Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: A report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT

  • Anna Sureda
  • Paul A Carpenter
  • Andrea Bacigalupo
  • Vijaya Raj Bhatt
  • Josu de la Fuente
  • Aloysius Ho
  • Leslie Kean
  • Jong Wook Lee
  • Isabel Sánchez-Ortega
  • Bipin N Savani
  • Johannes Schetelig
  • Edward A Stadtmauer
  • Yoshiyuki Takahashi
  • Yoshiko Atsuta
  • John Koreth
  • Nicolaus Kröger
  • Per Ljungman
  • Shinichiro Okamoto
  • Uday Popat
  • Robert Soiffer
  • Heather E Stefanski
  • Mohamed A Kharfan-Dabaja

Abstract

Despite emergence of novel therapies to treat hematologic malignancies, allogeneic hematopoietic cell transplantation (allo-HCT) remains an essential treatment modality capable of curing these diseases. Allo-HCT has been also shown to be curative in benign hematologic disorders such as aplastic anemia, sickle cell disease, and thalassemia, among others. Recently, the American Society for Transplantation and Cellular Therapy (ASTCT) published standardized definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism. To attempt broader international consensus, a panel of adult and pediatric physician transplant experts was assembled from European Society for Blood and Marrow Transplantation (EBMT), ASTCT, the Center for International Blood and Marrow Transplant Research (CIBMTR), and Asia-Pacific Blood and Marrow Transplantation (APBMT). Consensus was defined as ≥70% of voting members strongly agreeing or somewhat agreeing with a definition. With few exceptions, there was a consensus to endorse the prior ASTCT definitions. Importantly, we revised existing EBMT and CIBMTR data collection forms to align with these harmonized definitions that will facilitate research and international collaboration among transplant researchers and across transplant registries.

Bibliografische Daten

OriginalspracheEnglisch
ISSN0268-3369
DOIs
StatusVeröffentlicht - 06.2024

Anmerkungen des Dekanats

© 2024. The Author(s).

PubMed 38443706