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Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy

Standard

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy. / Engler, Jan Broder; Kursawe, Nina; Solano, María Emilia; Patas, Konstantinos; Wehrmann, Sabine; Heckmann, Nina; Lühder, Fred; Reichardt, Holger M; Arck, Petra Clara; Gold, Stefan M; Friese, Manuel A.

in: P NATL ACAD SCI USA, Jahrgang 114, Nr. 2, 10.01.2017, S. E181-E190.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Engler, JB, Kursawe, N, Solano, ME, Patas, K, Wehrmann, S, Heckmann, N, Lühder, F, Reichardt, HM, Arck, PC, Gold, SM & Friese, MA 2017, 'Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy', P NATL ACAD SCI USA, Jg. 114, Nr. 2, S. E181-E190. https://doi.org/10.1073/pnas.1617115114

APA

Engler, J. B., Kursawe, N., Solano, M. E., Patas, K., Wehrmann, S., Heckmann, N., Lühder, F., Reichardt, H. M., Arck, P. C., Gold, S. M., & Friese, M. A. (2017). Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy. P NATL ACAD SCI USA, 114(2), E181-E190. https://doi.org/10.1073/pnas.1617115114

Vancouver

Engler JB, Kursawe N, Solano ME, Patas K, Wehrmann S, Heckmann N et al. Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy. P NATL ACAD SCI USA. 2017 Jan 10;114(2):E181-E190. https://doi.org/10.1073/pnas.1617115114

Bibtex

@article{f92df68f166a40efb6be0a90855cf2c6,
title = "Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy",
abstract = "Pregnancy is one of the strongest inducers of immunological tolerance. Disease activity of many autoimmune diseases including multiple sclerosis (MS) is temporarily suppressed by pregnancy, but little is known about the underlying molecular mechanisms. Here, we investigated the endocrine regulation of conventional and regulatory T cells (Tregs) during reproduction. In vitro, we found the pregnancy hormone progesterone to robustly increase Treg frequencies via promiscuous binding to the glucocorticoid receptor (GR) in T cells. In vivo, T-cell-specific GR deletion in pregnant animals undergoing experimental autoimmune encephalomyelitis (EAE), the animal model of MS, resulted in a reduced Treg increase and a selective loss of pregnancy-induced protection, whereas reproductive success was unaffected. Our data imply that steroid hormones can shift the immunological balance in favor of Tregs via differential engagement of the GR in T cells. This newly defined mechanism confers protection from autoimmunity during pregnancy and represents a potential target for future therapy.",
author = "Engler, {Jan Broder} and Nina Kursawe and Solano, {Mar{\'i}a Emilia} and Konstantinos Patas and Sabine Wehrmann and Nina Heckmann and Fred L{\"u}hder and Reichardt, {Holger M} and Arck, {Petra Clara} and Gold, {Stefan M} and Friese, {Manuel A}",
year = "2017",
month = jan,
day = "10",
doi = "10.1073/pnas.1617115114",
language = "English",
volume = "114",
pages = "E181--E190",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "2",

}

RIS

TY - JOUR

T1 - Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy

AU - Engler, Jan Broder

AU - Kursawe, Nina

AU - Solano, María Emilia

AU - Patas, Konstantinos

AU - Wehrmann, Sabine

AU - Heckmann, Nina

AU - Lühder, Fred

AU - Reichardt, Holger M

AU - Arck, Petra Clara

AU - Gold, Stefan M

AU - Friese, Manuel A

PY - 2017/1/10

Y1 - 2017/1/10

N2 - Pregnancy is one of the strongest inducers of immunological tolerance. Disease activity of many autoimmune diseases including multiple sclerosis (MS) is temporarily suppressed by pregnancy, but little is known about the underlying molecular mechanisms. Here, we investigated the endocrine regulation of conventional and regulatory T cells (Tregs) during reproduction. In vitro, we found the pregnancy hormone progesterone to robustly increase Treg frequencies via promiscuous binding to the glucocorticoid receptor (GR) in T cells. In vivo, T-cell-specific GR deletion in pregnant animals undergoing experimental autoimmune encephalomyelitis (EAE), the animal model of MS, resulted in a reduced Treg increase and a selective loss of pregnancy-induced protection, whereas reproductive success was unaffected. Our data imply that steroid hormones can shift the immunological balance in favor of Tregs via differential engagement of the GR in T cells. This newly defined mechanism confers protection from autoimmunity during pregnancy and represents a potential target for future therapy.

AB - Pregnancy is one of the strongest inducers of immunological tolerance. Disease activity of many autoimmune diseases including multiple sclerosis (MS) is temporarily suppressed by pregnancy, but little is known about the underlying molecular mechanisms. Here, we investigated the endocrine regulation of conventional and regulatory T cells (Tregs) during reproduction. In vitro, we found the pregnancy hormone progesterone to robustly increase Treg frequencies via promiscuous binding to the glucocorticoid receptor (GR) in T cells. In vivo, T-cell-specific GR deletion in pregnant animals undergoing experimental autoimmune encephalomyelitis (EAE), the animal model of MS, resulted in a reduced Treg increase and a selective loss of pregnancy-induced protection, whereas reproductive success was unaffected. Our data imply that steroid hormones can shift the immunological balance in favor of Tregs via differential engagement of the GR in T cells. This newly defined mechanism confers protection from autoimmunity during pregnancy and represents a potential target for future therapy.

U2 - 10.1073/pnas.1617115114

DO - 10.1073/pnas.1617115114

M3 - SCORING: Journal article

C2 - 28049829

VL - 114

SP - E181-E190

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 2

ER -