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Genomic instability in Gadd45a-deficient mice

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Genomic instability in Gadd45a-deficient mice. / Hollander, M C; Sheikh, M S; Bulavin, D V; Lundgren, K; Augeri-Henmueller, L; Shehee, R; Molinaro, T A; Kim, K E; Tolosa, E; Ashwell, J D; Rosenberg, M P; Zhan, Q; Fernández-Salguero, P M; Morgan, W F; Deng, C X; Fornace, A J.

in: NAT GENET, Jahrgang 23, Nr. 2, 01.10.1999, S. 176-84.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hollander, MC, Sheikh, MS, Bulavin, DV, Lundgren, K, Augeri-Henmueller, L, Shehee, R, Molinaro, TA, Kim, KE, Tolosa, E, Ashwell, JD, Rosenberg, MP, Zhan, Q, Fernández-Salguero, PM, Morgan, WF, Deng, CX & Fornace, AJ 1999, 'Genomic instability in Gadd45a-deficient mice', NAT GENET, Jg. 23, Nr. 2, S. 176-84. https://doi.org/10.1038/13802

APA

Hollander, M. C., Sheikh, M. S., Bulavin, D. V., Lundgren, K., Augeri-Henmueller, L., Shehee, R., Molinaro, T. A., Kim, K. E., Tolosa, E., Ashwell, J. D., Rosenberg, M. P., Zhan, Q., Fernández-Salguero, P. M., Morgan, W. F., Deng, C. X., & Fornace, A. J. (1999). Genomic instability in Gadd45a-deficient mice. NAT GENET, 23(2), 176-84. https://doi.org/10.1038/13802

Vancouver

Hollander MC, Sheikh MS, Bulavin DV, Lundgren K, Augeri-Henmueller L, Shehee R et al. Genomic instability in Gadd45a-deficient mice. NAT GENET. 1999 Okt 1;23(2):176-84. https://doi.org/10.1038/13802

Bibtex

@article{ee4288c5935548879c1058f988007fe2,
title = "Genomic instability in Gadd45a-deficient mice",
abstract = "Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes characteristic of p53-deficient mice, including genomic instability, increased radiation carcinogenesis and a low frequency of exencephaly. Genomic instability was exemplified by aneuploidy, chromosome aberrations, gene amplification and centrosome amplification, and was accompanied by abnormalities in mitosis, cytokinesis and growth control. Unequal segregation of chromosomes due to multiple spindle poles during mitosis occurred in several Gadd45a -/- cell lineages and may contribute to the aneuploidy. Our results indicate that Gadd45a is one component of the p53 pathway that contributes to the maintenance of genomic stability.",
keywords = "Animals, Apoptosis, Cell Aging, Cell Cycle, Cell Division, Cell Transformation, Neoplastic, Centrosome, Embryo, Mammalian, Female, Fibroblasts, G1 Phase, Gamma Rays, Gene Deletion, Genes, ras, Intracellular Signaling Peptides and Proteins, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neoplasms, Phenotype, Proteins, Thymus Hyperplasia",
author = "Hollander, {M C} and Sheikh, {M S} and Bulavin, {D V} and K Lundgren and L Augeri-Henmueller and R Shehee and Molinaro, {T A} and Kim, {K E} and E Tolosa and Ashwell, {J D} and Rosenberg, {M P} and Q Zhan and Fern{\'a}ndez-Salguero, {P M} and Morgan, {W F} and Deng, {C X} and Fornace, {A J}",
year = "1999",
month = oct,
day = "1",
doi = "10.1038/13802",
language = "English",
volume = "23",
pages = "176--84",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Genomic instability in Gadd45a-deficient mice

AU - Hollander, M C

AU - Sheikh, M S

AU - Bulavin, D V

AU - Lundgren, K

AU - Augeri-Henmueller, L

AU - Shehee, R

AU - Molinaro, T A

AU - Kim, K E

AU - Tolosa, E

AU - Ashwell, J D

AU - Rosenberg, M P

AU - Zhan, Q

AU - Fernández-Salguero, P M

AU - Morgan, W F

AU - Deng, C X

AU - Fornace, A J

PY - 1999/10/1

Y1 - 1999/10/1

N2 - Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes characteristic of p53-deficient mice, including genomic instability, increased radiation carcinogenesis and a low frequency of exencephaly. Genomic instability was exemplified by aneuploidy, chromosome aberrations, gene amplification and centrosome amplification, and was accompanied by abnormalities in mitosis, cytokinesis and growth control. Unequal segregation of chromosomes due to multiple spindle poles during mitosis occurred in several Gadd45a -/- cell lineages and may contribute to the aneuploidy. Our results indicate that Gadd45a is one component of the p53 pathway that contributes to the maintenance of genomic stability.

AB - Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes characteristic of p53-deficient mice, including genomic instability, increased radiation carcinogenesis and a low frequency of exencephaly. Genomic instability was exemplified by aneuploidy, chromosome aberrations, gene amplification and centrosome amplification, and was accompanied by abnormalities in mitosis, cytokinesis and growth control. Unequal segregation of chromosomes due to multiple spindle poles during mitosis occurred in several Gadd45a -/- cell lineages and may contribute to the aneuploidy. Our results indicate that Gadd45a is one component of the p53 pathway that contributes to the maintenance of genomic stability.

KW - Animals

KW - Apoptosis

KW - Cell Aging

KW - Cell Cycle

KW - Cell Division

KW - Cell Transformation, Neoplastic

KW - Centrosome

KW - Embryo, Mammalian

KW - Female

KW - Fibroblasts

KW - G1 Phase

KW - Gamma Rays

KW - Gene Deletion

KW - Genes, ras

KW - Intracellular Signaling Peptides and Proteins

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Neoplasms

KW - Phenotype

KW - Proteins

KW - Thymus Hyperplasia

U2 - 10.1038/13802

DO - 10.1038/13802

M3 - SCORING: Journal article

C2 - 10508513

VL - 23

SP - 176

EP - 184

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 2

ER -