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Heterogeneity of miR-10b expression in circulating tumor cells

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Heterogeneity of miR-10b expression in circulating tumor cells. / Gasch, Christin; Plummer, Prue N; Jovanovic, Lidija; McInnes, Linda M; Wescott, David; Saunders, Christobel M; Schneeweiss, Andreas; Wallwiener, Markus; Nelson, Colleen; Spring, Kevin J; Riethdorf, Sabine; Thompson, Erik W; Pantel, Klaus; Mellick, Albert S.

in: SCI REP-UK, Jahrgang 5, 02.11.2015, S. Art. 15980.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gasch, C, Plummer, PN, Jovanovic, L, McInnes, LM, Wescott, D, Saunders, CM, Schneeweiss, A, Wallwiener, M, Nelson, C, Spring, KJ, Riethdorf, S, Thompson, EW, Pantel, K & Mellick, AS 2015, 'Heterogeneity of miR-10b expression in circulating tumor cells', SCI REP-UK, Jg. 5, S. Art. 15980. https://doi.org/10.1038/srep15980

APA

Gasch, C., Plummer, P. N., Jovanovic, L., McInnes, L. M., Wescott, D., Saunders, C. M., Schneeweiss, A., Wallwiener, M., Nelson, C., Spring, K. J., Riethdorf, S., Thompson, E. W., Pantel, K., & Mellick, A. S. (2015). Heterogeneity of miR-10b expression in circulating tumor cells. SCI REP-UK, 5, Art. 15980. https://doi.org/10.1038/srep15980

Vancouver

Gasch C, Plummer PN, Jovanovic L, McInnes LM, Wescott D, Saunders CM et al. Heterogeneity of miR-10b expression in circulating tumor cells. SCI REP-UK. 2015 Nov 2;5:Art. 15980. https://doi.org/10.1038/srep15980

Bibtex

@article{614478c6c80949119490de8dac7ea2dd,
title = "Heterogeneity of miR-10b expression in circulating tumor cells",
abstract = "Circulating tumor cells (CTCs) in the blood of cancer patients are recognized as important potential targets for future anticancer therapies. As mediators of metastatic spread, CTCs are also promising to be used as 'liquid biopsy' to aid clinical decision-making. Recent work has revealed potentially important genotypic and phenotypic heterogeneity within CTC populations, even within the same patient. MicroRNAs (miRNAs) are key regulators of gene expression and have emerged as potentially important diagnostic markers and targets for anti-cancer therapy. Here, we describe a robust in situ hybridization (ISH) protocol, incorporating the CellSearch({\textregistered}) CTC detection system, enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis. We also use this method to demonstrate heterogeneity of such as miR-10b on a cell-by-cell basis. We also use this method to demonstrate heterogeneity of miR-10b in individual CTCs from breast, prostate and colorectal cancer patients.",
author = "Christin Gasch and Plummer, {Prue N} and Lidija Jovanovic and McInnes, {Linda M} and David Wescott and Saunders, {Christobel M} and Andreas Schneeweiss and Markus Wallwiener and Colleen Nelson and Spring, {Kevin J} and Sabine Riethdorf and Thompson, {Erik W} and Klaus Pantel and Mellick, {Albert S}",
year = "2015",
month = nov,
day = "2",
doi = "10.1038/srep15980",
language = "English",
volume = "5",
pages = "Art. 15980",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Heterogeneity of miR-10b expression in circulating tumor cells

AU - Gasch, Christin

AU - Plummer, Prue N

AU - Jovanovic, Lidija

AU - McInnes, Linda M

AU - Wescott, David

AU - Saunders, Christobel M

AU - Schneeweiss, Andreas

AU - Wallwiener, Markus

AU - Nelson, Colleen

AU - Spring, Kevin J

AU - Riethdorf, Sabine

AU - Thompson, Erik W

AU - Pantel, Klaus

AU - Mellick, Albert S

PY - 2015/11/2

Y1 - 2015/11/2

N2 - Circulating tumor cells (CTCs) in the blood of cancer patients are recognized as important potential targets for future anticancer therapies. As mediators of metastatic spread, CTCs are also promising to be used as 'liquid biopsy' to aid clinical decision-making. Recent work has revealed potentially important genotypic and phenotypic heterogeneity within CTC populations, even within the same patient. MicroRNAs (miRNAs) are key regulators of gene expression and have emerged as potentially important diagnostic markers and targets for anti-cancer therapy. Here, we describe a robust in situ hybridization (ISH) protocol, incorporating the CellSearch(®) CTC detection system, enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis. We also use this method to demonstrate heterogeneity of such as miR-10b on a cell-by-cell basis. We also use this method to demonstrate heterogeneity of miR-10b in individual CTCs from breast, prostate and colorectal cancer patients.

AB - Circulating tumor cells (CTCs) in the blood of cancer patients are recognized as important potential targets for future anticancer therapies. As mediators of metastatic spread, CTCs are also promising to be used as 'liquid biopsy' to aid clinical decision-making. Recent work has revealed potentially important genotypic and phenotypic heterogeneity within CTC populations, even within the same patient. MicroRNAs (miRNAs) are key regulators of gene expression and have emerged as potentially important diagnostic markers and targets for anti-cancer therapy. Here, we describe a robust in situ hybridization (ISH) protocol, incorporating the CellSearch(®) CTC detection system, enabling clinical investigation of important miRNAs, such as miR-10b on a cell by cell basis. We also use this method to demonstrate heterogeneity of such as miR-10b on a cell-by-cell basis. We also use this method to demonstrate heterogeneity of miR-10b in individual CTCs from breast, prostate and colorectal cancer patients.

U2 - 10.1038/srep15980

DO - 10.1038/srep15980

M3 - SCORING: Journal article

C2 - 26522916

VL - 5

SP - Art. 15980

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -