Harnessing natural killer cells to target HIV-1 persistence

Vinita R Joshi; Marcus Altfeld

doi:10.1097/COH.0000000000000848

Harnessing natural killer cells to target HIV-1 persistence

Standard

Harnessing natural killer cells to target HIV-1 persistence. / Joshi, Vinita R; Altfeld, Marcus.

in: CURR OPIN HIV AIDS, Jahrgang 19, Nr. 3, 01.05.2024, S. 141-149.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Joshi, VR & Altfeld, M 2024, 'Harnessing natural killer cells to target HIV-1 persistence', CURR OPIN HIV AIDS, Jg. 19, Nr. 3, S. 141-149. https://doi.org/10.1097/COH.0000000000000848

APA

Joshi, V. R., & Altfeld, M. (2024). Harnessing natural killer cells to target HIV-1 persistence. CURR OPIN HIV AIDS, 19(3), 141-149. https://doi.org/10.1097/COH.0000000000000848

Vancouver

Joshi VR, Altfeld M. Harnessing natural killer cells to target HIV-1 persistence. CURR OPIN HIV AIDS. 2024 Mai 1;19(3):141-149. https://doi.org/10.1097/COH.0000000000000848

Bibtex

@article{9ae33931da8a4e8ca73383cab023ca9d,

title = "Harnessing natural killer cells to target HIV-1 persistence",

abstract = "PURPOSE OF REVIEW: The purpose of this article is to review recent advances in the role of natural killer (NK) cells in approaches aimed at reducing the latent HIV-1 reservoir.RECENT FINDINGS: Multiple approaches to eliminate cells harboring latent HIV-1 are being explored, but have been met with limited success so far. Recent studies have highlighted the role of NK cells and their potential in HIV-1 cure efforts. Anti-HIV-1 NK cell function can be optimized by enhancing NK cell activation, antibody dependent cellular cytotoxicity, reversing inhibition of NK cells as well as by employing immunotherapeutic complexes to enable HIV-1 specificity of NK cells. While NK cells alone do not eliminate the HIV-1 reservoir, boosting NK cell function might complement other strategies involving T cell and B cell immunity towards an HIV-1 functional cure.SUMMARY: Numerous studies focusing on targeting latently HIV-1-infected cells have emphasized a potential role of NK cells in these strategies. Our review highlights recent advances in harnessing NK cells in conjunction with latency reversal agents and other immunomodulatory therapeutics to target HIV-1 persistence.",

author = "Joshi, {Vinita R} and Marcus Altfeld",

year = "2024",

month = may,

day = "1",

doi = "10.1097/COH.0000000000000848",

language = "English",

volume = "19",

pages = "141--149",

journal = "CURR OPIN HIV AIDS",

issn = "1746-630X",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

RIS

TY - JOUR

T1 - Harnessing natural killer cells to target HIV-1 persistence

AU - Joshi, Vinita R

AU - Altfeld, Marcus

PY - 2024/5/1

Y1 - 2024/5/1

N2 - PURPOSE OF REVIEW: The purpose of this article is to review recent advances in the role of natural killer (NK) cells in approaches aimed at reducing the latent HIV-1 reservoir.RECENT FINDINGS: Multiple approaches to eliminate cells harboring latent HIV-1 are being explored, but have been met with limited success so far. Recent studies have highlighted the role of NK cells and their potential in HIV-1 cure efforts. Anti-HIV-1 NK cell function can be optimized by enhancing NK cell activation, antibody dependent cellular cytotoxicity, reversing inhibition of NK cells as well as by employing immunotherapeutic complexes to enable HIV-1 specificity of NK cells. While NK cells alone do not eliminate the HIV-1 reservoir, boosting NK cell function might complement other strategies involving T cell and B cell immunity towards an HIV-1 functional cure.SUMMARY: Numerous studies focusing on targeting latently HIV-1-infected cells have emphasized a potential role of NK cells in these strategies. Our review highlights recent advances in harnessing NK cells in conjunction with latency reversal agents and other immunomodulatory therapeutics to target HIV-1 persistence.

AB - PURPOSE OF REVIEW: The purpose of this article is to review recent advances in the role of natural killer (NK) cells in approaches aimed at reducing the latent HIV-1 reservoir.RECENT FINDINGS: Multiple approaches to eliminate cells harboring latent HIV-1 are being explored, but have been met with limited success so far. Recent studies have highlighted the role of NK cells and their potential in HIV-1 cure efforts. Anti-HIV-1 NK cell function can be optimized by enhancing NK cell activation, antibody dependent cellular cytotoxicity, reversing inhibition of NK cells as well as by employing immunotherapeutic complexes to enable HIV-1 specificity of NK cells. While NK cells alone do not eliminate the HIV-1 reservoir, boosting NK cell function might complement other strategies involving T cell and B cell immunity towards an HIV-1 functional cure.SUMMARY: Numerous studies focusing on targeting latently HIV-1-infected cells have emphasized a potential role of NK cells in these strategies. Our review highlights recent advances in harnessing NK cells in conjunction with latency reversal agents and other immunomodulatory therapeutics to target HIV-1 persistence.

U2 - 10.1097/COH.0000000000000848

DO - 10.1097/COH.0000000000000848

M3 - SCORING: Journal article

C2 - 38457230

VL - 19

SP - 141

EP - 149

JO - CURR OPIN HIV AIDS

JF - CURR OPIN HIV AIDS

SN - 1746-630X

IS - 3

ER -