Go or stop? Divergent roles of Reelin in radial neuronal migration.
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Go or stop? Divergent roles of Reelin in radial neuronal migration. / Zhao, Shanting; Frotscher, Michael.
in: NEUROSCIENTIST, Jahrgang 16, Nr. 4, 4, 2010, S. 421-434.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Go or stop? Divergent roles of Reelin in radial neuronal migration.
AU - Zhao, Shanting
AU - Frotscher, Michael
PY - 2010
Y1 - 2010
N2 - Neuronal migration is an essential step of brain development and is controlled by a variety of cellular proteins and extracellular matrix molecules. Reelin, an extracellular matrix protein, is required for neuronal migration. Over the past 10 years, the Reelin signaling cascade has been studied intensively. However, the role of Reelin in neuronal migration has remained unclear. Different Reelin fragments and different Reelin receptors suggest multiple functions of Reelin. In this review, the authors focus on Reelin effects on the actin cytoskeleton of migrating neurons.
AB - Neuronal migration is an essential step of brain development and is controlled by a variety of cellular proteins and extracellular matrix molecules. Reelin, an extracellular matrix protein, is required for neuronal migration. Over the past 10 years, the Reelin signaling cascade has been studied intensively. However, the role of Reelin in neuronal migration has remained unclear. Different Reelin fragments and different Reelin receptors suggest multiple functions of Reelin. In this review, the authors focus on Reelin effects on the actin cytoskeleton of migrating neurons.
KW - Animals
KW - Mice
KW - Cell Movement physiology
KW - Neurons physiology
KW - Brain embryology
KW - Cell Adhesion Molecules, Neuronal physiology
KW - Cytoskeleton physiology
KW - Extracellular Matrix Proteins physiology
KW - Nerve Tissue Proteins physiology
KW - Serine Endopeptidases physiology
KW - Animals
KW - Mice
KW - Cell Movement physiology
KW - Neurons physiology
KW - Brain embryology
KW - Cell Adhesion Molecules, Neuronal physiology
KW - Cytoskeleton physiology
KW - Extracellular Matrix Proteins physiology
KW - Nerve Tissue Proteins physiology
KW - Serine Endopeptidases physiology
M3 - SCORING: Zeitschriftenaufsatz
VL - 16
SP - 421
EP - 434
JO - NEUROSCIENTIST
JF - NEUROSCIENTIST
SN - 1073-8584
IS - 4
M1 - 4
ER -