Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility.

  • Frédéric Chalmel
  • Aurélie Lardenois
  • Bertrand Evrard
  • Romain Mathieu
  • Caroline Feig
  • Philippe Demougin
  • Alexandre Gattiker
  • Wolfgang Schulze
  • Bernard Jégou
  • Christiane Kirchhoff
  • Michael Primig

Abstract

Mammalian spermatogenesis is a process that involves a complex expression program in both somatic and germ cells present in the male gonad. A number of studies have attempted to define the transcriptome of male meiosis and gametogenesis in rodents and primates. Few human transcripts, however, have been associated with testicular somatic cells and germ cells at different post-natal developmental stages and little is known about their level of germline-specificity compared with non-testicular tissues.

Bibliografische Daten

OriginalspracheEnglisch
Aufsatznummer11
ISSN0268-1161
StatusVeröffentlicht - 2012
pubmed 22926843