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Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia

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Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia. / Bansal, V; Mitjans, M; Burik, C A P; Linnér, R K; Okbay, A; Rietveld, C A; Begemann, M; Bonn, S; Ripke, S; de Vlaming, R; Nivard, M G; Ehrenreich, H; Koellinger, P D.

in: NAT COMMUN, Jahrgang 9, Nr. 1, 06.08.2018, S. 3078.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bansal, V, Mitjans, M, Burik, CAP, Linnér, RK, Okbay, A, Rietveld, CA, Begemann, M, Bonn, S, Ripke, S, de Vlaming, R, Nivard, MG, Ehrenreich, H & Koellinger, PD 2018, 'Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia', NAT COMMUN, Jg. 9, Nr. 1, S. 3078. https://doi.org/10.1038/s41467-018-05510-z

APA

Bansal, V., Mitjans, M., Burik, C. A. P., Linnér, R. K., Okbay, A., Rietveld, C. A., Begemann, M., Bonn, S., Ripke, S., de Vlaming, R., Nivard, M. G., Ehrenreich, H., & Koellinger, P. D. (2018). Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia. NAT COMMUN, 9(1), 3078. https://doi.org/10.1038/s41467-018-05510-z

Vancouver

Bansal V, Mitjans M, Burik CAP, Linnér RK, Okbay A, Rietveld CA et al. Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia. NAT COMMUN. 2018 Aug 6;9(1):3078. https://doi.org/10.1038/s41467-018-05510-z

Bibtex

@article{0a37d429e9e4402aacc25082f7f8c99e,
title = "Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia",
abstract = "Higher educational attainment (EA) is negatively associated with schizophrenia (SZ). However, recent studies found a positive genetic correlation between EA and SZ. We investigate possible causes of this counterintuitive finding using genome-wide association study results for EA and SZ (N = 443,581) and a replication cohort (1169 controls; 1067 cases) with deeply phenotyped SZ patients. We find strong genetic dependence between EA and SZ that cannot be explained by chance, linkage disequilibrium, or assortative mating. Instead, several genes seem to have pleiotropic effects on EA and SZ, but without a clear pattern of sign concordance. Using EA as a proxy phenotype, we isolate FOXO6 and SLITRK1 as novel candidate genes for SZ. Our results reveal that current SZ diagnoses aggregate over at least two disease subtypes: one part resembles high intelligence and bipolar disorder (BIP), while the other part is a cognitive disorder that is independent of BIP.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.",
author = "V Bansal and M Mitjans and Burik, {C A P} and Linn{\'e}r, {R K} and A Okbay and Rietveld, {C A} and M Begemann and S Bonn and S Ripke and {de Vlaming}, R and Nivard, {M G} and H Ehrenreich and Koellinger, {P D}",
year = "2018",
month = aug,
day = "6",
doi = "10.1038/s41467-018-05510-z",
language = "English",
volume = "9",
pages = "3078",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia

AU - Bansal, V

AU - Mitjans, M

AU - Burik, C A P

AU - Linnér, R K

AU - Okbay, A

AU - Rietveld, C A

AU - Begemann, M

AU - Bonn, S

AU - Ripke, S

AU - de Vlaming, R

AU - Nivard, M G

AU - Ehrenreich, H

AU - Koellinger, P D

PY - 2018/8/6

Y1 - 2018/8/6

N2 - Higher educational attainment (EA) is negatively associated with schizophrenia (SZ). However, recent studies found a positive genetic correlation between EA and SZ. We investigate possible causes of this counterintuitive finding using genome-wide association study results for EA and SZ (N = 443,581) and a replication cohort (1169 controls; 1067 cases) with deeply phenotyped SZ patients. We find strong genetic dependence between EA and SZ that cannot be explained by chance, linkage disequilibrium, or assortative mating. Instead, several genes seem to have pleiotropic effects on EA and SZ, but without a clear pattern of sign concordance. Using EA as a proxy phenotype, we isolate FOXO6 and SLITRK1 as novel candidate genes for SZ. Our results reveal that current SZ diagnoses aggregate over at least two disease subtypes: one part resembles high intelligence and bipolar disorder (BIP), while the other part is a cognitive disorder that is independent of BIP.

AB - Higher educational attainment (EA) is negatively associated with schizophrenia (SZ). However, recent studies found a positive genetic correlation between EA and SZ. We investigate possible causes of this counterintuitive finding using genome-wide association study results for EA and SZ (N = 443,581) and a replication cohort (1169 controls; 1067 cases) with deeply phenotyped SZ patients. We find strong genetic dependence between EA and SZ that cannot be explained by chance, linkage disequilibrium, or assortative mating. Instead, several genes seem to have pleiotropic effects on EA and SZ, but without a clear pattern of sign concordance. Using EA as a proxy phenotype, we isolate FOXO6 and SLITRK1 as novel candidate genes for SZ. Our results reveal that current SZ diagnoses aggregate over at least two disease subtypes: one part resembles high intelligence and bipolar disorder (BIP), while the other part is a cognitive disorder that is independent of BIP.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, Non-P.H.S.

U2 - 10.1038/s41467-018-05510-z

DO - 10.1038/s41467-018-05510-z

M3 - SCORING: Journal article

C2 - 30082721

VL - 9

SP - 3078

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -