarcinomas (EAC) and 254 esophageal squamous cell carcinomas (ESCC). RAI3 immunostaining was typically absent or weakly detectable in the membranes in benign esophageal tissues. RAI3 staining was higher in malignant than in benign esophagus epithelium. High-levels of RAI3 staining were found in 79.2% of interpretable EACs and 55.9% of ESCCs. In EACs, strong RAI3 staining was associated with advanced pathological tumor stage (p < .0001), high UICC stage (p < .0001), high tumor grade (p = .0133), and positive lymph nodal status (p = .0002). Additionally, high RAI3 staining predicted shortened overall survival of EAC and ESCC patients (p = .0298 and p = .0227). RAI3 overexpression is associated with poor prognosis in esophageal cancers. We propose that RAI3 overexpression might play a biologically relevant role of RAI3 in esophageal cancers.
AB - Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in esophageal cancers remains unclear. Immunohistochemical RAI3 staining was analyzed on tissue microarrays containing 359 esophageal adenocarcinomas (EAC) and 254 esophageal squamous cell carcinomas (ESCC). RAI3 immunostaining was typically absent or weakly detectable in the membranes in benign esophageal tissues. RAI3 staining was higher in malignant than in benign esophagus epithelium. High-levels of RAI3 staining were found in 79.2% of interpretable EACs and 55.9% of ESCCs. In EACs, strong RAI3 staining was associated with advanced pathological tumor stage (p < .0001), high UICC stage (p < .0001), high tumor grade (p = .0133), and positive lymph nodal status (p = .0002). Additionally, high RAI3 staining predicted shortened overall survival of EAC and ESCC patients (p = .0298 and p = .0227). RAI3 overexpression is associated with poor prognosis in esophageal cancers. We propose that RAI3 overexpression might play a biologically relevant role of RAI3 in esophageal cancers.
KW - Adenocarcinoma/mortality
KW - Adult
KW - Aged
KW - Biomarkers, Tumor/analysis
KW - Esophageal Neoplasms/mortality
KW - Esophageal Squamous Cell Carcinoma/mortality
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Receptors, G-Protein-Coupled/biosynthesis
U2 - 10.1016/j.yexmp.2019.01.013
DO - 10.1016/j.yexmp.2019.01.013
M3 - SCORING: Journal article
C2 - 30707896
VL - 107
SP - 51
EP - 56
JO - EXP MOL PATHOL
JF - EXP MOL PATHOL
SN - 0014-4800
ER -