HBsAg level at time of liver transplantation determines HBsAg decrease and anti-HBs increase and affects HBV DNA decrease during early immunoglobulin administration.
Standard
HBsAg level at time of liver transplantation determines HBsAg decrease and anti-HBs increase and affects HBV DNA decrease during early immunoglobulin administration. / Rosenau, Jens; Kreutz, Therese; Kujawa, Matthias; Bahr, Matthias J; Rifai, Kinan; Hooman, Nazanin; Finger, Andrea; Michel, Gerd; Nashan, Björn; Kuse, Ernst R; Klempnauer, Jürgen; Tillmann, Hans L; Manns, Michael P.
in: J HEPATOL, Jahrgang 46, Nr. 4, 4, 2007, S. 635-644.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - HBsAg level at time of liver transplantation determines HBsAg decrease and anti-HBs increase and affects HBV DNA decrease during early immunoglobulin administration.
AU - Rosenau, Jens
AU - Kreutz, Therese
AU - Kujawa, Matthias
AU - Bahr, Matthias J
AU - Rifai, Kinan
AU - Hooman, Nazanin
AU - Finger, Andrea
AU - Michel, Gerd
AU - Nashan, Björn
AU - Kuse, Ernst R
AU - Klempnauer, Jürgen
AU - Tillmann, Hans L
AU - Manns, Michael P
PY - 2007
Y1 - 2007
N2 - BACKGROUND/AIMS: Administration of hepatitis B immunoglobulin (HBIG) initially after liver transplantation of hepatitis B patients is considered important to prevent reinfection reliably. However, dosing schedules differ considerably between centers. We measured HBsAg, anti-HBs and HBV DNA kinetics to create a rational basis for dosing schemes. METHODS: Thirteen patients (group A) received 10,000 IU HBIG in the anhepatic phase followed by 10,000 IU daily until HBsAg became negative, whereas five patients (group B) received 20,000 IU followed by 5000 IU every 30 min. RESULTS: HBsAg levels at time of transplantation ranged from 0.12 to 12,990 IU/ml. Correlations between initial HBsAg and HBIG required to decrease HBsAg below 1 IU/ml were high in groups A and B (r=0.97, p
AB - BACKGROUND/AIMS: Administration of hepatitis B immunoglobulin (HBIG) initially after liver transplantation of hepatitis B patients is considered important to prevent reinfection reliably. However, dosing schedules differ considerably between centers. We measured HBsAg, anti-HBs and HBV DNA kinetics to create a rational basis for dosing schemes. METHODS: Thirteen patients (group A) received 10,000 IU HBIG in the anhepatic phase followed by 10,000 IU daily until HBsAg became negative, whereas five patients (group B) received 20,000 IU followed by 5000 IU every 30 min. RESULTS: HBsAg levels at time of transplantation ranged from 0.12 to 12,990 IU/ml. Correlations between initial HBsAg and HBIG required to decrease HBsAg below 1 IU/ml were high in groups A and B (r=0.97, p
M3 - SCORING: Zeitschriftenaufsatz
VL - 46
SP - 635
EP - 644
JO - J HEPATOL
JF - J HEPATOL
SN - 0168-8278
IS - 4
M1 - 4
ER -