Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation.
Standard
Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation. / Börno, Stefan T; Fischer, Axel; Kerick, Martin; Fälth, Maria; Laible, Mark; Brase, Jan C; Kuner, Ruprecht; Dahl, Andreas; Grimm, Christina; Sayanjali, Behnam; Isau, Melanie; Röhr, Christina; Wunderlich, Andrea; Timmermann, Bernd; Claus, Rainer; Plass, Christoph; Graefen, Markus; Simon, Ronald; Demichelis, Francesca; Rubin, Mark A; Sauter, Guido; Schlomm, Thorsten; Sültmann, Holger; Lehrach, Hans; Schweiger, Michal R.
in: CANCER DISCOV, Jahrgang 2, Nr. 11, 11, 2012, S. 1024-1035.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Genome-wide DNA methylation events in TMPRSS2-ERG fusion-negative prostate cancers implicate an EZH2-dependent mechanism with miR-26a hypermethylation.
AU - Börno, Stefan T
AU - Fischer, Axel
AU - Kerick, Martin
AU - Fälth, Maria
AU - Laible, Mark
AU - Brase, Jan C
AU - Kuner, Ruprecht
AU - Dahl, Andreas
AU - Grimm, Christina
AU - Sayanjali, Behnam
AU - Isau, Melanie
AU - Röhr, Christina
AU - Wunderlich, Andrea
AU - Timmermann, Bernd
AU - Claus, Rainer
AU - Plass, Christoph
AU - Graefen, Markus
AU - Simon, Ronald
AU - Demichelis, Francesca
AU - Rubin, Mark A
AU - Sauter, Guido
AU - Schlomm, Thorsten
AU - Sültmann, Holger
AU - Lehrach, Hans
AU - Schweiger, Michal R
PY - 2012
Y1 - 2012
N2 - Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high-throughput sequencing study investigating genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using methylated DNA immunoprecipitation sequencing. Comparative analyses identified more than 147,000 cancer-associated epigenetic alterations. In addition, global methylation patterns show significant differences based on the TMPRSS2-ERG rearrangement status. We propose the hypermethylation of miR-26a as an alternative pathway of ERG rearrangement-independent EZH2 activation. The observed increase in differential methylation events in fusion-negative tumors can explain the tumorigenic process in the absence of genomic rearrangements.
AB - Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high-throughput sequencing study investigating genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using methylated DNA immunoprecipitation sequencing. Comparative analyses identified more than 147,000 cancer-associated epigenetic alterations. In addition, global methylation patterns show significant differences based on the TMPRSS2-ERG rearrangement status. We propose the hypermethylation of miR-26a as an alternative pathway of ERG rearrangement-independent EZH2 activation. The observed increase in differential methylation events in fusion-negative tumors can explain the tumorigenic process in the absence of genomic rearrangements.
KW - Humans
KW - Male
KW - Gene Fusion
KW - Transfection
KW - DNA Methylation
KW - Oncogene Proteins, Fusion/genetics
KW - Epigenomics
KW - Genome, Human
KW - MicroRNAs/genetics
KW - Polycomb Repressive Complex 2/genetics
KW - Prostatic Neoplasms/genetics/pathology
KW - Humans
KW - Male
KW - Gene Fusion
KW - Transfection
KW - DNA Methylation
KW - Oncogene Proteins, Fusion/genetics
KW - Epigenomics
KW - Genome, Human
KW - MicroRNAs/genetics
KW - Polycomb Repressive Complex 2/genetics
KW - Prostatic Neoplasms/genetics/pathology
M3 - SCORING: Journal article
VL - 2
SP - 1024
EP - 1035
JO - CANCER DISCOV
JF - CANCER DISCOV
SN - 2159-8274
IS - 11
M1 - 11
ER -