High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series.
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High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series. / Walz, Jochen; Graefen, Markus; Chun, Felix K-H; Erbersdobler, Andreas; Haese, Alexander; Steuber, Thomas; Schlomm, Thorsten; Huland, Hartwig; Karakiewicz, Pierre I.
in: EUR UROL, Jahrgang 50, Nr. 3, 3, 2006, S. 498-505.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series.
AU - Walz, Jochen
AU - Graefen, Markus
AU - Chun, Felix K-H
AU - Erbersdobler, Andreas
AU - Haese, Alexander
AU - Steuber, Thomas
AU - Schlomm, Thorsten
AU - Huland, Hartwig
AU - Karakiewicz, Pierre I
PY - 2006
Y1 - 2006
N2 - OBJECTIVES: We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy. MATERIALS AND METHODS: Between 2001 and 2004, saturation biopsies (average of 24 cores) were performed in 161 men with persistently elevated prostate specific antigen (PSA) level (median, 9 ng/ml). All had at least two previously negative, eight-core biopsy sessions. PCa predictors on saturation biopsy were integrated within multivariate nomograms. RESULTS: PCa detection was 41% (n=66 of 161). PSA density and transition zone volume were the most significant predictors of PCa on saturation biopsy. The accuracy of the nomogram with the best performance characteristics was 72%. CONCLUSIONS: Saturation biopsy may be indicated in men with a persistent suspicion of PCa. High-risk individuals can be identified accurately with our nomogram.
AB - OBJECTIVES: We explored the yield of saturation biopsy and developed a nomogram predicting the probability of prostate cancer (PCa) on the basis of saturation biopsy. MATERIALS AND METHODS: Between 2001 and 2004, saturation biopsies (average of 24 cores) were performed in 161 men with persistently elevated prostate specific antigen (PSA) level (median, 9 ng/ml). All had at least two previously negative, eight-core biopsy sessions. PCa predictors on saturation biopsy were integrated within multivariate nomograms. RESULTS: PCa detection was 41% (n=66 of 161). PSA density and transition zone volume were the most significant predictors of PCa on saturation biopsy. The accuracy of the nomogram with the best performance characteristics was 72%. CONCLUSIONS: Saturation biopsy may be indicated in men with a persistent suspicion of PCa. High-risk individuals can be identified accurately with our nomogram.
M3 - SCORING: Zeitschriftenaufsatz
VL - 50
SP - 498
EP - 505
JO - EUR UROL
JF - EUR UROL
SN - 0302-2838
IS - 3
M1 - 3
ER -