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Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction

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Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction. / Walter, Joan; Nestelberger, Thomas; Boeddinghaus, Jasper; Twerenbold, Raphael; Croton, Lukas; Badertscher, Patrick; Wildi, Karin; Wussler, Desiree; du Fay de Lavallaz, Jeanne; Mueller, Christian; APACE Investigators.

in: INT J CARDIOL, Jahrgang 292, 01.10.2019, S. 241-245.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Walter, J, Nestelberger, T, Boeddinghaus, J, Twerenbold, R, Croton, L, Badertscher, P, Wildi, K, Wussler, D, du Fay de Lavallaz, J, Mueller, C & APACE Investigators 2019, 'Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction', INT J CARDIOL, Jg. 292, S. 241-245. https://doi.org/10.1016/j.ijcard.2019.04.088

APA

Walter, J., Nestelberger, T., Boeddinghaus, J., Twerenbold, R., Croton, L., Badertscher, P., Wildi, K., Wussler, D., du Fay de Lavallaz, J., Mueller, C., & APACE Investigators (2019). Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction. INT J CARDIOL, 292, 241-245. https://doi.org/10.1016/j.ijcard.2019.04.088

Vancouver

Walter J, Nestelberger T, Boeddinghaus J, Twerenbold R, Croton L, Badertscher P et al. Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction. INT J CARDIOL. 2019 Okt 1;292:241-245. https://doi.org/10.1016/j.ijcard.2019.04.088

Bibtex

@article{b189708112224f0ab0dee4b6594f4810,
title = "Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction",
abstract = "BACKGROUND: To assess the prognostic performance of Growth differentiation factor-15 (GDF-15) concentrations in unselected patients presenting with suspected acute myocardial infarction (AMI) and adjudication based on high-sensitivity cardiac troponin (hs-cTn).METHODS AND RESULTS: In an ongoing prospective multicenter diagnostic study, consecutive patients presenting with suspected AMI to the emergency department and available GDF-15 and hs-cTnT concentrations were included. Adjudication of AMI was performed central by two independent cardiologists using all available clinical information including cardiac imaging and serial hs-cTn concentrations. Overall, 718 patients were included, with 23% (162/718) having an adjudicated diagnosis of AMI. The cumulative incidence of death within 2 years was 19% in patients with AMI (30 deaths in 162 patients) versus 5% in patients without AMI (25 deaths in 556 patients; P < 0.001). In AMI patients, GDF-15 provided an AUC of 0.89 (95% confidence interval [CI] 0.83-0.94) for 2-year death versus 0.55 (95% CI 0.44-0.66) for hs-cTnT (P < 0.001). A GDF-15 cutoff of ≤1560 ng/L predicted 2-year survival in 47% (76/162) of AMI patients and had 100% sensitivity (95% CI 88-100%) for 2-year death. In patients without AMI, GDF-15 provided an AUC of 0.83 (95% CI 0.76-0.89) versus 0.76 (95% CI 0.67-0.85) for hs-cTnT (P = 0.096). A GDF-15 cutoff of ≤886 ng/L predicted 2-year survival in 37% (203/556) of non-AMI patients and had 100% sensitivity (95% CI 86-100%) for 2-year death.CONCLUSIONS: GDF-15 concentrations at emergency department presentation have a high predictive accuracy for all-cause death in patients with suspected AMI and allow the identification of a large proportion of AMI patients with very low mortality risk.",
keywords = "Aged, Aged, 80 and over, Biomarkers/blood, Female, Follow-Up Studies, Growth Differentiation Factor 15/blood, Humans, Male, Middle Aged, Mortality/trends, Myocardial Infarction/blood, Prospective Studies",
author = "Joan Walter and Thomas Nestelberger and Jasper Boeddinghaus and Raphael Twerenbold and Lukas Croton and Patrick Badertscher and Karin Wildi and Desiree Wussler and {du Fay de Lavallaz}, Jeanne and Christian Mueller and {APACE Investigators}",
note = "Copyright {\textcopyright} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
month = oct,
day = "1",
doi = "10.1016/j.ijcard.2019.04.088",
language = "English",
volume = "292",
pages = "241--245",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction

AU - Walter, Joan

AU - Nestelberger, Thomas

AU - Boeddinghaus, Jasper

AU - Twerenbold, Raphael

AU - Croton, Lukas

AU - Badertscher, Patrick

AU - Wildi, Karin

AU - Wussler, Desiree

AU - du Fay de Lavallaz, Jeanne

AU - Mueller, Christian

AU - APACE Investigators

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - BACKGROUND: To assess the prognostic performance of Growth differentiation factor-15 (GDF-15) concentrations in unselected patients presenting with suspected acute myocardial infarction (AMI) and adjudication based on high-sensitivity cardiac troponin (hs-cTn).METHODS AND RESULTS: In an ongoing prospective multicenter diagnostic study, consecutive patients presenting with suspected AMI to the emergency department and available GDF-15 and hs-cTnT concentrations were included. Adjudication of AMI was performed central by two independent cardiologists using all available clinical information including cardiac imaging and serial hs-cTn concentrations. Overall, 718 patients were included, with 23% (162/718) having an adjudicated diagnosis of AMI. The cumulative incidence of death within 2 years was 19% in patients with AMI (30 deaths in 162 patients) versus 5% in patients without AMI (25 deaths in 556 patients; P < 0.001). In AMI patients, GDF-15 provided an AUC of 0.89 (95% confidence interval [CI] 0.83-0.94) for 2-year death versus 0.55 (95% CI 0.44-0.66) for hs-cTnT (P < 0.001). A GDF-15 cutoff of ≤1560 ng/L predicted 2-year survival in 47% (76/162) of AMI patients and had 100% sensitivity (95% CI 88-100%) for 2-year death. In patients without AMI, GDF-15 provided an AUC of 0.83 (95% CI 0.76-0.89) versus 0.76 (95% CI 0.67-0.85) for hs-cTnT (P = 0.096). A GDF-15 cutoff of ≤886 ng/L predicted 2-year survival in 37% (203/556) of non-AMI patients and had 100% sensitivity (95% CI 86-100%) for 2-year death.CONCLUSIONS: GDF-15 concentrations at emergency department presentation have a high predictive accuracy for all-cause death in patients with suspected AMI and allow the identification of a large proportion of AMI patients with very low mortality risk.

AB - BACKGROUND: To assess the prognostic performance of Growth differentiation factor-15 (GDF-15) concentrations in unselected patients presenting with suspected acute myocardial infarction (AMI) and adjudication based on high-sensitivity cardiac troponin (hs-cTn).METHODS AND RESULTS: In an ongoing prospective multicenter diagnostic study, consecutive patients presenting with suspected AMI to the emergency department and available GDF-15 and hs-cTnT concentrations were included. Adjudication of AMI was performed central by two independent cardiologists using all available clinical information including cardiac imaging and serial hs-cTn concentrations. Overall, 718 patients were included, with 23% (162/718) having an adjudicated diagnosis of AMI. The cumulative incidence of death within 2 years was 19% in patients with AMI (30 deaths in 162 patients) versus 5% in patients without AMI (25 deaths in 556 patients; P < 0.001). In AMI patients, GDF-15 provided an AUC of 0.89 (95% confidence interval [CI] 0.83-0.94) for 2-year death versus 0.55 (95% CI 0.44-0.66) for hs-cTnT (P < 0.001). A GDF-15 cutoff of ≤1560 ng/L predicted 2-year survival in 47% (76/162) of AMI patients and had 100% sensitivity (95% CI 88-100%) for 2-year death. In patients without AMI, GDF-15 provided an AUC of 0.83 (95% CI 0.76-0.89) versus 0.76 (95% CI 0.67-0.85) for hs-cTnT (P = 0.096). A GDF-15 cutoff of ≤886 ng/L predicted 2-year survival in 37% (203/556) of non-AMI patients and had 100% sensitivity (95% CI 86-100%) for 2-year death.CONCLUSIONS: GDF-15 concentrations at emergency department presentation have a high predictive accuracy for all-cause death in patients with suspected AMI and allow the identification of a large proportion of AMI patients with very low mortality risk.

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers/blood

KW - Female

KW - Follow-Up Studies

KW - Growth Differentiation Factor 15/blood

KW - Humans

KW - Male

KW - Middle Aged

KW - Mortality/trends

KW - Myocardial Infarction/blood

KW - Prospective Studies

U2 - 10.1016/j.ijcard.2019.04.088

DO - 10.1016/j.ijcard.2019.04.088

M3 - SCORING: Journal article

C2 - 31174919

VL - 292

SP - 241

EP - 245

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -