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Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

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Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility. / Corradi, Chiara; Gentiluomo, Manuel; Gajdán, László; Cavestro, Giulia Martina; Kreivenaite, Edita; Di Franco, Gregorio; Sperti, Cosimo; Giaccherini, Matteo; Petrone, Maria Chiara; Tavano, Francesca; Gioffreda, Domenica; Morelli, Luca; Soucek, Pavel; Andriulli, Angelo; Izbicki, Jakob R; Napoli, Niccolò; Małecka-Panas, Ewa; Hegyi, Péter; Neoptolemos, John P; Landi, Stefano; Vashist, Yogesh; Pasquali, Claudio; Lu, Ye; Cervena, Klara; Theodoropoulos, George E; Moz, Stefania; Capurso, Gabriele; Strobel, Oliver; Carrara, Silvia; Hackert, Thilo; Hlavac, Viktor; Archibugi, Livia; Oliverius, Martin; Vanella, Giuseppe; Vodicka, Pavel; Arcidiacono, Paolo Giorgio; Pezzilli, Raffaele; Milanetto, Anna Caterina; Lawlor, Rita T; Ivanauskas, Audrius; Szentesi, Andrea; Kupcinskas, Juozas; Testoni, Sabrina G G; Lovecek, Martin; Nentwich, Michael; Gazouli, Maria; Luchini, Claudio; Zuppardo, Raffaella Alessia; Darvasi, Erika; Brenner, Hermann; Gheorghe, Cristian; Jamroziak, Krzysztof; Canzian, Federico; Campa, Daniele.

in: INT J CANCER, Jahrgang 148, Nr. 11, 01.06.2021, S. 2779-2788.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Corradi, C, Gentiluomo, M, Gajdán, L, Cavestro, GM, Kreivenaite, E, Di Franco, G, Sperti, C, Giaccherini, M, Petrone, MC, Tavano, F, Gioffreda, D, Morelli, L, Soucek, P, Andriulli, A, Izbicki, JR, Napoli, N, Małecka-Panas, E, Hegyi, P, Neoptolemos, JP, Landi, S, Vashist, Y, Pasquali, C, Lu, Y, Cervena, K, Theodoropoulos, GE, Moz, S, Capurso, G, Strobel, O, Carrara, S, Hackert, T, Hlavac, V, Archibugi, L, Oliverius, M, Vanella, G, Vodicka, P, Arcidiacono, PG, Pezzilli, R, Milanetto, AC, Lawlor, RT, Ivanauskas, A, Szentesi, A, Kupcinskas, J, Testoni, SGG, Lovecek, M, Nentwich, M, Gazouli, M, Luchini, C, Zuppardo, RA, Darvasi, E, Brenner, H, Gheorghe, C, Jamroziak, K, Canzian, F & Campa, D 2021, 'Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility', INT J CANCER, Jg. 148, Nr. 11, S. 2779-2788. https://doi.org/10.1002/ijc.33475

APA

Corradi, C., Gentiluomo, M., Gajdán, L., Cavestro, G. M., Kreivenaite, E., Di Franco, G., Sperti, C., Giaccherini, M., Petrone, M. C., Tavano, F., Gioffreda, D., Morelli, L., Soucek, P., Andriulli, A., Izbicki, J. R., Napoli, N., Małecka-Panas, E., Hegyi, P., Neoptolemos, J. P., ... Campa, D. (2021). Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility. INT J CANCER, 148(11), 2779-2788. https://doi.org/10.1002/ijc.33475

Vancouver

Corradi C, Gentiluomo M, Gajdán L, Cavestro GM, Kreivenaite E, Di Franco G et al. Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility. INT J CANCER. 2021 Jun 1;148(11):2779-2788. https://doi.org/10.1002/ijc.33475

Bibtex

@article{2cd0cefdd30e4a2c8f6071e7cda31295,
title = "Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 × 10-9 ). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.",
author = "Chiara Corradi and Manuel Gentiluomo and L{\'a}szl{\'o} Gajd{\'a}n and Cavestro, {Giulia Martina} and Edita Kreivenaite and {Di Franco}, Gregorio and Cosimo Sperti and Matteo Giaccherini and Petrone, {Maria Chiara} and Francesca Tavano and Domenica Gioffreda and Luca Morelli and Pavel Soucek and Angelo Andriulli and Izbicki, {Jakob R} and Niccol{\`o} Napoli and Ewa Ma{\l}ecka-Panas and P{\'e}ter Hegyi and Neoptolemos, {John P} and Stefano Landi and Yogesh Vashist and Claudio Pasquali and Ye Lu and Klara Cervena and Theodoropoulos, {George E} and Stefania Moz and Gabriele Capurso and Oliver Strobel and Silvia Carrara and Thilo Hackert and Viktor Hlavac and Livia Archibugi and Martin Oliverius and Giuseppe Vanella and Pavel Vodicka and Arcidiacono, {Paolo Giorgio} and Raffaele Pezzilli and Milanetto, {Anna Caterina} and Lawlor, {Rita T} and Audrius Ivanauskas and Andrea Szentesi and Juozas Kupcinskas and Testoni, {Sabrina G G} and Martin Lovecek and Michael Nentwich and Maria Gazouli and Claudio Luchini and Zuppardo, {Raffaella Alessia} and Erika Darvasi and Hermann Brenner and Cristian Gheorghe and Krzysztof Jamroziak and Federico Canzian and Daniele Campa",
note = "{\textcopyright} 2021 UICC.",
year = "2021",
month = jun,
day = "1",
doi = "10.1002/ijc.33475",
language = "English",
volume = "148",
pages = "2779--2788",
journal = "INT J CANCER",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

AU - Corradi, Chiara

AU - Gentiluomo, Manuel

AU - Gajdán, László

AU - Cavestro, Giulia Martina

AU - Kreivenaite, Edita

AU - Di Franco, Gregorio

AU - Sperti, Cosimo

AU - Giaccherini, Matteo

AU - Petrone, Maria Chiara

AU - Tavano, Francesca

AU - Gioffreda, Domenica

AU - Morelli, Luca

AU - Soucek, Pavel

AU - Andriulli, Angelo

AU - Izbicki, Jakob R

AU - Napoli, Niccolò

AU - Małecka-Panas, Ewa

AU - Hegyi, Péter

AU - Neoptolemos, John P

AU - Landi, Stefano

AU - Vashist, Yogesh

AU - Pasquali, Claudio

AU - Lu, Ye

AU - Cervena, Klara

AU - Theodoropoulos, George E

AU - Moz, Stefania

AU - Capurso, Gabriele

AU - Strobel, Oliver

AU - Carrara, Silvia

AU - Hackert, Thilo

AU - Hlavac, Viktor

AU - Archibugi, Livia

AU - Oliverius, Martin

AU - Vanella, Giuseppe

AU - Vodicka, Pavel

AU - Arcidiacono, Paolo Giorgio

AU - Pezzilli, Raffaele

AU - Milanetto, Anna Caterina

AU - Lawlor, Rita T

AU - Ivanauskas, Audrius

AU - Szentesi, Andrea

AU - Kupcinskas, Juozas

AU - Testoni, Sabrina G G

AU - Lovecek, Martin

AU - Nentwich, Michael

AU - Gazouli, Maria

AU - Luchini, Claudio

AU - Zuppardo, Raffaella Alessia

AU - Darvasi, Erika

AU - Brenner, Hermann

AU - Gheorghe, Cristian

AU - Jamroziak, Krzysztof

AU - Canzian, Federico

AU - Campa, Daniele

N1 - © 2021 UICC.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 × 10-9 ). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.

AB - Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 × 10-9 ). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.

U2 - 10.1002/ijc.33475

DO - 10.1002/ijc.33475

M3 - SCORING: Journal article

C2 - 33534179

VL - 148

SP - 2779

EP - 2788

JO - INT J CANCER

JF - INT J CANCER

SN - 0020-7136

IS - 11

ER -