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Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases.

Standard

Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases. / Dahl, Anka; Berlin, Anke; Brunner, Georg; Schulze, Hans-Joachim; Moll, Ingrid; Pfüller, Uwe; Wagener, Christoph; Schachner, Melitta; Altevogt, Peter; Schumacher, Udo.

in: CANCER LETT, Jahrgang 248, Nr. 1, 1, 2007, S. 68-80.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dahl, A, Berlin, A, Brunner, G, Schulze, H-J, Moll, I, Pfüller, U, Wagener, C, Schachner, M, Altevogt, P & Schumacher, U 2007, 'Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases.', CANCER LETT, Jg. 248, Nr. 1, 1, S. 68-80. <http://www.ncbi.nlm.nih.gov/pubmed/16822608?dopt=Citation>

APA

Dahl, A., Berlin, A., Brunner, G., Schulze, H-J., Moll, I., Pfüller, U., Wagener, C., Schachner, M., Altevogt, P., & Schumacher, U. (2007). Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases. CANCER LETT, 248(1), 68-80. [1]. http://www.ncbi.nlm.nih.gov/pubmed/16822608?dopt=Citation

Vancouver

Dahl A, Berlin A, Brunner G, Schulze H-J, Moll I, Pfüller U et al. Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases. CANCER LETT. 2007;248(1):68-80. 1.

Bibtex

@article{ff4c636f98934b08938247eb82ffdc27,
title = "Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases.",
abstract = "Aiming at more precise detection of melanoma cells in sentinel lymph nodes and better understanding of the mechanisms underlying metastatic spread, expression of L1, CEACAM1, and binding of the lectins HPA, ML-I and PNA, was assessed in benign nevi (n=12), primary melanomas (PTs: n=67), their corresponding sentinel lymph nodes (SLNs: n=40), and distant metastases (DMs: n=35). Sensitivity and specificity of CEACAM1 (95-97%; 66%) and L1 (90-93%; 100%) exceeded that of the standard markers MelanA, S100, and HMB45 in single marker use. Lectin binding was found in PTs and DMs (HPA: 69% and 77%; ML-I: 82% and 77%, respectively), but rarely in SLNMs (HPA: 20%, ML-I: 20%, PNA: 5%, respectively). The highly specific and sensitive L1-11A against L1 and 4D1/C2 against CEACAM1 antibodies are a worthy completion to standard antibody panels for diagnosis of melanoma cells. Both CAMs seem to be functionally involved in lymphatic and haematogenous spread, and are thus promising target molecules for immunotoxins.",
author = "Anka Dahl and Anke Berlin and Georg Brunner and Hans-Joachim Schulze and Ingrid Moll and Uwe Pf{\"u}ller and Christoph Wagener and Melitta Schachner and Peter Altevogt and Udo Schumacher",
year = "2007",
language = "Deutsch",
volume = "248",
pages = "68--80",
journal = "CANCER LETT",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases.

AU - Dahl, Anka

AU - Berlin, Anke

AU - Brunner, Georg

AU - Schulze, Hans-Joachim

AU - Moll, Ingrid

AU - Pfüller, Uwe

AU - Wagener, Christoph

AU - Schachner, Melitta

AU - Altevogt, Peter

AU - Schumacher, Udo

PY - 2007

Y1 - 2007

N2 - Aiming at more precise detection of melanoma cells in sentinel lymph nodes and better understanding of the mechanisms underlying metastatic spread, expression of L1, CEACAM1, and binding of the lectins HPA, ML-I and PNA, was assessed in benign nevi (n=12), primary melanomas (PTs: n=67), their corresponding sentinel lymph nodes (SLNs: n=40), and distant metastases (DMs: n=35). Sensitivity and specificity of CEACAM1 (95-97%; 66%) and L1 (90-93%; 100%) exceeded that of the standard markers MelanA, S100, and HMB45 in single marker use. Lectin binding was found in PTs and DMs (HPA: 69% and 77%; ML-I: 82% and 77%, respectively), but rarely in SLNMs (HPA: 20%, ML-I: 20%, PNA: 5%, respectively). The highly specific and sensitive L1-11A against L1 and 4D1/C2 against CEACAM1 antibodies are a worthy completion to standard antibody panels for diagnosis of melanoma cells. Both CAMs seem to be functionally involved in lymphatic and haematogenous spread, and are thus promising target molecules for immunotoxins.

AB - Aiming at more precise detection of melanoma cells in sentinel lymph nodes and better understanding of the mechanisms underlying metastatic spread, expression of L1, CEACAM1, and binding of the lectins HPA, ML-I and PNA, was assessed in benign nevi (n=12), primary melanomas (PTs: n=67), their corresponding sentinel lymph nodes (SLNs: n=40), and distant metastases (DMs: n=35). Sensitivity and specificity of CEACAM1 (95-97%; 66%) and L1 (90-93%; 100%) exceeded that of the standard markers MelanA, S100, and HMB45 in single marker use. Lectin binding was found in PTs and DMs (HPA: 69% and 77%; ML-I: 82% and 77%, respectively), but rarely in SLNMs (HPA: 20%, ML-I: 20%, PNA: 5%, respectively). The highly specific and sensitive L1-11A against L1 and 4D1/C2 against CEACAM1 antibodies are a worthy completion to standard antibody panels for diagnosis of melanoma cells. Both CAMs seem to be functionally involved in lymphatic and haematogenous spread, and are thus promising target molecules for immunotoxins.

M3 - SCORING: Zeitschriftenaufsatz

VL - 248

SP - 68

EP - 80

JO - CANCER LETT

JF - CANCER LETT

SN - 0304-3835

IS - 1

M1 - 1

ER -