Glioma infiltration of the corpus callosum: early signs detected by DTI
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Glioma infiltration of the corpus callosum: early signs detected by DTI. / Kallenberg, K; Goldmann, T; Menke, J; Strik, H; Bock, H C; Stockhammer, F; Buhk, J H; Frahm, J; Dechent, P; Knauth, M.
in: J NEURO-ONCOL, Jahrgang 112, Nr. 2, 01.04.2013, S. 217-22.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Glioma infiltration of the corpus callosum: early signs detected by DTI
AU - Kallenberg, K
AU - Goldmann, T
AU - Menke, J
AU - Strik, H
AU - Bock, H C
AU - Stockhammer, F
AU - Buhk, J H
AU - Frahm, J
AU - Dechent, P
AU - Knauth, M
PY - 2013/4/1
Y1 - 2013/4/1
N2 - The most frequent primary brain tumors, anaplastic astrocytomas (AA) and glioblastomas (GBM): tend to invasion of the surrounding brain. Histopathological studies found malignant cells in macroscopically unsuspicious brain parenchyma remote from the primary tumor, even affecting the contralateral hemisphere. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is suspected. The purpose of this study was to investigate the value of DTI as a possible instrument of depicting evidence of tumor invasion into the corpus callosum (CC). Preoperatively, 31 patients with high-grade brain tumors (8 AA and 23 GBM) were examined by MRI at 3 T, applying a high-resolution diffusion tensor imaging (DTI) sequence. ADC- and FA-values were analyzed in the tumor-associated area of the CC as identified by fiber tracking, and were compared to matched healthy controls. In (MR-)morphologically normal appearing CC the ADC values were elevated in the tumor patients (n = 22; 0.978 × 10(-3) mm²/s) compared to matched controls (0.917 × 10(-3) mm²/s, p < 0.05), and the corresponding relative FA was reduced (rFA: 88 %, p < 0.01). The effect was pronounced in case of affection of the CC visible on MRI (n = 9; 0.978 × 10(-3) mm²/s, p < 0.05; rFA: 72 %, p < 0.01). Changes in diffusivity and anisotropy in the CC can be interpreted as an indicator of tumor spread into the contralateral hemisphere not visible on conventional MRI.
AB - The most frequent primary brain tumors, anaplastic astrocytomas (AA) and glioblastomas (GBM): tend to invasion of the surrounding brain. Histopathological studies found malignant cells in macroscopically unsuspicious brain parenchyma remote from the primary tumor, even affecting the contralateral hemisphere. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is suspected. The purpose of this study was to investigate the value of DTI as a possible instrument of depicting evidence of tumor invasion into the corpus callosum (CC). Preoperatively, 31 patients with high-grade brain tumors (8 AA and 23 GBM) were examined by MRI at 3 T, applying a high-resolution diffusion tensor imaging (DTI) sequence. ADC- and FA-values were analyzed in the tumor-associated area of the CC as identified by fiber tracking, and were compared to matched healthy controls. In (MR-)morphologically normal appearing CC the ADC values were elevated in the tumor patients (n = 22; 0.978 × 10(-3) mm²/s) compared to matched controls (0.917 × 10(-3) mm²/s, p < 0.05), and the corresponding relative FA was reduced (rFA: 88 %, p < 0.01). The effect was pronounced in case of affection of the CC visible on MRI (n = 9; 0.978 × 10(-3) mm²/s, p < 0.05; rFA: 72 %, p < 0.01). Changes in diffusivity and anisotropy in the CC can be interpreted as an indicator of tumor spread into the contralateral hemisphere not visible on conventional MRI.
KW - Adult
KW - Aged
KW - Anisotropy
KW - Brain Neoplasms
KW - Case-Control Studies
KW - Corpus Callosum
KW - Diffusion Magnetic Resonance Imaging
KW - Diffusion Tensor Imaging
KW - Early Detection of Cancer
KW - Female
KW - Follow-Up Studies
KW - Glioma
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Male
KW - Middle Aged
KW - Neoplasm Grading
KW - Prognosis
KW - Survival Rate
KW - Young Adult
U2 - 10.1007/s11060-013-1049-y
DO - 10.1007/s11060-013-1049-y
M3 - SCORING: Journal article
C2 - 23344787
VL - 112
SP - 217
EP - 222
JO - J NEURO-ONCOL
JF - J NEURO-ONCOL
SN - 0167-594X
IS - 2
ER -