Health-related quality of life in patients with Gilles de la Tourette's syndrome.
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Health-related quality of life in patients with Gilles de la Tourette's syndrome. / Müller-Vahl, Kirsten; Dodel, Ines; Müller, Norbert; Münchau, Alexander; Reese, Jens Peter; Balzer-Geldsetzer, Monika; Dodel, Richard; Oertel, Wolfgang H.
in: MOVEMENT DISORD, Jahrgang 25, Nr. 3, 3, 2010, S. 309-314.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Health-related quality of life in patients with Gilles de la Tourette's syndrome.
AU - Müller-Vahl, Kirsten
AU - Dodel, Ines
AU - Müller, Norbert
AU - Münchau, Alexander
AU - Reese, Jens Peter
AU - Balzer-Geldsetzer, Monika
AU - Dodel, Richard
AU - Oertel, Wolfgang H
PY - 2010
Y1 - 2010
N2 - To investigate the health-related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 +/- 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi-structured, self-rating interview. HrQoL was measured using the EQ-5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette-syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self-care (6.6%). The mean EQ-5D visual analog scale (EQ-VAS) was 65.4 +/- 21.9. The patients had a mean BDI score of 12.3 +/- 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 +/- 5.2. The mean STSSS value was 3.2 +/- 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R(2) = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co-morbidities such as depression should be diagnosed and treated vigorously.
AB - To investigate the health-related quality of life (HrQoL) of adult patients with Gilles de la Tourette's syndrome (GTS) in Germany. HrQoL was evaluated in 200 adult patients with GTS (Mean age: 34.9 +/- 11.8 years). Patients were recruited from three outpatient departments in Germany and completed a semi-structured, self-rating interview. HrQoL was measured using the EQ-5D. Depression was assessed using the Beck's depression inventory (BDI) and clinical symptoms using the Yale Tourette syndrome symptom list (TSSL) and the Shapiro Tourette-syndrome severity scale (STSSS). Multivariate regression analyses were performed to identify independent predictors of HrQoL. Patients with GTS proved to have a worse HrQoL than a sample from the general German population. The domains most affected were anxiety/depression (57.1%), followed by pain/discomfort (47.5%), usual activities (38.4%), mobility (14%), and self-care (6.6%). The mean EQ-5D visual analog scale (EQ-VAS) was 65.4 +/- 21.9. The patients had a mean BDI score of 12.3 +/- 9.9, which was considerably worse compared to a healthy group who had a score of 6.45 +/- 5.2. The mean STSSS value was 3.2 +/- 1.1. In multivariate analyses, depressive symptoms contributed considerably, whereas the severity of symptoms as well as age only contributed minimally to HrQoL in the model (R(2) = 0.54). HrQoL is considerably reduced in adult patients with GTS. The main independent factors for determining HrQoL were depression, severity of symptoms, and age. Although, treatment of tics is important, co-morbidities such as depression should be diagnosed and treated vigorously.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Psychiatric Status Rating Scales
KW - Questionnaires
KW - Severity of Illness Index
KW - Sex Factors
KW - Health Status
KW - Pain Measurement
KW - Age Factors
KW - Outcome Assessment (Health Care)
KW - Quality of Life psychology
KW - Self Care
KW - Tourette Syndrome physiopathology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Psychiatric Status Rating Scales
KW - Questionnaires
KW - Severity of Illness Index
KW - Sex Factors
KW - Health Status
KW - Pain Measurement
KW - Age Factors
KW - Outcome Assessment (Health Care)
KW - Quality of Life psychology
KW - Self Care
KW - Tourette Syndrome physiopathology
M3 - SCORING: Journal article
VL - 25
SP - 309
EP - 314
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 3
M1 - 3
ER -
