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Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana

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Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana. / Sarfo, Fred Stephen; Eberhardt, Kirsten Alexandra; Dompreh, Albert; Kuffour, Edmund Osei; Soltau, Mareike; Schachscheider, Marei; Drexler, Jan Felix; Eis-Hübinger, Anna Maria; Häussinger, Dieter; Oteng-Seifah, Emelia Efua; Bedu-Addo, George; Phillips, Richard Odame; Norman, Betty; Burchard, Gerd; Feldt, Torsten.

in: PLOS ONE, Jahrgang 10, Nr. 11, 2015, S. e0143388.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sarfo, FS, Eberhardt, KA, Dompreh, A, Kuffour, EO, Soltau, M, Schachscheider, M, Drexler, JF, Eis-Hübinger, AM, Häussinger, D, Oteng-Seifah, EE, Bedu-Addo, G, Phillips, RO, Norman, B, Burchard, G & Feldt, T 2015, 'Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana', PLOS ONE, Jg. 10, Nr. 11, S. e0143388. https://doi.org/10.1371/journal.pone.0143388

APA

Sarfo, F. S., Eberhardt, K. A., Dompreh, A., Kuffour, E. O., Soltau, M., Schachscheider, M., Drexler, J. F., Eis-Hübinger, A. M., Häussinger, D., Oteng-Seifah, E. E., Bedu-Addo, G., Phillips, R. O., Norman, B., Burchard, G., & Feldt, T. (2015). Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana. PLOS ONE, 10(11), e0143388. https://doi.org/10.1371/journal.pone.0143388

Vancouver

Sarfo FS, Eberhardt KA, Dompreh A, Kuffour EO, Soltau M, Schachscheider M et al. Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana. PLOS ONE. 2015;10(11):e0143388. https://doi.org/10.1371/journal.pone.0143388

Bibtex

@article{4bea8b91146c4467bcf9271a5606c681,
title = "Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Na{\"i}ve HIV-Positive Patients in Ghana",
abstract = "BACKGROUND: Worldwide, there is a high co-endemicity of HIV and H. pylori infection and there is growing evidence that H. pylori co-infection is associated with parameters of HIV disease progression. The objective of this study was to investigate the prevalence of H. pylori infection, and the association with clinical, immunological and virological parameters in a large cohort of HIV-infected individuals and uninfected controls in a West African country.METHODS: HIV-patients (n = 1,095) and HIV-negative individuals (n = 107) were recruited at a university hospital in Ghana. H. pylori status was determined using stool antigen testing. HIV-related, clinical and socio-demographic parameters were recorded and analyzed according to H. pylori status.RESULTS: The prevalence of H. pylori infection was significantly lower in HIV-positive compared to HIV-negative individuals (51.5 vs. 88%, p<0.0001). In HIV patients, H. pylori prevalence decreased in parallel with CD4+ T cell counts. In ART-na{\"i}ve HIV-infected individuals, but not in those taking ART, H. pylori infection was associated with higher CD4 cell counts (312 vs. 189 cells/μL, p<0.0001) and lower HIV-1 viral loads (4.92 vs. 5.21 log10 copies/mL, p = 0.006). The findings could not be explained by socio-demographic confounders or reported use of antibiotics. Having no access to tap water and higher CD4+ T cell counts were identified as risk factors for H. pylori infection.CONCLUSIONS: H. pylori prevalence was inversely correlated with the degree of immunosuppression. In ART-na{\"i}ve individuals, H. pylori infection is associated with favorable immunological and virological parameters. The underlying mechanisms for this association are unclear and warrant investigation.",
keywords = "Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-CD8 Ratio, Coinfection, Female, Ghana/epidemiology, HIV Infections/drug therapy, HIV-1/immunology, Helicobacter Infections/epidemiology, Helicobacter pylori/immunology, Humans, Male, Middle Aged, Prevalence, Risk Factors, Socioeconomic Factors, Viral Load, Young Adult",
author = "Sarfo, {Fred Stephen} and Eberhardt, {Kirsten Alexandra} and Albert Dompreh and Kuffour, {Edmund Osei} and Mareike Soltau and Marei Schachscheider and Drexler, {Jan Felix} and Eis-H{\"u}binger, {Anna Maria} and Dieter H{\"a}ussinger and Oteng-Seifah, {Emelia Efua} and George Bedu-Addo and Phillips, {Richard Odame} and Betty Norman and Gerd Burchard and Torsten Feldt",
year = "2015",
doi = "10.1371/journal.pone.0143388",
language = "English",
volume = "10",
pages = "e0143388",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana

AU - Sarfo, Fred Stephen

AU - Eberhardt, Kirsten Alexandra

AU - Dompreh, Albert

AU - Kuffour, Edmund Osei

AU - Soltau, Mareike

AU - Schachscheider, Marei

AU - Drexler, Jan Felix

AU - Eis-Hübinger, Anna Maria

AU - Häussinger, Dieter

AU - Oteng-Seifah, Emelia Efua

AU - Bedu-Addo, George

AU - Phillips, Richard Odame

AU - Norman, Betty

AU - Burchard, Gerd

AU - Feldt, Torsten

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Worldwide, there is a high co-endemicity of HIV and H. pylori infection and there is growing evidence that H. pylori co-infection is associated with parameters of HIV disease progression. The objective of this study was to investigate the prevalence of H. pylori infection, and the association with clinical, immunological and virological parameters in a large cohort of HIV-infected individuals and uninfected controls in a West African country.METHODS: HIV-patients (n = 1,095) and HIV-negative individuals (n = 107) were recruited at a university hospital in Ghana. H. pylori status was determined using stool antigen testing. HIV-related, clinical and socio-demographic parameters were recorded and analyzed according to H. pylori status.RESULTS: The prevalence of H. pylori infection was significantly lower in HIV-positive compared to HIV-negative individuals (51.5 vs. 88%, p<0.0001). In HIV patients, H. pylori prevalence decreased in parallel with CD4+ T cell counts. In ART-naïve HIV-infected individuals, but not in those taking ART, H. pylori infection was associated with higher CD4 cell counts (312 vs. 189 cells/μL, p<0.0001) and lower HIV-1 viral loads (4.92 vs. 5.21 log10 copies/mL, p = 0.006). The findings could not be explained by socio-demographic confounders or reported use of antibiotics. Having no access to tap water and higher CD4+ T cell counts were identified as risk factors for H. pylori infection.CONCLUSIONS: H. pylori prevalence was inversely correlated with the degree of immunosuppression. In ART-naïve individuals, H. pylori infection is associated with favorable immunological and virological parameters. The underlying mechanisms for this association are unclear and warrant investigation.

AB - BACKGROUND: Worldwide, there is a high co-endemicity of HIV and H. pylori infection and there is growing evidence that H. pylori co-infection is associated with parameters of HIV disease progression. The objective of this study was to investigate the prevalence of H. pylori infection, and the association with clinical, immunological and virological parameters in a large cohort of HIV-infected individuals and uninfected controls in a West African country.METHODS: HIV-patients (n = 1,095) and HIV-negative individuals (n = 107) were recruited at a university hospital in Ghana. H. pylori status was determined using stool antigen testing. HIV-related, clinical and socio-demographic parameters were recorded and analyzed according to H. pylori status.RESULTS: The prevalence of H. pylori infection was significantly lower in HIV-positive compared to HIV-negative individuals (51.5 vs. 88%, p<0.0001). In HIV patients, H. pylori prevalence decreased in parallel with CD4+ T cell counts. In ART-naïve HIV-infected individuals, but not in those taking ART, H. pylori infection was associated with higher CD4 cell counts (312 vs. 189 cells/μL, p<0.0001) and lower HIV-1 viral loads (4.92 vs. 5.21 log10 copies/mL, p = 0.006). The findings could not be explained by socio-demographic confounders or reported use of antibiotics. Having no access to tap water and higher CD4+ T cell counts were identified as risk factors for H. pylori infection.CONCLUSIONS: H. pylori prevalence was inversely correlated with the degree of immunosuppression. In ART-naïve individuals, H. pylori infection is associated with favorable immunological and virological parameters. The underlying mechanisms for this association are unclear and warrant investigation.

KW - Adult

KW - Antiretroviral Therapy, Highly Active

KW - CD4 Lymphocyte Count

KW - CD4-CD8 Ratio

KW - Coinfection

KW - Female

KW - Ghana/epidemiology

KW - HIV Infections/drug therapy

KW - HIV-1/immunology

KW - Helicobacter Infections/epidemiology

KW - Helicobacter pylori/immunology

KW - Humans

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Risk Factors

KW - Socioeconomic Factors

KW - Viral Load

KW - Young Adult

U2 - 10.1371/journal.pone.0143388

DO - 10.1371/journal.pone.0143388

M3 - SCORING: Journal article

C2 - 26599971

VL - 10

SP - e0143388

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 11

ER -