Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine
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Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine. / Brandner, Johanna M; Schulzke, Jörg D.
in: CELL TISSUE RES, Jahrgang 360, Nr. 3, 08.02.2015, S. 723-748.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine
AU - Brandner, Johanna M
AU - Schulzke, Jörg D
PY - 2015/2/8
Y1 - 2015/2/8
N2 - The tight junction (TJ) regulates paracellular barrier properties. TJs are composed of transmembrane proteins, i.e., claudins, occludin, tricellulin and junctional adhesion molecules as well as TJ plaque proteins. Their relative abundance and composition determines epithelial tightness. TJs undergo rapid regulation by various signalling pathways, either directly addressing TJ transmembrane proteins or via plaque proteins and the cytoskeleton. In the skin, TJs exert predominantly barrier functions, while in the intestine they also mediate paracellular ion and water transport. In diseases, TJs can either be primarily affected (hereditary TJ defects) or changes can result from secondary regulatory inputs as, e.g., in inflammatory diseases (secondary TJ defects). Secondary TJ defects can maintain disease activity, e.g., by enhanced antigen leak. This review discusses TJ composition, function and regulation as well as primary and secondary tight junction defects in a comparative manner in skin and intestine in order to elucidate similarities and differences.
AB - The tight junction (TJ) regulates paracellular barrier properties. TJs are composed of transmembrane proteins, i.e., claudins, occludin, tricellulin and junctional adhesion molecules as well as TJ plaque proteins. Their relative abundance and composition determines epithelial tightness. TJs undergo rapid regulation by various signalling pathways, either directly addressing TJ transmembrane proteins or via plaque proteins and the cytoskeleton. In the skin, TJs exert predominantly barrier functions, while in the intestine they also mediate paracellular ion and water transport. In diseases, TJs can either be primarily affected (hereditary TJ defects) or changes can result from secondary regulatory inputs as, e.g., in inflammatory diseases (secondary TJ defects). Secondary TJ defects can maintain disease activity, e.g., by enhanced antigen leak. This review discusses TJ composition, function and regulation as well as primary and secondary tight junction defects in a comparative manner in skin and intestine in order to elucidate similarities and differences.
U2 - 10.1007/s00441-014-2096-1
DO - 10.1007/s00441-014-2096-1
M3 - SCORING: Journal article
C2 - 25663273
VL - 360
SP - 723
EP - 748
JO - CELL TISSUE RES
JF - CELL TISSUE RES
SN - 0302-766X
IS - 3
ER -