Grasping multiple sclerosis
Standard
Grasping multiple sclerosis : do quantitative motor assessments provide a link between structure and function? / Reilmann, R; Holtbernd, F; Bachmann, R; Mohammadi, S; Ringelstein, E B; Deppe, M.
in: J NEUROL, Jahrgang 260, Nr. 2, 01.02.2013, S. 407-14.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Grasping multiple sclerosis
T2 - do quantitative motor assessments provide a link between structure and function?
AU - Reilmann, R
AU - Holtbernd, F
AU - Bachmann, R
AU - Mohammadi, S
AU - Ringelstein, E B
AU - Deppe, M
PY - 2013/2/1
Y1 - 2013/2/1
N2 - Motor disability in MS is commonly assessed by the Expanded Disability Status Scale (EDSS). Categorical rating scales are limited by subjective error and inter-rater variability. Therefore, objective and quantitative measures of motor disability may be useful to supplement the EDSS in the setting of clinical trials. It was previously shown that grip-force-variability (GFV) is increased in MS. We hypothesized that GFV may be an objective measure of motor disability in MS. To investigate whether the increase in GFV in MS is correlated to the clinical disability as assessed by the EDSS and to microstructural changes in the brain as assessed by diffusion tensor imaging, GFV was recorded in a grasping and lifting task in 27 MS patients and 23 controls using a grip-device equipped with a force transducer. The EDSS was assessed by neurologists experienced in MS. Patients underwent diffusion tensor imaging at 3T to assess the fractional anisotropy (FA) of the cerebral white matter as a measure of microstructural brain integrity. GFV was increased in MS and correlated to changes in the FA of white matter in the vicinity of the somatosensory and visual cortex. GFV also correlated with the EDSS. GFV may be a useful objective measure of motor dysfunction in MS linked to disability and structural changes in the brain. Our data suggests that GFV should be further explored as an objective measure of motor dysfunction in MS. It could supplement the EDSS, e.g., in proof of concept studies.
AB - Motor disability in MS is commonly assessed by the Expanded Disability Status Scale (EDSS). Categorical rating scales are limited by subjective error and inter-rater variability. Therefore, objective and quantitative measures of motor disability may be useful to supplement the EDSS in the setting of clinical trials. It was previously shown that grip-force-variability (GFV) is increased in MS. We hypothesized that GFV may be an objective measure of motor disability in MS. To investigate whether the increase in GFV in MS is correlated to the clinical disability as assessed by the EDSS and to microstructural changes in the brain as assessed by diffusion tensor imaging, GFV was recorded in a grasping and lifting task in 27 MS patients and 23 controls using a grip-device equipped with a force transducer. The EDSS was assessed by neurologists experienced in MS. Patients underwent diffusion tensor imaging at 3T to assess the fractional anisotropy (FA) of the cerebral white matter as a measure of microstructural brain integrity. GFV was increased in MS and correlated to changes in the FA of white matter in the vicinity of the somatosensory and visual cortex. GFV also correlated with the EDSS. GFV may be a useful objective measure of motor dysfunction in MS linked to disability and structural changes in the brain. Our data suggests that GFV should be further explored as an objective measure of motor dysfunction in MS. It could supplement the EDSS, e.g., in proof of concept studies.
KW - Adult
KW - Anisotropy
KW - Diffusion Magnetic Resonance Imaging
KW - Disability Evaluation
KW - Disabled Persons
KW - Female
KW - Hand Strength
KW - Humans
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis
KW - Nerve Fibers, Myelinated
KW - Statistics as Topic
KW - Young Adult
U2 - 10.1007/s00415-012-6639-7
DO - 10.1007/s00415-012-6639-7
M3 - SCORING: Journal article
C2 - 22872165
VL - 260
SP - 407
EP - 414
JO - J NEUROL
JF - J NEUROL
SN - 0340-5354
IS - 2
ER -